Results 11 to 20 of about 22,170 (231)

Mitochondrial Membrane Dynamics—Functional Positioning of OPA1 [PDF]

Antioxidants, 2018
The maintenance of mitochondrial energetics requires the proper regulation of mitochondrial morphology, and vice versa. Mitochondrial dynamins control mitochondrial morphology by mediating fission and fusion.
Hakjoo Lee, Yisang Yoon
doaj   +3 more sources

OPA1 in Cardiovascular Health and Disease [PDF]

Current Drug Targets, 2015
Mitochondria are known to play crucial roles in normal cellular physiology and in more recent years they have been implicated in a wide range of pathologies. Central to both these roles is their ability to alter their shape interchangeably between two different morphologies: an elongated interconnected network and a fragmented discrete phenotype ...
Niall, Burke, Andrew R, Hall, Derek J, Hausenloy   +2 more
openaire   +4 more sources

Extramitochondrial OPA1 and adrenocortical function [PDF]

Molecular and Cellular Endocrinology, 2013
We have previously described that silencing of the mitochondrial protein OPA1 enhances mitochondrial Ca(2+) signaling and aldosterone production in H295R adrenocortical cells. Since extramitochondrial OPA1 (emOPA1) was reported to facilitate cAMP-induced lipolysis, we hypothesized that emOPA1, via the enhanced hydrolysis of cholesterol esters, augments
Fülöp, László, Rajki, Anikó, Katona, Dávid, Szanda, Gergö, Spät, András   +4 more
openaire   +3 more sources

OPA1 in Lipid Metabolism: Function of OPA1 in Lipolysis and Thermogenesis of Adipocytes [PDF]

Hormone and Metabolic Research, 2017
AbstractOPA1 (Optic Atrophy 1) is a mitochondrial GTPase known to regulate fission of mitochondria. It was recently also shown to locate on lipid droplets in adipocytes where it functions as an A-kinase anchoring protein (AKAP) that mediates adrenergic control of lipolysis by facilitating PKA phosphorylation of perilipin (Plin1).
Chu, Dinh Toi, Tao, Yang, Tasken, Kjetil
openaire   +4 more sources

OPA1 and Angiogenesis: Beyond the Fusion Function [PDF]

Cell Metabolism, 2020
In this issue of Cell Metabolism, Herkenne et al. (2020) show that the mitochondrial fusion protein OPA1 promotes angiogenesis independent of its function in mitochondrial dynamics, identifying a key new therapeutic target to prevent vascular growth during development and tumor formation.
Max-Hinderk, Schuler, Adam L, Hughes
openaire   +2 more sources

Mitochondrial OPA1, apoptosis, and heart failure [PDF]

Cardiovascular Research, 2009
Mitochondrial fusion and fission are essential processes for preservation of normal mitochondrial function. We hypothesized that fusion proteins would be decreased in heart failure (HF), as the mitochondria in HF have been reported to be small and dysfunctional.Expression of optic atrophy 1 (OPA1), a mitochondrial fusion protein, was decreased in both ...
Le, Chen, Qizhi, Gong, James P, Stice, Anne A, Knowlton   +3 more
openaire   +2 more sources

OPA1, a molecular regulator of dilated cardiomyopathy

Journal of Cellular and Molecular Medicine, 2023
AbstractDilated cardiomyopathy (DCM) is a disease with no specific treatment, poor prognosis and high mortality. During DCM development, there is apoptosis, mitochondrial dynamics imbalance and changes in cristae structure. Optic atrophy 1 (OPA1) appears at high frequency in these three aspects.
Jiaqi Chen, Jianan Shao, Yaoyao Wang, Kangxiang Wu, Mingyuan Huang   +4 more
openaire   +2 more sources

‘Behr syndrome’ with OPA1 compound heterozygote mutations [PDF]

Brain, 2014
Sir, We have been following with great interest the developments in the field of phenotypic diversity associated with mutations in the OPA1 gene, having contributed to describe the DOA ‘ plus ’ phenotype in a joint effort with other groups (Amati-Bonneau et al. , 2008; Hudson et al. , 2008; Yu-Wai-Mann et al. , 2010).
CARELLI, VALERIO, Sabatelli, Mario, Carrozzo, Rosalba, Rizza, Teresa, Schimpf, Simone, Wissinger, Bernd, ZANNA, CLAUDIA, RUGOLO, MICHELA, LA MORGIA, CHIARA, Caporali, Leonardo, Carbonelli, Michele, Barboni, Piero, TONON, CATERINA, LODI, RAFFAELE, Bertini, Enrico   +14 more
openaire   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Sensorineural hearing loss in OPA1-linked disorders [PDF]

Brain, 2013
ARTICLE Sir, We have read with interest the article by Yu-Wai-Man et al. (2010) reporting heterogeneous multi-system manifestations in 104 patients affected with autosomal dominant optic atrophy (DOA) caused by mutations in the nuclear gene encoding the mitochondrial OPA1 protein. Yu-Wai-Man et al.
Leruez, Stéphanie, Milea, Dan, Defoort-Dhellemmes, Sabine, Colin, Estelle, Crochet, M., Procaccio, Vincent, Ferré, Marc, Lamblin, J., Drouin-Garraud, V., Vincent-Delorme, Catherine, Lenaers, Guy, Hamel, Christian, Blanchet, Catherine, Juul, G., Larsen, M., Verny, Christophe, Reynier, Pascal, Amati-Bonneau, Patrizia, Bonneau, Dominique   +18 more
openaire   +4 more sources