Results 111 to 120 of about 1,824,086 (180)

Severe chronic neutrophilic cholangiohepatitis with massive choledocholithiasis and hepatolithiasis in a pony

open access: yesEquine Veterinary Education, Volume 38, Issue 12, Page e942-e950, December 2026.
Summary A 20‐year‐old Camargue pony mare was referred for acute‐onset neurological signs and intermittent colic. Clinical examination revealed obtundation, cranial nerve deficits, head pressing, ventral strabismus and ataxia. Laboratory analyses showed marked hyperammonaemia, hyperbilirubinemia, severe increases in liver enzymes, hypoalbuminaemia and ...
C. Maino   +5 more
wiley   +1 more source

Molecular and Biochemical Phenotypes Underlying Reactive Astrocytosis in Primary Optic Nerve Head Astrocytes [PDF]

open access: yes, 2019
Glaucoma is a progressive optic neuropathy that manifests in a pathological triad of optic nerve head remodeling, damage to optic nerve axons, and retinal ganglion cell death.
Ghosh, Anita Kirti
core   +1 more source

Neurotransmitter‐Defined Degeneration Patterns in Sporadic and C9orf72‐Associated Amyotrophic Lateral Sclerosis: Predilection to GABAergic, Serotonergic, Opioid, Glutamatergic, Endocannabinoid, and Microglial Systems—Implications for Therapy Development

open access: yesAnnals of Neurology, Volume 100, Issue 5, Page 948-961, November 2026.
Objective Amyotrophic lateral sclerosis (ALS) has a markedly distinctive clinical and neuroradiological signature, with the preferential involvement of specific brain networks and the apparent sparing of others. The molecular underpinnings of the strikingly selective anatomical vulnerability have not been fully elucidated to date despite the potential ...
Marlene Tahedl   +10 more
wiley   +1 more source

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

open access: yesAnalysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi   +2 more
wiley   +1 more source

Advances in Multidimensional Molecular Mechanisms of Epilepsy and Precision Therapy Strategies

open access: yesCNS Neuroscience &Therapeutics, Volume 32, Issue 11, November 2026.
Epilepsy arises from a multidimensional network imbalance, integrating genetic, inflammatory, and metabolic disruptions. This complexity drives neuronal hyperexcitability and underpins therapeutic challenges. Our review highlights how emerging precision strategies, from targeted molecular therapies to neuromodulation, offer a transformative path toward
Yimin Han   +7 more
wiley   +1 more source

Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA

open access: yesGlia, Volume 74, Issue 11, November 2026.
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden   +1 more
wiley   +1 more source

Histone Deacetylases Regulation by δ-Opioids in Human Optic Nerve Head Astrocytes. [PDF]

open access: yesInvest Ophthalmol Vis Sci, 2020
Zaidi SAH   +6 more
europepmc   +1 more source

Extracellular Vesicles Enhance The Coupling of Neurogenesis and Angiogenesis and Neurological Recovery By Transfer of Micrornas After Stroke

open access: yesJournal of Extracellular Biology, Volume 5, Issue 11, November 2026.
➢Extracellular vesicles (EVs) mediate the coupling of angiogenesis and neurogenesis. ➢Ischemic cerebral endothelial cell (CEC) derived EVs enhance neurogenesis. ➢EVs derived from either non‐ischemic or ischemic neural stem cells (NSCs) promote in vitro angiogenesis. ➢EV‐transmitted miRNAs regulate stroke‐induced neurogenesis and angiogenesis.
Xianshuang Liu   +8 more
wiley   +1 more source

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