Results 181 to 190 of about 15,131 (222)

Synthesis of Oligonucleotide-Peptide PEG-Conjugated: The EGG (Oligonucleotide)-Chicken (Peptide) Dilemma?

Nucleosides, Nucleotides and Nucleic Acids, 2003
The synthesis of a peptide-PEG-oligonucleotide chimera is compared when starting from the peptide or from the oligonucleotide sequence.
BONORA, GIAN MARIA, BALLICO M., CAMPANER, PIETRO, DRIOLI S., ADAMO I.   +4 more
openaire   +3 more sources

Synthesis of Oligonucleotide—Peptide and Oligonucleotide—Protein Conjugates

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +2 more sources

Synthesis of oligonucleotide-peptide conjugates containing a KDEL signal sequence

Tetrahedron Letters, 1993
Abstract An improved method of preparation of oligonucleotide-peptide conjugates is described. An oligopeptide containing α and e-aminogroups is mainly substituted at its α-NH 2 end by e-maleimidocaproic acid- N -hydroxysuccinimide ester at pH 6.5 for 1 h. The N α -maleimidocaproyl-peptide derivative, purified by HPLC, reacts with the thiol group of
Khalil Arar, Michel Monsigny, Roger Mayer   +2 more
openaire   +1 more source

Native chemical ligation in the synthesis of internally modified oligonucleotide–peptide conjugates

Peptide Science, 2010
AbstractPeptide–oligonucleotide conjugates have frequently been synthesized to improve cellular delivery of antisense or antigene compounds, to allow the immobilization of peptide and protein conjugates on DNA arrays, or to decorate nucleic acid architectures with peptide functions. In such applications, the site of conjugation is of little importance,
Franziska, Diezmann, Hendrik, Eberhard, Oliver, Seitz   +2 more
openaire   +2 more sources

Synthesis of Oligonucleotide—Peptide Conjugates and Nucleopeptides

ChemInform, 2001
AbstractFor Abstract see ChemInform Abstract in Full Text.
openaire   +1 more source

ChemInform Abstract: Synthesis of Oligonucleotide‐Peptide Conjugates for Biomedical and Technological Applications

ChemInform, 2013
AbstractReview: 19 refs.
Anna Avino, Santiago Grijalvo, Sonia Perez‐Rentero, Alejandra Garibotti, Montserrat Terrazas, Ramon Eritja   +5 more
openaire   +1 more source

Synthesis of Oligonucleotide‐Peptide PEG‐Conjugated: The EGG (Oligonucleotide)‐Chicken (Peptide) Dilemma?

ChemInform, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Gian Maria Bonora, Maurizio Ballico, Pietro Campaner, Sara Drioli, Ilaria Adamo   +4 more
openaire   +1 more source

Nucleobase-involved native chemical ligation: a novel reaction between an oxanine nucleobase and N-terminal cysteine for oligonucleotide–peptide conjugation

Chemical Communications, 2020
A novel nucleobase-involved native chemical ligation (NbCL) that allows a site–specific oligonucleotide–peptide conjugation via a new S–N acyl transfer reaction between an oxanine nucleobase and N-terminal cysteine.
Eui Kyoung Jang, Yohei Koike, Yuko Ide, Kunihiko Tajima, Kenji Kanaori, Seung Pil Pack   +5 more
openaire   +2 more sources

Cationic Oligonucleotide−Peptide Conjugates with Aggregating Properties Enter Efficiently into Cells while Maintaining Hybridization Properties and Enzymatic Recognition

Journal of the American Chemical Society, 2006
Oligonucleotide delivery is a crucial issue for therapeutical purposes and is often addressed by conjugation to short cationic peptides although with controversial results. To further examine this mechanism, a 15-mer anionic oligonucleotide was conjugated to a cationic peptide in order to obtain a diblock compound with an overall positive charge with ...
Fraley, A.W., Pons, B., Dalkara, D., Nullans, G., Behr, J.-P., Zuber, G.   +5 more
openaire   +3 more sources

Characterization of antisense oligonucleotide–peptide conjugates with negative ionization electrospray mass spectrometry and liquid chromatography–mass spectrometry

Journal of Pharmaceutical and Biomedical Analysis, 2003
Covalent post-synthesis or solid-phase conjugation of peptides to oligonucleotides has been reported as a possible method of delivering antisense oligonucleotides into cells. While synthesis strategies for preparing these conjugates have been widely addressed, few detailed reports on their structural characterization have been published.
Unni, Tengvall, Seppo, Auriola, Maxim, Antopolsky, Alex, Azhayev, Leo, Biegelman   +4 more
openaire   +2 more sources