Results 161 to 170 of about 15,131 (222)

Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
This review examines the structural and enzymatic properties of cyclic GMP‐AMP synthase, including substrate promiscuity, homologs, and engineered variants. In addition, it evaluates potential expression systems for large‐scale enzyme production and analyzes reaction and purification strategies for the synthesis of cyclic dinucleotides to connect ...
Makram Fataeri, Katrin Rosenthal
wiley   +1 more source

An antibody uniquely binding short 2'-O-methyl RNA oligonucleotide duplexes: formation and recognition of target duplexes on cell surfaces. [PDF]

Front Immunol
Dunn IS, Lawler MM, Fagundes L, Simoes Junior M, Mangold A, Rinaldi D, Rose LB, Kurnick JT.   +7 more
europepmc   +1 more source

Self-Assembly of Heterochiral and Homochiral Peptides Conjugated to PNA Dimers and Their Integration in Peptide-Based Hydrogels. [PDF]

Chemistry
Miglioli I, Ajò A, Ciolo SD, Carofiglio M, Prisco DD, Siliqi D, De Cola L, Romanelli A.   +7 more
europepmc   +1 more source

Phase Separation of Nucleic Acids: Mechanisms, Properties, and Applications

Angewandte Chemie International Edition, Volume 65, Issue 11, 9 March 2026.
Recent discoveries have shown that single‐stranded long‐chain nucleic acids can undergo temperature‐induced phase separation, enabling formation of micrometer‐sized condensates. This Minireview discusses the current mechanistic understanding of this phenomenon, highlights strategies for controlling the physical and chemical properties of these ...
Weixiang Chen, Johann Fritzen, Andreas Walther   +2 more
wiley   +1 more source

Aminoglycoside-Peptide Nucleic Acid (PNA) Conjugates against Gram-Negative Bacteria. [PDF]

Bioconjug Chem
Siekierska I, Trylska J.
europepmc   +1 more source

A Michaelis‐Arbuzov‐Type Pathway to a Protected 2ʹ‐Deoxy‐2ʹ‐Selenomethyl‐Adenosine‐3ʹ,5ʹ‐Phosphoroselenolate Guanosine Dinucleotide for Use in Modified m7G Cap Synthesis

Chemistry – A European Journal, Volume 32, Issue 10, 9 March 2026.
Here we report a synthesis of the dinucleotide 4 for a projected future total synthesis of the m7G cap 1. Highlights of the route include: 1) a 3ʹ‐H‐phosphonate/5ʹ‐selenocyanate Michaelis‐Arbuzov coupling to forge the 3ʹ,5ʹ‐phosphoroselenolate; 2) an Amosova reductive selenomethylation to install the 2ʹ‐SeMe; 3) a solid CPR II 5ʹ‐O‐phosphitylation; and
K. Lawrence E. Hale, Helen O. McCarthy, Mark G. McLaughlin   +2 more
wiley   +1 more source

Targeting β-catenin: PROTACs and precision degraders for Wnt-driven cancers. [PDF]

Front Oncol
Trapani J, Caroland KP, Ahmed Y, Robbins DJ, Weiss VL, Lee E.   +5 more
europepmc   +1 more source

Biophysical and biological properties of splice-switching oligonucleotides and click conjugates containing LNA-phosphothiotriester linkages. [PDF]

Nucleic Acids Res
Dhara D, Hill AC, Ramesh A, Traore D, Radzikowska-Cieciura E, Wood MJA, Brown T.   +6 more
europepmc   +1 more source

New Transferrin Receptor-Targeting Conjugate Effectively Delivers DNA to Mouse Brain. [PDF]

Angew Chem Int Ed Engl
Song MS, Bustos AH, Bastue L, Mikutavicius J, Swiderski P, Clemens KJ, Habib N, Rossi J, Astakhova K.   +8 more
europepmc   +1 more source

Synthesis of Versatile DNA-Conjugated Aldehydes by Controlled Oxidation of Amines. [PDF]

Angew Chem Int Ed Engl
Zhao G, Zhu M, He P, Nie Q, Li Y, Zhang G, Li Y.   +6 more
europepmc   +1 more source