Results 41 to 50 of about 6,131 (232)

Neuroprotective Effects of Physical Activity: Evidence from Human and Animal Studies

Frontiers in Neurology, 2017
In the present article, we provide a review of current knowledge regarding the role played by physical activity (PA) in preventing age-related cognitive decline and reducing risk of dementia.
Sergio Chieffi, Giovanni Messina, Giovanni Messina, Ines Villano, Antonietta Messina, Anna Valenzano, Fiorenzo Moscatelli, Monica Salerno, Alessio Sullo, Roberto Avola, Vincenzo Monda, Giuseppe Cibelli, Marcellino Monda   +12 more
doaj   +1 more source

Effects of orexins on 17β-estradiol synthesis and P450 aromatase modulation in the testis of alpaca (Vicugna pacos). [PDF]

, 2018
The steroidogenic enzyme P450 aromatase (ARO) has a key role in the conversion of testosterone (T) into estrogens (E), expressed as 17β-estradiol. The presence and localization of this key enzyme have not been described before in the South American ...
Assisi L, Costagliola A, Liguori G, Mirabella N., Pelagalli A, Squillacioti C   +5 more
core   +1 more source

Cellular Mechanisms for Antinociception Produced by Oxytocin and Orexins in the Rat Spinal Lamina II—Comparison with Those of Other Endogenous Pain Modulators

Pharmaceuticals, 2019
Much evidence indicates that hypothalamus-derived neuropeptides, oxytocin, orexins A and B, inhibit nociceptive transmission in the rat spinal dorsal horn.
Eiichi Kumamoto
doaj   +1 more source

Hypothalamic orexinergic neuron changes during the hibernation of the Syrian hamster

Frontiers in Neuroanatomy, 2022
Hibernation in small mammals is a highly regulated process with periods of torpor involving drops in body temperature and metabolic rate, as well as a general decrease in neural activity, all of which proceed alongside complex brain adaptive changes that
Jesús M. López, Paula Carballeira, Javier Pozo, Gonzalo León-Espinosa, Alberto Muñoz, Alberto Muñoz, Alberto Muñoz   +6 more
doaj   +1 more source

Orexins and stress [PDF]

Frontiers in Neuroendocrinology, 2018
The neuropeptides orexins are important in regulating the neurobiological systems that respond to stressful stimuli. Furthermore, orexins are known to play a role many of the phenotypes associated with stress-related mental illness such as changes in cognition, sleep-wake states, and appetite.
Laura A, Grafe, Seema, Bhatnagar
openaire   +2 more sources

Research progress on the mechanism of orexin in pain regulation in different brain regions

Open Life Sciences, 2021
Orexin is a neuropeptide that is primarily synthesized and secreted by the lateral hypothalamus (LH) and includes two substances derived from the same precursor (orexin A [OXA] and orexin B [OXB]).
Kang Xianhui, Tang Hongli, Liu Yao, Yuan Yan, Wang Mi   +4 more
doaj   +1 more source

Increased Numbers of CD4+ T‐Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1

Annals of Neurology, EarlyView.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11‐fold increase of CD4+ T‐cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T‐cells.
Ling Shan, Milo Fonville, Mabel Hoekstra, Rolf Fronczek, Joost Smolders, Dick F. Swaab   +5 more
wiley   +1 more source

A Comparative Analysis of Orexins in the Physio-Pathological Processes of the Male Genital Tract: New Challenges? A Review

Veterinary Sciences
Orexins A (OXA) and B (OXB) and their specific receptors, receptor 1 (OX1R) and 2 (OX2R) for orexins, are hypothalamic peptides involved in orchestrating several functions in the central nervous system and peripheral organs, including sleep, excitement ...
Anna Costagliola, Luigi Montano, Emilia Langella, Renato Lombardi, Caterina Squillacioti, Nicola Mirabella, Giovanna Liguori   +6 more
doaj   +1 more source

Potential role of orexin A binding the receptor 1 for orexins in normal and cryptorchid dogs. [PDF]

, 2018
Background: Cryptorchidism is one of the most common birth disorders of the male reproductive system identified in dogs and other mammals. This condition is characterised by the absence of one (unilateral) or both (bilateral) gonads from the scrotum ...
Assisi, L, Costagliola, A, Liguori, G, Mirabella, N., Pelagalli, A, Squillacioti, C, Vittoria, A   +6 more
core   +1 more source

Hypnotic doses of fazamorexant induced less impairment on balance and cognition than zolpidem in healthy younger and elderly individualse

British Journal of Clinical Pharmacology, EarlyView.
Aims Fazamorexant is a dual orexin receptor antagonist being developed for the treatment of insomnia. This study aims to determine the dose‐exposure‐response relationship of single‐dose fazamorexant vs. zolpidem in young adult and elderly healthy Chinese volunteers. Methods This single‐centre, randomized, double‐blind, double‐dummy, placebo‐ and active‐
Chen Xia, Huang Xingxing, Jin Lu, Wang Ruwei   +3 more
wiley   +1 more source