Results 41 to 50 of about 196,060 (141)
eLife, 2017 Human cells that lack a subunit in their origin recognition complex are viable, which suggests the existence of alternative mechanisms to initiate DNA replication.
Stephen P Bell
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Target Recognition of SAR Image Based on CN-GAN and CNN in Complex Environment
IEEE Access, 2021 In recent years, with the rapid development of deep learning, the research of radar image automatic target recognition (ATR) has made great progress. However, because of the complex environments and special imaging principles, Synthetic Aperture Radar ...
Cong Mao +4 more
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ATP-dependent Assembly of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2007 The origin recognition complex (ORC) was initially discovered in budding yeast extracts as a protein complex that binds with high affinity to autonomously replicating sequences in an ATP-dependent manner. We have cloned and expressed the human homologs of the ORC subunits as recombinant proteins. In contrast to other eukaryotic initiators examined thus
Khalid, Siddiqui, Bruce, Stillman
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BMC Biology, 2007 Background Histone modifications have been implicated in the regulation of transcription and, more recently, in DNA replication and repair. In yeast, a major conserved histone acetyltransferase, Hat1p, preferentially acetylates lysine residues 5 and 12 ...
Greenblatt Jack F +7 more
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Structure and function of the Orc1 BAH-nucleosome complex
Nature Communications, 2019 The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with ...
Pablo De Ioannes +6 more
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Interaction between HMGA1a and the origin recognition complex creates site-specific replication origins [PDF]
Proceedings of the National Academy of Sciences, 2008 In all eukaryotic cells, origins of DNA replication are characterized by the binding of the origin recognition complex (ORC). How ORC is positioned to sites where replication initiates is unknown, because metazoan ORC binds DNA without apparent sequence specificity. Thus, additional factors might be involved in ORC positioning.
Andreas W, Thomae +7 more
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eLife, 2021 Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork ...
Nina Kirstein +11 more
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Architecture of the Yeast Origin Recognition Complex Bound to Origins of DNA Replication [PDF]
Molecular and Cellular Biology, 1997 In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as origins of replication. Analyses of multiple initiator proteins bound to their cognate origins have provided important insights into the mechanism by which DNA replication is initiated.
D G, Lee, S P, Bell
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Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]
PLoS ONE, 2014 Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz +2 more
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The Origin Recognition Complex Marks a Replication Origin in the Human TOP1 Gene Promoter [PDF]
Journal of Biological Chemistry, 2002 The locations of the origin recognition complex (ORC) in mammalian genomes have been elusive. We have therefore analyzed the DNA sequences associated with human ORC via in vivo cross-linking and chromatin immunoprecipitation. Antibodies specific for hOrc2 protein precipitate chromatin fragments that also contain other ORC proteins, suggesting that the ...
Christian, Keller +3 more
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