Results 161 to 170 of about 16,588 (201)
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Orexins Activate Histaminergic Neurons via the Orexin 2 Receptor
Biochemical and Biophysical Research Communications, 2002Orexins (orexin A and B) are recently identified neuropeptides implicated in the regulation of vigilance states and energy homeostasis. We have shown here the physiological significance of histaminergic neurons in the orexin-induced arousal responses. Immunohistochemical and electron microscopic techniques revealed direct synaptic interaction between ...
Akihiro, Yamanaka +9 more
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European Journal of Pharmacology, 2011
Orexin receptor antagonists are being investigated as therapeutic agents for insomnia and addictive disorders. In this study the interactions between the orexin receptors (orexin 1 receptor and orexin 2 receptor), orexin peptides, and small molecule orexin antagonists were explored.
Da-Thao, Tran +8 more
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Orexin receptor antagonists are being investigated as therapeutic agents for insomnia and addictive disorders. In this study the interactions between the orexin receptors (orexin 1 receptor and orexin 2 receptor), orexin peptides, and small molecule orexin antagonists were explored.
Da-Thao, Tran +8 more
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Orexins and orexin receptors: implication in feeding behavior
Regulatory Peptides, 1999Orexin-A and -B are initially identified as endogenous ligands for an orphan G protein coupled receptor. Since the discovery of orexins, investigations of their functions have been guided by their distribution in the lateral hypothalamic area, which has been implicated in feeding behavior.
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Orexins/hypocretins and orexin receptors in apoptosis: a mini‐review
Acta Physiologica, 2010AbstractAn unexpected and fascinating aspect of the neuropeptides orexins has recently emerged when it was shown that orexins acting at orexin receptors OX1R or OX2R induce dramatic apoptosis resulting in massive reduction in cell growth in various cancer cell lines.
M, Laburthe, T, Voisin, A, El Firar
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Sleep, feeding, and neuropeptides: roles of orexins and orexin receptors
Current Opinion in Neurobiology, 2002Recent studies using molecular genetics in mice and dogs, as well as histopathological analyses of human disease, have come to the same conclusion: the human sleep disorder narcolepsy is caused by failure of signaling mediated by orexin (hypocretin) neuropeptides. These and other findings strongly suggest that the orexin system plays a critical role in
Michihiro, Mieda, Masashi, Yanagisawa
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Hippocampal orexin receptors: Localization and function
2022Orexin (hypocretin) is secreted from the perifornical/lateral hypothalamus and is well known for sleep regulation. Orexin has two, orexin A and B, transcripts and two receptors, type 1 and 2 (OX1R and OX2R), located in the plasma membrane of neurons in different brain areas, including the hippocampus involved in learning, memory, seizures, and epilepsy,
Mahmoud, Elahdadi Salmani +2 more
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[Orexins and orexin receptors].
Ceskoslovenska fysiologie, 1999The hypothalamus plays a central role in the integrated control of feeding and energy homeostasis. Two novel neuropeptides Orexin -A and -B were identified. Orexins activate two closely related G protein-coupled receptors and stimulate food consumption. They act also as mediators in the central feedback mechanism and regulates feeding behavior.
K, Kotaska, R, Průsa
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Role of Orexin-B/Orexin 2 receptor in myocardial protection
Clinical Science, 2019Abstract Emerging evidence attributes to orexins/hypocretins (ORs) a protective function in the regulation of cardiovascular responses, heart rate, and hypertension. However, little is known about any direct effect of orexins in the heart function.
Imperatore Roberta, Cristino Luigia
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Orexin Projections and Localization of Orexin Receptors
2006The past several years have provided important insights into the physiological significance of the central orexin system. An important component of these is an increased understanding of the unique neuroanatomy of the orexin/hypocretin system. The orexin peptides, orexin-A and orexin-B, are produced in a restricted region of the central nervous system,
Jacob N. Marcus, Joel K. Elmquist
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2005
“Reverse pharmacological” approaches, i.e., ligand identification using cell lines expressing orphan receptors, combined with genetic engineering techniques, have increased our understanding of novel signaling systems in the body (1). Orexin/hypocretin is the first example of the factors that were successfully applied using such approaches (2).
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“Reverse pharmacological” approaches, i.e., ligand identification using cell lines expressing orphan receptors, combined with genetic engineering techniques, have increased our understanding of novel signaling systems in the body (1). Orexin/hypocretin is the first example of the factors that were successfully applied using such approaches (2).
openaire +1 more source