Results 91 to 100 of about 16,588 (201)
Age at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years
Journal of Sleep Research, Volume 35, Issue 2, April 2026.ABSTRACT Patients with narcolepsy type 1 (NT1), type 2 (NT2), idiopathic hypersomnia (IH) usually suffer from symptoms for years, even decades, before being diagnosed. We aimed to assess age at onset, age at diagnosis and changes in the diagnostic delays of these patients from 1990 to 2020 in a single centre.
Zhongxing Zhang +4 more
wiley +1 more source
Journal of Sleep Research, Volume 35, Issue 2, April 2026.ABSTRACT The 2019 coronavirus (COVID‐19) pandemic and associated lockdowns significantly disrupted healthcare systems, including access to pharmacological treatments such as sleep medication. This study investigated the number of first‐time dispensed hypnotic drugs during the first COVID‐19 lockdown in the Netherlands, using data from the Dutch ...
Dana M. Dijkgraaf +5 more
wiley +1 more source
Inhibition of orexin-1/hypocretin-1 receptors inhibits yohimbine-induced reinstatement of ethanol and sucrose seeking in Long–Evans rats [PDF]
\ud RATIONALE:\ud \ud Previous studies have shown that orexin-1/hypocretin-1 receptors play a role in self-administration and cue-induced reinstatement of food, drug, and ethanol seeking.
Jemma K. Richards +6 more
core +2 more sources
Longitudinal association between sleep and Alzheimer's pathology
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract INTRODUCTION Since sleep disturbance is a modifiable risk factor for Alzheimer's disease (AD), we tested associations between sleep and AD pathology in cognitively unimpaired (CU) persons. METHODS We included 223 participants from the PREVENT‐AD cohort with self‐reported measures of sleep, objective actigraphy measures of sleep, and positron ...
Bery Mohammediyan +13 more
wiley +1 more source
The neuromodulatory fragility hypothesis of Alzheimer's disease pathogenesis
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Sporadic Alzheimer's disease (AD) is associated with numerous risk factors, yet its precise cause remains unclear. Here, we describe a novel framework for AD pathogenesis, whereby diverse risk factors converge on neuromodulatory subcortical systems to confer AD risk or resilience.
Alfie Wearn +4 more
wiley +1 more source
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Neuromodulatory subcortical systems (NSSs) are uniquely susceptible to dementia‐related pathology, leading to frequent molecular and behavioral impairments associated with altered function of these nuclei. Some of these systems display clear sex‐specific cytoarchitecture and signaling leading to distinct physiology and behavioral outputs in ...
Rosaria J. Rae +53 more
wiley +1 more source
Wake‐promoting neuromodulators in Alzheimer's disease: Implications for sleep and brain clearance
Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.Abstract Neuromodulatory subcortical systems (NSS) regulate arousal, cognition, and sleep–wake transitions through widespread influence on cortical and subcortical networks. Increasing evidence links dysfunction of these systems to the pathogenesis of Alzheimer's disease (AD). Degeneration and dysregulation of NSS occurs during the preclinical phase of
Taylor J. Pedersen +7 more
wiley +1 more source
Glymphatic System Dysfunction in Central Nervous System Diseases
CNS Neuroscience &Therapeutics, Volume 32, Issue 3, March 2026.Glymphatic Dysfunction in Neurological Disorders: The glymphatic system is a brain‐wide clearance system that removes neurotoxic waste via AQP4‐mediated CSF‐ISF exchange. Dysfunction through AQP4 mislocalization, BBB injury, and inflammation annihilates clearance and causes acute (stroke, TBI) and chronic disease.
Anwar Zahran +14 more
wiley +1 more source
Paired-pulse Inhibition and Disinhibition of the Dentate Gyrus Following Orexin Receptors Inactivation in the Basolateral Amygdala. [PDF]
Basic Clin Neurosci, 2021 Akbari E +2 more
europepmc +1 more source