Results 51 to 60 of about 1,024,488 (281)

Structure and function of the Orc1 BAH-nucleosome complex

Nature Communications, 2019
The Origin Recognition Complex (ORC) plays conserved and diverse roles in eukaryotes. Here the authors present the structure of a chromatin interacting domain of yeast Orc1 in complex with the nucleosome core particle, revealing that Orc1 interacts with ...
Pablo De Ioannes, Victor A. Leon, Zheng Kuang, Miao Wang, Jef D. Boeke, Andreas Hochwagen, Karim-Jean Armache   +6 more
doaj   +1 more source

Evolutionary interplay between viruses and R‐loops

FEBS Letters, EarlyView.
Viruses interact with specialized nucleic acid structures called R‐loops to influence host transcription, epigenetic states, latency, and immune evasion. This Perspective examines the roles of R‐loops in viral replication, integration, and silencing, and how viruses co‐opt or avoid these structures.
Zsolt Karányi, Zita Képes, Zoltán Szabó, Eszter Csoma, Lóránt Székvölgyi   +4 more
wiley   +1 more source

Iridium complex, a phosphorescent light-emitting diode material, serves as a novel chemical probe for imaging hypoxic tumor tissues [PDF]

, 2007
Iridium complex, a promising organic light-emitting diode for next generation television displays, emits phosphorescence. Phosphorescence is quenched by oxygen. We used this oxygen-quenching feature for imaging tumor hypoxia.
Keigo Endo, Masahiro Hosaka, Seiji Tobita, Shaojuan Zhang, Toshitada Yoshihara, Toshiyuki Takeuchi, Yasuhiko Iida   +6 more
core   +1 more source

Habitability on Mars from a Microbial Point of View [PDF]

, 2013
International audienceExtraterrestrial habitability is a complex notion. We briefly review what is known about the origin of life on Earth, that is, life based on carbon chemistry and water.
Bertrand, Marylène, Bost, Nicolas, Foucher, Frédéric, Kminek, Gerhard, Loizeau, D., Vago, Jorge, Westall, Francès   +6 more
core   +3 more sources

Human ORC/MCM density is low in active genes and correlates with replication time but does not delimit initiation zones

eLife, 2021
Eukaryotic DNA replication initiates during S phase from origins that have been licensed in the preceding G1 phase. Here, we compare ChIP-seq profiles of the licensing factors Orc2, Orc3, Mcm3, and Mcm7 with gene expression, replication timing, and fork ...
Nina Kirstein, Alexander Buschle, Xia Wu, Stefan Krebs, Helmut Blum, Elisabeth Kremmer, Ina M Vorberg, Wolfgang Hammerschmidt, Laurent Lacroix, Olivier Hyrien, Benjamin Audit, Aloys Schepers   +11 more
doaj   +1 more source

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication. [PDF]

PLoS Pathogens, 2009
The EBNA1 protein of Epstein-Barr virus (EBV) plays essential roles in enabling the replication and persistence of EBV genomes in latently infected cells and activating EBV latent gene expression, in all cases by binding to specific recognition sites in ...
Feroz Sarkari, Teresa Sanchez-Alcaraz, Shan Wang, Melissa N Holowaty, Yi Sheng, Lori Frappier   +5 more
doaj   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

Error thresholds for self- and cross-specific enzymatic replication [PDF]

, 2010
The information content of a non-enzymatic self-replicator is limited by Eigen's error threshold. Presumably, enzymatic replication can maintain higher complexity, but in a competitive environment such a replicator is faced with two problems related to ...
Acevedo, Alves, Baake, Benedikt Obermayer, Blythe, Campos, Cech, de Oliveira, Doudna, Eigen, Eigen, Erwin Frey, Fernando, Fontanari, Galluccio, Gerland, Gilbert, Hermisson, Huynen, Johnston, Joyce, Komarova, Kun, Leuthäusser, Lilley, Lincoln, Lässig, Maynard Smith, Michod, Nowak, Obermayer, Orgel, Orgel, Pace, Peliti, Rajamani, Rawlings, Saakian, Saakian, Schuster, Stadler, Stadler, Summers, Swetina, Szathmáry, Szostak, Takeuchi, Takeuchi, von Kiedrowski, Wagner, Weiner, Wiehe, Wilke, Wilke, Woodcock, Wu, Zaher   +56 more
core   +4 more sources

Initiation of DNA replication from non-canonical sites on an origin-depleted chromosome. [PDF]

PLoS ONE, 2014
Eukaryotic DNA replication initiates from multiple sites on each chromosome called replication origins (origins). In the budding yeast Saccharomyces cerevisiae, origins are defined at discrete sites.
Naomi L Bogenschutz, Jairo Rodriguez, Toshio Tsukiyama   +2 more
doaj   +1 more source