Structure of the active form of human origin recognition complex and its ATPase motor module [PDF]
eLife, 2017 Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells.
Ante Tocilj +7 more
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Origin recognition complex subunit 6 (ORC6) is a key mediator of LPS-induced NFκB activation and the pro-inflammatory response [PDF]
Cell Communication and SignalingLipopolysaccharide (LPS)-activated pro-inflammatory responses play a critical role in sepsis, a life-threatening condition. This study investigates the role of origin recognition complex subunit 6 (ORC6) in LPS responses in macrophages and monocytes ...
Zichen Xie +4 more
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Depletion of the Origin Recognition Complex Subunits Delays Aging in Budding Yeast [PDF]
Cells, 2022 Precise DNA replication is pivotal for ensuring the accurate inheritance of genetic information. To avoid genetic instability, each DNA fragment needs to be amplified only once per cell cycle.
Karolina Stępień +4 more
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The human origin recognition complex is essential for pre-RC assembly, mitosis, and maintenance of nuclear structure [PDF]
eLife, 2021 The origin recognition complex (ORC) cooperates with CDC6, MCM2-7, and CDT1 to form pre-RC complexes at origins of DNA replication. Here, using tiling-sgRNA CRISPR screens, we report that each subunit of ORC and CDC6 is essential in human cells. Using an
Hsiang-Chen Chou +12 more
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Rethinking origin licensing [PDF]
eLife, 2017 Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
Stephen P Bell
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Identification of ORC1/CDC6-interacting factors in Trypanosoma brucei reveals critical features of origin recognition complex architecture. [PDF]
PLoS ONE, 2012 DNA replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Calvin Tiengwe +7 more
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Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression [PDF]
Frontiers in Immunology, 2023 BackgroundOrigin recognition complex 6 (ORC6) is one of the six highly conserved subunit proteins required for DNA replication and is essential for maintaining genome stability during cell division.
Jinfeng Zhu +23 more
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Association with the origin recognition complex suggests a novel role for histone acetyltransferase Hat1p/Hat2p [PDF]
BMC Biology, 2007 Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 ...
Greenblatt Jack F +7 more
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Systemic analysis of the DNA replication regulator origin recognition complex in lung adenocarcinomas identifies prognostic and expression significance [PDF]
Cancer Medicine, 2023 Background DNA replication alteration is a hallmark of patients with lung adenocarcinoma (LUAD) and is frequently observed in LUAD progression. Origin recognition complex (ORC) 1, ORC2, ORC3, ORC4, ORC5, and ORC6 form a replication–initiator complex to ...
Min Tang +6 more
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Origin recognition complex subunit 1 functions as an oncogenic driver and therapeutic target in cancer [PDF]
Discover OncologyORC1 is a core protein governing DNA replication initiation and cell cycle regulation, exhibiting significant overexpression in multiple malignancies where it correlates with advanced disease stage and poor prognosis.
Yixuan Ding +4 more
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