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ORAI channels and cancer [PDF]
Cell Calcium, 2018 Cancer is a major cause of death. The diversity of cancer types and the propensity of cancers to acquire resistance to therapies, including new molecularly targeted and immune-based therapies, drives the search for new ways to understand cancer progression.
Gregory Monteith, Silke Chalmers
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Revista Pai Inácio de Literatura e Arte, 2021
Trabalho submetido à Revista Pai Inácio de Literatura e ...
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Trabalho submetido à Revista Pai Inácio de Literatura e ...
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The STIM-Orai Pathway: The Interactions Between STIM and Orai
2017A primary Ca2+ entry pathway in non-excitable cells is established by the Ca2+ release-activated Ca2+ channels. Their two limiting molecular components include the Ca2+-sensor protein STIM1 located in the endoplasmic reticulum and the Orai channel in the plasma membrane.
Marc, Fahrner +4 more
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2016
Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signalling pathway for a variety of cell functions, including T-cell activation as well as mast-cell degranulation. Depletion of [Ca(2+)]ER results in activation of Ca(2+) channels within the plasmamembrane that mediate sustained Ca(2+) influx which is ...
Irene, Frischauf +3 more
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Ca(2+) influx via store-operated Ca(2+) release activated Ca(2+) (CRAC) channels represents a main signalling pathway for a variety of cell functions, including T-cell activation as well as mast-cell degranulation. Depletion of [Ca(2+)]ER results in activation of Ca(2+) channels within the plasmamembrane that mediate sustained Ca(2+) influx which is ...
Irene, Frischauf +3 more
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The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
2017Considerable progress has been made elucidating the molecular mechanisms of calcium (Ca2+) sensing by stromal interaction molecules (STIMs) and the basis for Orai channel activity. This chapter focuses on the available high-resolution structural details of STIM and Orai proteins with respect to the regulation of store-operated Ca2+ entry (SOCE ...
Jinhui, Zhu +2 more
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The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
2017Cysteines are among the least abundant amino acids found in proteins. Due to their unique nucleophilic thiol group, they are able to undergo a broad range of chemical modifications besides their known role in disulfide formation, such as S-sulfenylation (-SOH), S-sulfinylation (-SO(2)H), S-sufonylation (-SO(3)H), S-glutathionylation (-SSG), and S ...
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STIM and Orai in platelet function
Cell Calcium, 2011Physiological platelet activation and thrombus formation are essential to stop bleeding in case of vascular injury, whereas inadequate triggering of the same process in diseased vessels can lead to fatal thromboembolism and tissue ischemia of vital organs.
David, Varga-Szabo +2 more
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The TRPCs–STIM1–Orai Interaction
2014Ca(2+) signaling entails receptor-stimulated Ca(2+) release from the ER stores that serves as a signal to activate Ca(2+) influx channels present at the plasma membrane, the store-operated Ca(2+) channels (SOCs). The two known SOCs are the Orai and TRPC channels.
Seok, Choi +7 more
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