Results 31 to 40 of about 1,024,488 (281)

A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation

eLife, 2013
In eukaryotes, DNA replication requires the origin recognition complex (ORC), a six-subunit assembly that promotes replisome formation on chromosomal origins.
Franziska Bleichert, Maxim Balasov, Igor Chesnokov, Eva Nogales, Michael R Botchan, James M Berger   +5 more
doaj   +1 more source

Mechanism of DNA Recognition at a Viral Replication Origin [PDF]

, 2006
Recognition of the DNA origin by the Epstein-Barr nuclear antigen 1 (EBNA1) protein is the primary event in latentphase genome replication of the Epstein-Barr virus, a model for replication initiation in eukaryotes.
de Prat Gay, Gonzalo, Frappier, Lori, Freire Espeleta, Eleonora, Oddo, Cristian   +3 more
core   +1 more source

Expression and Clinical Significance of Origin Recognition Complex Subunit 6 in Breast Cancer – A Comprehensive Bioinformatics Analysis

International Journal of General Medicine, 2021
Shaohua Chen,1,2 Ziyao Jin,3 Linfeng Xin,4 Lv Lv,2 Xuemei Zhang,3 Yizhen Gong,5 Jianlun Liu1 1Department of Breast Surgery, Guangxi Medical University Cancer Hospital, Nangning, People’s Republic of China; 2Department of Breast and Thyroid Surgery ...
Chen S, Jin Z, Xin L, Lv L, Zhang X, Gong Y, Liu J   +6 more
doaj  

Cdc6 ATPase activity regulates ORC center dot Cdc6 stability and the selection of specific DNA sequences as origins of DNA replication [PDF]

, 2007
DNA replication, as with all macromolecular synthesis steps, is controlled in part at the level of initiation. Although the origin recognition complex ( ORC) binds to origins of DNA replication, it does not solely determine their location.
Speck, C., Stillman, B.
core   +1 more source

Diversity of eukaryotic DNA replication origins revealed by genome-wide analysis of chromatin structure. [PDF]

PLoS Genetics, 2010
Eukaryotic DNA replication origins differ both in their efficiency and in the characteristic time during S phase when they become active. The biological basis for these differences remains unknown, but they could be a consequence of chromatin structure ...
Nicolas M Berbenetz, Corey Nislow, Grant W Brown   +2 more
doaj   +1 more source

The dynamics of replication licensing in live Caenorhabditis elegans embryos [PDF]

, 2012
Accurate DNA replication requires proper regulation of replication licensing, which entails loading MCM-2-7 onto replication origins. In this paper, we provide the first comprehensive view of replication licensing in vivo, using video microscopy of ...
Anton Gartner, Ashley Craig, Baldinger, Blow, Blow, Brauchle, Brenner, Cheeseman, Chen, Clarey, Clarey, DePamphilis, Drury, Edgar, Encalada, Evrin, Galy, Gambus, Gillespie, Hadwiger, Harvey, Ilves, J. Julian Blow, Kamath, Kim, Kisielewska, Korzelius, Kuipers, Li, Li, Li, Liu, Matthieu Querenet, McNairn, McNally, Moyer, Oehlmann, Praitis, Prokhorova, Quinn, Randell, Remi Sonneville, Remus, Rothbauer, Rowles, Shelton, Siddiqui, Speck, Sönnichsen, Tada, Timmons, Waga, Wallenfang, Wohlschlegel, Yanagi, Yang, Zhong   +56 more
core   +4 more sources

Mechanism and timing of Mcm2–7 ring closure during DNA replication origin licensing [PDF]

, 2017
The opening and closing of two ring-shaped Mcm2-7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear.
A Costa, A Fernández-Cid, A Schepers, AA Hoskins, AY Lyubimov, BA Kelch, BA Smith, C Evrin, D Remus, DJ Crawford, F Chang, G Coster, H Yardimci, I Chen, Ivan R Corrêa, J Frigola, J Sun, J Sun, JCW Randell, Jeff Gelles, JL Bowers, JTP Yeeles, Kanokwan Champasa, Larry J Friedman, LJ Friedman, LJ Friedman, LJ Friedman, M Kindermann, ML Bochman, N Li, OM Aparicio, RY Samson, S Donovan, S Kang, S Ticau, SA Samel, Simina Ticau, SP Bell, Stephen P Bell, TD Deegan   +39 more
core   +5 more sources

Abnormally proximal aortic origin of the brachiocephalic artery: Surgical implications

Annals of Pediatric Cardiology, 2022
Abnormal proximal aortic origin of the brachiocephalic artery is a very rare condition. It can occur in isolation or associated with complex congenital heart disease affecting the right ventricular outflow tract. Its recognition carries relevant surgical
Sudesh Prabhu, Sruti Rao, Satheesh Siddaiah, Balasubramanian Shanmugasundaram, Tom R Karl, Annalisa Angelini   +5 more
doaj   +1 more source

Functions of sensor 1 and sensor 2 regions of Saccharomyces cerevisiae Cdc6p in vivo and in vitro [PDF]

, 2002
Cdc6p is a key regulator of the cell cycle in eukaryotes and is a member of the AAA(+) (ATPases associated with a variety of cellular activities) family of proteins.
Mizushima, T., Stillman, B., Takahashi, N., Tsuchiya, T., Tsutsumi, S.   +4 more
core   +1 more source

DNA replication origins retain mobile licensing proteins

Nature Communications, 2021
Eukaryotic DNA replication is regulated to ensure copying of the genome (only) once per cell cycle. Here the authors, using optical trapping and confocal microscopy, demonstrate the dynamics of the origin recognition complex and subsequent intermediates ...
Humberto Sánchez, Kaley McCluskey, Theo van Laar, Edo van Veen, Filip M. Asscher, Belén Solano, John F. X. Diffley, Nynke H. Dekker   +7 more
doaj   +1 more source