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The STIM-Orai Pathway: STIM-Orai Structures: Isolated and in Complex
2017Considerable progress has been made elucidating the molecular mechanisms of calcium (Ca2+) sensing by stromal interaction molecules (STIMs) and the basis for Orai channel activity. This chapter focuses on the available high-resolution structural details of STIM and Orai proteins with respect to the regulation of store-operated Ca2+ entry (SOCE ...
Jinhui, Zhu +2 more
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The STIM-Orai Pathway: Regulation of STIM and Orai by Thiol Modifications
2017Cysteines are among the least abundant amino acids found in proteins. Due to their unique nucleophilic thiol group, they are able to undergo a broad range of chemical modifications besides their known role in disulfide formation, such as S-sulfenylation (-SOH), S-sulfinylation (-SO(2)H), S-sufonylation (-SO(3)H), S-glutathionylation (-SSG), and S ...
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STIM and Orai in platelet function
Cell Calcium, 2011Physiological platelet activation and thrombus formation are essential to stop bleeding in case of vascular injury, whereas inadequate triggering of the same process in diseased vessels can lead to fatal thromboembolism and tissue ischemia of vital organs.
David, Varga-Szabo +2 more
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The TRPCs–STIM1–Orai Interaction
2014Ca(2+) signaling entails receptor-stimulated Ca(2+) release from the ER stores that serves as a signal to activate Ca(2+) influx channels present at the plasma membrane, the store-operated Ca(2+) channels (SOCs). The two known SOCs are the Orai and TRPC channels.
Seok, Choi +7 more
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2016
Os probióticos são definidos como “microrganismos vivos que, quando administrados em quantidades adequadas, conferem benefícios à saúde do hospedeiro”. Neste sentido, o uso de probióticos tem sido recomendado pelos clínicos. Entre os diferentes locais do organismo que têm sido descritos como benéficos para a aplicação de probióticos está a cavidade ...
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Os probióticos são definidos como “microrganismos vivos que, quando administrados em quantidades adequadas, conferem benefícios à saúde do hospedeiro”. Neste sentido, o uso de probióticos tem sido recomendado pelos clínicos. Entre os diferentes locais do organismo que têm sido descritos como benéficos para a aplicação de probióticos está a cavidade ...
openaire +1 more source