Results 31 to 40 of about 196,060 (141)
Assembly of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2001 The six-subunit origin recognition complex (ORC) was originally identified in the yeast Saccharomyces cerevisiae. Yeast ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors, such as Cdc6 and the Mcm proteins.
S, Vashee +3 more
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eLife, 2013 In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins.
Franziska Bleichert +5 more
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The origin recognition complex: from simple origins to complex functions [PDF]
Genes & Development, 2002 Eukaryotic DNA replication is an intricate process that requires the coordinate and tightly regulated action of numerous molecular machines. Eukaryotic cells must choose hundreds if not thousands of origins of replication and assemble multiple proteins or protein complexes at these sites. During S phase, these complexes are activated in a reproducible,
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International Journal of General Medicine, 2021 Shaohua Chen,1,2 Ziyao Jin,3 Linfeng Xin,4 Lv Lv,2 Xuemei Zhang,3 Yizhen Gong,5 Jianlun Liu1 1Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nangning, People’s Republic of China; 2Department of Breast and Thyroid Surgery ...
Chen S +6 more
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RNA‐dependent recruitment of the origin recognition complex [PDF]
The EMBO Journal, 2008 The origin recognition complex (ORC) has an important function in determining the initiation sites of DNA replication. In higher eukaryotes, ORC lacks sequence-specific DNA binding, and the mechanisms of ORC recruitment and origin determination are poorly understood.
Julie, Norseen +5 more
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Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]
PLoS Genetics, 2010 Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz +2 more
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Abnormally proximal aortic origin of the brachiocephalic artery: Surgical implications
Annals of Pediatric Cardiology, 2022 Abnormal proximal aortic origin of the brachiocephalic artery is a very rare condition. It can occur in isolation or associated with complex congenital heart disease affecting the right ventricular outflow tract. Its recognition carries relevant surgical
Sudesh Prabhu +5 more
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eLife, 2015 Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs).
Sumanprava Giri +10 more
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DNA replication origins retain mobile licensing proteins
Nature Communications, 2021 Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates ...
Humberto Sánchez +7 more
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The role of adenosine triphosphate in the function of human origin recognition complex 4 protein [PDF]
Journal of the Serbian Chemical Society, 2010 Human origin recognition complex 4 (ORC4) protein, a subunit of the origin recognition complex, belongs to the AAA+ superfamily of adenosine triphosphate (ATP) ases.
ALEKSANDRA DIVAC +2 more
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