Results 31 to 40 of about 1,052,584 (308)
Elevated origin recognition complex subunit 6 expression promotes non-small cell lung cancer cell growth [PDF]
Cell Death and DiseaseExploring novel targets for non-small cell lung cancer (NSCLC) remains of utmost importance. This study focused on ORC6 (origin recognition complex subunit 6), investigating its expression and functional significance within NSCLC.
Yong-hua Sang +6 more
doaj +2 more sources
The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2. [PDF]
PLoS Pathogens, 2016 The origin recognition complex (ORC) coordinates a series of events that lead to initiation of DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV) genome resembles a mini-chromosome in infected cells. To initiate its
Marsha DeSmet +5 more
doaj +5 more sources
Origin recognition complex harbors an intrinsic nucleosome remodeling activity. [PDF]
Proc Natl Acad Sci U S A, 2022 Eukaryotic DNA replication is initiated at multiple chromosomal sites known as origins of replication that are specifically recognized by the origin recognition complex (ORC) containing multiple ATPase sites. In budding yeast, ORC binds to specific DNA sequences known as autonomously replicating sequences (ARSs) that are mostly nucleosome ...
Li S +5 more
europepmc +3 more sources
Ordered and disordered regions of the Origin Recognition Complex (ORC) combine to direct in-vivo binding at symmetric and non-symmetric motif sequences [PDF]
Chappleboim M +4 more
europepmc +2 more sources
Delayed recognition of complex staphylococcal infection in pyrexia of unknown origin
The Indian Anaesthetists' Forum, 2020 Vanita Ahuja +3 more
doaj +2 more sources
Nonreplicative functions of the origin recognition complex. [PDF]
Nucleus, 2018 Origin recognition complex (ORC), a heteromeric six-subunit complex, is the central component of the eukaryotic pre-replication complex. Recent data from yeast, frogs, flies and mammals present compelling evidence that ORC and its individual subunits have nonreplicative functions as well.
Popova VV +3 more
europepmc +4 more sources
The metazoan origin recognition complex [PDF]
Frontiers in Bioscience, 1999 Regulated initiation of DNA replication relies on the firing of initiator proteins that bind specifically to origin DNA. The discovery of the first eukaryotic initiator, the Saccharomyces cerevisiae Origin Recognition Complex (ORC) has allowed us to discern some aspects of how the onset of replication is regulated.
D G, Quintana, A, Dutta
openaire +2 more sources