Summary A 20‐year‐old Camargue pony mare was referred for acute‐onset neurological signs and intermittent colic. Clinical examination revealed obtundation, cranial nerve deficits, head pressing, ventral strabismus and ataxia. Laboratory analyses showed marked hyperammonaemia, hyperbilirubinemia, severe increases in liver enzymes, hypoalbuminaemia and ...
C. Maino +5 more
wiley +1 more source
Molecular and Biochemical Phenotypes Underlying Reactive Astrocytosis in Primary Optic Nerve Head Astrocytes [PDF]
Glaucoma is a progressive optic neuropathy that manifests in a pathological triad of optic nerve head remodeling, damage to optic nerve axons, and retinal ganglion cell death.
Ghosh, Anita Kirti
core +1 more source
Estrogen Protects Optic Nerve Head Astrocytes Against Oxidative Stress by Preventing Caspase-3 Activation, Tau Dephosphorylation at Ser<sup>422</sup> and the Formation of Tau Protein Aggregates. [PDF]
Means JC, Lopez AA, Koulen P.
europepmc +1 more source
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl +10 more
wiley +1 more source
Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi +2 more
wiley +1 more source
Isolation and characterization of human optic nerve head astrocytes and lamina cribrosa cells. [PDF]
Lopez NN, Clark AF, Tovar-Vidales T.
europepmc +1 more source
Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han +7 more
wiley +1 more source
Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden +1 more
wiley +1 more source
Histone Deacetylases Regulation by δ-Opioids in Human Optic Nerve Head Astrocytes. [PDF]
Zaidi SAH +6 more
europepmc +1 more source
➢Extracellular vesicles (EVs) mediate the coupling of angiogenesis and neurogenesis. ➢Ischemic cerebral endothelial cell (CEC) derived EVs enhance neurogenesis. ➢EVs derived from either non‐ischemic or ischemic neural stem cells (NSCs) promote in vitro angiogenesis. ➢EV‐transmitted miRNAs regulate stroke‐induced neurogenesis and angiogenesis.
Xianshuang Liu +8 more
wiley +1 more source

