Results 61 to 70 of about 15,454 (234)

Spheroid culture to select theoretical therapeutic drugs in intravascular large B‐cell lymphoma

Cancer Science, Volume 116, Issue 1, Page 214-225, January 2025.
Abstract Intravascular large B‐cell lymphoma (IVLBCL) is a rare type of extranodal large B‐cell lymphoma that is characterized by the proliferation of lymphoma cells in the lumina of small vessels. Recent progress uncovering the genetic characteristics associated with MYD88/CD79B mutations has stimulated interest in the use of drugs targeting B‐cell ...
Mika Takai, Kazuyuki Shimada, Katsuya Furukawa, Yusuke Yamaga, Soichi Yoshiyama, Yusuke Kagaya, Takashi Suzuki, Kazuhiko Hayashi, Satoko Shimada, Kennosuke Karube, Hitoshi Kiyoi   +10 more
wiley   +1 more source

Issue Information

, 2023
Clinical and Translational Science, Volume 16, Issue 7, Page 1097-1100, July 2023.
wiley   +1 more source

Nanostructural Modulation of G‐Quadruplex DNA in Neurodegeneration: Orotate Interaction Revealed Through Experimental and Computational Approaches

Journal of Neurochemistry, Volume 169, Issue 1, January 2025.
Aim of this study is to investigate drugs that modulate GGGGCC repeat aggregation, a key feature in neurodegenerative diseases such as ALS and FTD. The research emphasizes the role of the C9orf72 gene, which is implicated in these disorders, and focuses on G‐quadruplex (G4) DNA structures formed by these repeats.
Andrea Patrizia Falanga, Ilaria Piccialli, Francesca Greco, Stefano D'Errico, Maria Grazia Nolli, Nicola Borbone, Giorgia Oliviero, Giovanni N. Roviello   +7 more
wiley   +1 more source

Labeling of Unique Sequences in Double-Stranded DNA at Sites of Vicinal Nicks Generated by Nicking Endonucleases [PDF]

, 2008
We describe a new approach for labeling of unique sequences within dsDNA under nondenaturing conditions. The method is based on the site-specific formation of vicinal nicks, which are created by nicking endonucleases (NEases) at specified DNA sites on ...
Frank-Kamenetskii, Maxim D., Kuhn, Heiko
core   +3 more sources

Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides

Nucleic Acids Research, 1988
The Rp- and Sp-diastereomers of the phosphorothioate-containing oligonucleotide d[ApAp(S)ApA] have been synthesized. They and the tetramer d[ApApApA] were tested as substrates for staphylococcal nuclease, DNase II and spleen phosphodiesterase. For digestions with DNase I these oligonucleotides were converted to the 5'-phosphorylated derivates.
Fritz Eckstein, Stephan Spitzer
openaire   +4 more sources

Oligonucleotide‐Based Photoaffinity Probes: Chemical Tools and Applications for Protein Labeling

ChemBioChem, Volume 25, Issue 19, October 1, 2024.
Photoactivatable oligonucleotides in combination with recent developments in mass spectrometry are powerful tools for studying nucleic acid‐protein interactions involved in numerous biological processes. In this review, we provide a comprehensive overview of the different strategies for incorporating the most used photoreactive reagents into ...
Carole Saintomé, Océane Monfret, Gilles Doisneau, Dominique Guianvarc'h   +3 more
wiley   +1 more source

CRKL but not CRKII contributes to hemin‐induced erythroid differentiation of CML

Journal of Cellular and Molecular Medicine, Volume 28, Issue 9, May 2024.
Abstract Destruction of erythropoiesis process leads to various diseases, including thrombocytopenia, anaemia, and leukaemia. miR‐429‐CT10 regulation of kinase‐like (CRKL) axis involved in development, progression and metastasis of cancers. However, the exact role of miR‐429‐CRKL axis in leukaemic cell differentiation are still unknown.
Chunmei Guo, Xinxin Lv, Qiuling Zhang, Lina Yi, Yingying Ren, Zhaopeng Li, Jinsong Yan, Shanliang Zheng, Ming‐Zhong Sun, Shuqing Liu   +9 more
wiley   +1 more source

Reactive oxygen species are signaling molecules that modulate plant reproduction

Plant, Cell &Environment, Volume 47, Issue 5, Page 1592-1605, May 2024.
Abstract Reactive oxygen species (ROS) can serve as signaling molecules that are essential for plant growth and development but abiotic stress can lead to ROS increases to supraoptimal levels resulting in cellular damage. To ensure efficient ROS signaling, cells have machinery to locally synthesize ROS to initiate cellular responses and to scavenge ROS
Mohammad Foteh Ali, Gloria K. Muday
wiley   +1 more source

Analysis of efficiency of purification of HEX-oligonucleotides obtained by modified deblocking

Тонкие химические технологии, 2012
A new way of deblocking of synthetic hexachlorofluorescein-oligodeoxyribonucleotides (HEX-ODN) prevents the modification of the label and the accumulation of difficult to separated by-product.
A. G. Mosina, A. N. Chuvilin, I. P. Smirnov, V. F. Travkin, G. E. Pozmogova   +4 more
doaj  

Antiviral activity of modified oligonucleotides in human lymphoid cells infected with a strain of HIV‐1

Юг России: экология, развитие
Aim. To investigate the cell entry and antiretroviral properties of modified oligodeoxyribonucleotides targeting highly conserved regions of the HIV‐1 genome: the study was conducted using modified oligonucleotides containing phosphorothioate ...
L. G. Gotfrid, A. S. Pavlova, M. S. Kupryushkin, I. A. Pyshnaya, N. M. Gashnikova   +4 more
doaj   +1 more source