Results 1 to 10 of about 22,079 (142)

Integrated bioinformatic and in vivo analysis confirms the cardioprotective role of OPA1 [PDF]

BMC Cardiovascular Disorders
Background OPA1 is an inner mitochondrial membrane protein that mediates diverse signaling processes. OPA1 is important for cardiac function and protects against cardiac insults such as ischemia/reperfusion injury.
Claire Fong-McMaster, Serena M. Pulente, Luke S. Kennedy, Tyler K.T. Smith, Stephanie Myers, Michel N. Kanaan, Charbel Y. Karam, Matthew Cope, Michelle M. Levesque, Ella McIlroy, Ilka Lorenzen-Schmidt, Craig J. Goergen, Morgan D. Fullerton, Miroslava Cuperlovic-Culf, Erin E. Mulvihill, Mary-Ellen Harper   +15 more
doaj   +2 more sources

Effects of Mitochondrial Dynamics in the Pathophysiology of Obesity

Frontiers in Bioscience-Landmark, 2022
Obesity has become an urgent and serious public health challenge with an overwhelming increase over the decades worldwide. The rate of obese children and adolescents has recently accelerated, especially in China.
Jinling Wang, Xiufu Lin, Ningning Zhao, Guanping Dong, Wei Wu, Ke Huang, Junfen Fu   +6 more
doaj   +1 more source

Adipose tissue-specific ablation of PGC-1β impairs thermogenesis in brown fat

Disease Models & Mechanisms, 2022
Impaired thermogenesis observed in mice with whole-body ablation of peroxisome proliferator-activated receptor-γ coactivator-1β (PGC-1β; officially known as PPARGC1B) may result from impaired brown fat (brown adipose tissue; BAT) function, but other ...
Jiří Funda, Josep A. Villena, Kristina Bardova, Katerina Adamcova, Illaria Irodenko, Pavel Flachs, Ivana Jedlickova, Eliska Haasova, Martin Rossmeisl, Jan Kopecky, Petra Janovska   +10 more
doaj   +1 more source

The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury

Nature Communications, 2023
Mitochondria are critical for metabolic homeostasis of the liver, and their dysfunction is a major cause of liver diseases. Optic atrophy 1 (OPA1) is a mitochondrial fusion protein with a role in cristae shaping.
Hakjoo Lee, Tae Jin Lee, Chad A. Galloway, Wenbo Zhi, Wei Xiao, Karen L. de Mesy Bentley, Ashok Sharma, Yong Teng, Hiromi Sesaki, Yisang Yoon   +9 more
doaj   +1 more source

OPA1-Exon4b modulates the migration and invasion of hepatocellular carcinoma cells by ATP regulation

Mitochondrial Communications, 2023
Optic Atrophy 1 (OPA1), a mitochondrial inner protein, is involved in both mitochondrial fusion dynamic and cell apoptosis. OPA1 Exon4b (OPA1-Exon4b) was reported to be downregulated in hepatocellular carcinoma (HCC).
Haite Tang, Zhijuan Hu, Liang Yang, Zifeng Ruan, Hao Wang, Yunhao Zhou, Feixiang Bao, Xingguo Liu   +7 more
doaj   +1 more source

OPA1 Modulates Mitochondrial Ca2+ Uptake Through ER-Mitochondria Coupling

Frontiers in Cell and Developmental Biology, 2022
Autosomal Dominant Optic Atrophy (ADOA), a disease that causes blindness and other neurological disorders, is linked to OPA1 mutations. OPA1, dependent on its GTPase and GED domains, governs inner mitochondrial membrane (IMM) fusion and cristae ...
Benjamín Cartes-Saavedra, Benjamín Cartes-Saavedra, Josefa Macuada, Daniel Lagos, Duxan Arancibia, María E. Andrés, Patrick Yu-Wai-Man, Patrick Yu-Wai-Man, Patrick Yu-Wai-Man, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner   +11 more
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Opa1 Prevents Apoptosis and Cisplatin-Induced Ototoxicity in Murine Cochleae

Frontiers in Cell and Developmental Biology, 2021
Optic atrophy1 (OPA1) is crucial for inner mitochondrial membrane (IMM) fusion and essential for maintaining crista structure and mitochondrial morphology.
Tingting Dong, Xuejie Zhang, Yiqing Liu, Shan Xu, Haishuang Chang, Fengqiu Chen, Lulu Pan, Shaoru Hu, Min Wang, Min Lu   +9 more
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Mitochondrial Fusion Via OPA1 and MFN1 Supports Liver Tumor Cell Metabolism and Growth

Cells, 2020
Metabolic reprogramming universally occurs in cancer. Mitochondria act as the hubs of bioenergetics and metabolism. The morphodynamics of mitochondria, comprised of fusion and fission processes, are closely associated with mitochondrial functions and are
Meng Li, Ling Wang, Yijin Wang, Shaoshi Zhang, Guoying Zhou, Ruby Lieshout, Buyun Ma, Jiaye Liu, Changbo Qu, Monique M. A. Verstegen, Dave Sprengers, Jaap Kwekkeboom, Luc J. W. van der Laan, Wanlu Cao, Maikel P. Peppelenbosch, Qiuwei Pan   +15 more
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Berberine mitigates hepatic insulin resistance by enhancing mitochondrial architecture via the SIRT1/Opa1 signalling pathway

Acta Biochimica et Biophysica Sinica, 2022
The aberrant changes of fussion/fission-related proteins can trigger mitochondrial dynamics imbalance, which cause mitochondrial dysfunctions and result insulin resistance (IR).
Xu Jia, Zhang Yining, Yu Zhiyi, Guan Yueqi, Lv Yuqian, Zhang Meishuang, Zhang Ming, Chen Li, Lv Xiaoyan, Guan Fengying   +9 more
doaj   +1 more source

CRISPR-Cas9 correction of OPA1 c.1334G>A: p.R445H restores mitochondrial homeostasis in dominant optic atrophy patient-derived iPSCs

Molecular Therapy: Nucleic Acids, 2021
Autosomal dominant optic atrophy (DOA) is the most common inherited optic neuropathy in the United Kingdom. DOA has an insidious onset in early childhood, typically presenting with bilateral, central visual loss caused by the preferential loss of retinal
Paul E. Sladen, Pedro R.L. Perdigão, Grace Salsbury, Tatiana Novoselova, Jacqueline van der Spuy, J. Paul Chapple, Patrick Yu-Wai-Man, Michael E. Cheetham   +7 more
doaj   +1 more source