Results 51 to 60 of about 196,060 (141)
PLoS ONE, 2012 DNA replication initiates by formation of a pre-replication complex on sequences termed origins. In eukaryotes, the pre-replication complex is composed of the Origin Recognition Complex (ORC), Cdc6 and the MCM replicative helicase in conjunction with ...
Calvin Tiengwe +7 more
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RNAP-II molecules participate in the anchoring of the ORC to rDNA replication origins. [PDF]
PLoS ONE, 2013 The replication of genomic DNA is limited to a single round per cell cycle. The first component, which recognises and remains bound to origins from recognition until activation and replication elongation, is the origin recognition complex.
Maria D Mayan
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Cell Cycle Dependent Regulation of the Origin Recognition Complex [PDF]
Cell Cycle, 2004 The eukaryotic origin recognition complex (ORC) not only selects the sites where prereplication complexes are assembled and DNA replication begins, it is the first in a series of multiple coherent pathways that determines when prereplication complexes are assembled. Data from yeast, frogs, flies and mammals present a compelling case that one or more of
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Cell Reports, 2013 The DNA tumor virus Simian virus 40 (SV40) is a model system for studying eukaryotic replication. SV40 large tumor antigen (LTag) is the initiator/helicase that is essential for genome replication.
Y. Paul Chang +5 more
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The origin recognition complex is dispensable for endoreplication in Drosophila [PDF]
Proceedings of the National Academy of Sciences, 2008 The origin recognition complex (ORC) is an essential component of the prereplication complex (pre-RC) in mitotic cell cycles. The role of ORC as a foundation to assemble the pre-RC is conserved from yeast to human. Furthermore, in metazoans ORC plays a key role in determining the timing of replication initiation and origin usage ...
So Young, Park, Maki, Asano
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Assembly of functionally active Drosophila origin recognition complex from recombinant proteins [PDF]
Genes & Development, 1999 In eukaryotes the sites for the initiation of chromosomal DNA replication are believed to be determined in part by the binding of a heteromeric origin recognition complex (ORC) to DNA. We have cloned the genes encoding the subunits of the Drosophila ORC.
I, Chesnokov +3 more
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PLoS Genetics, 2009 The origin recognition complex (ORC) marks chromosomal sites as replication origins and is essential for replication initiation. In yeast, ORC also binds to DNA elements called silencers, where its primary function is to recruit silent information ...
Erika Shor +13 more
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The Origin Recognition Complex: where it all begins
The FASEB Journal, 2018 Binding of the Origin Recognition Complex (ORC) to origins of replication marks the first step in the initiation of replication of the genome in all eukaryotic cells. I will present the structure of the active form of human ORC determined by X‐ray crystallography and cryo‐electron microscopy.
Leemor Joshua‐Tor +6 more
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A new class of disordered elements controls DNA replication through initiator self-assembly
eLife, 2019 The initiation of DNA replication in metazoans occurs at thousands of chromosomal sites known as origins. At each origin, the Origin Recognition Complex (ORC), Cdc6, and Cdt1 co-assemble to load the Mcm2-7 replicative helicase onto chromatin.
Matthew W Parker +6 more
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The Eukaryotic Mismatch Recognition Complexes Track with the Replisome during DNA Synthesis.
PLoS Genetics, 2015 During replication, mismatch repair proteins recognize and repair mispaired bases that escape the proofreading activity of DNA polymerase. In this work, we tested the model that the eukaryotic mismatch recognition complex tracks with the advancing ...
Joanna E Haye, Alison E Gammie
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