Results 41 to 50 of about 1,052,584 (308)
Crystal structure of the eukaryotic origin recognition complex. [PDF]
Nature, 2015 Initiation of cellular DNA replication is tightly controlled to sustain genomic integrity. In eukaryotes, the heterohexameric origin recognition complex (ORC) is essential for coordinating replication onset. Here we describe the crystal structure of Drosophila ORC at 3.5 Å resolution, showing that the 270 kilodalton initiator core complex comprises a ...
Bleichert F, Botchan MR, Berger JM.
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The origin recognition complex protein family. [PDF]
Genome Biol, 2009 Origin recognition complex (ORC) proteins were first discovered as a six-subunit assemblage in budding yeast that promotes the initiation of DNA replication. Orc1-5 appear to be present in all eukaryotes, and include both AAA+ and winged-helix motifs.
Duncker BP, Chesnokov IN, McConkey BJ.
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Origin recognition complex binding to a metazoan replication origin [PDF]
Current Biology, 2001 The initiation of DNA replication in eukaryotic cells at the onset of S phase requires the origin recognition complex (ORC) [1]. This six-subunit complex, first isolated in Saccharomyces cerevisiae [2], is evolutionarily conserved [1]. ORC participates in the formation of the prereplicative complex [3], which is necessary to establish replication ...
Bielinsky, Anja-Katrin +6 more
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The remarkable gymnastics of ORC
eLife, 2022 As a cell prepares to divide, a molecular actor known as the Origin Recognition Complex makes intricate ATP-driven movements to recruit proteins required to duplicate DNA.
Bruce Stillman
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The origin recognition complex in human diseases. [PDF]
Biosci Rep, 2013 ORC (origin recognition complex) serves as the initiator for the assembly of the pre-RC (pre-replication complex) and the subsequent DNA replication. Together with many of its non-replication functions, ORC is a pivotal regulator of various cellular processes.
Shen Z.
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Nature Communications, 2023 Chromatin replication involves the assembly and activity of the replisome within the nucleosomal landscape. At the core of the replisome is the Mcm2-7 complex (MCM), which is loaded onto DNA after binding to the Origin Recognition Complex (ORC). In yeast,
Humberto Sánchez +5 more
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Identification of a Novel 81-kDa Component of the Xenopus Origin Recognition Complex [PDF]
, 1998 The Xenopus origin recognition complex is essential for chromosomal DNA replication in cell-free extracts. We have immunopurified the Xenopus origin recognition complex with anti-Xorc2 antibodies and analyzed its composition and properties.
Carpenter, Phillip B. +1 more
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Architecture of the Human Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2001 All the human homologs of the six subunits of Saccharomyces cerevisiae origin recognition complex have been reported so far. However, not much has been reported on the nature and the characteristics of the human origin recognition complex. In an attempt to purify recombinant human ORC from insect cells infected with baculoviruses expressing HsORC ...
S K, Dhar, L, Delmolino, A, Dutta
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Purification and Characterization of theSchizosaccharomyces pombe Origin Recognition Complex [PDF]
Journal of Biological Chemistry, 2002 Ray-Yuan Chuang +3 more
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Nature Communications, 2023 The dynamics of DNA replication factors is crucial for cell cycle progression. Arabidopsis encode two origin recognition complex 1 proteins, ORC1a and ORC1b, with distinct roles in DNA replication and deposition of heterochromatic H3K27me1, respectively.
Zaida Vergara +10 more
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