Results 61 to 70 of about 196,060 (141)

Chromatin’s Influence on Pre-Replication Complex Assembly and Function

Biology
In all eukaryotes, the initiation of DNA replication requires a stepwise assembly of factors onto the origins of DNA replication. This is pioneered by the Origin Recognition Complex, which recruits Cdc6.
Hina Ahmad, Neha Chetlangia, Supriya G. Prasanth   +2 more
doaj   +1 more source

Diagnostic value of serum origin recognition complex protein 1 in the progression of HBVrelated liver fibrosis

Guangxi Yike Daxue xuebao
Objective To explore the diagnostic value and significance of human serum origin recognition complex protein 1 (ORC1) in the degree of hepatitis B (HBV)-related liver fibrosis. Methods A total of 269 patients with HBV infection admitted to the Department
LIANG Hongqian, HUANG Long, REN Aoli, SU Minghua, HU Bobin, LI Qingmei, SU Tumei, YIN Qianbing, LI Aining, JIANG Jianning   +9 more
doaj   +1 more source

EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication.

PLoS Pathogens, 2009
The EBNA1 protein of Epstein-Barr virus (EBV) plays essential roles in enabling the replication and persistence of EBV genomes in latently infected cells and activating EBV latent gene expression, in all cases by binding to specific recognition sites in ...
Feroz Sarkari, Teresa Sanchez-Alcaraz, Shan Wang, Melissa N Holowaty, Yi Sheng, Lori Frappier   +5 more
doaj   +1 more source

BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication

Nature Communications
Mono-methylation of histone H4 lysine 20 (H4K20me1) regulates DNA replication, cell cycle progression and DNA damage repair. How exactly H4K20me1 regulates these biological processes remains unclear.
Dongxu Li, Zhi-Min Zhang, Liu Mei, Yao Yu, Yiran Guo, Samuel G. Mackintosh, Jianbin Chen, David F. Allison, Arum Kim, Aaron J. Storey, Ricky D. Edmondson, Stephanie D. Byrum, Alan J. Tackett, Ling Cai, Jeanette G. Cook, Jikui Song, Gang Greg Wang   +16 more
doaj   +1 more source

The Replicative Consequences of Papillomavirus E2 Protein Binding to the Origin Replication Factor ORC2.

PLoS Pathogens, 2016
The origin recognition complex (ORC) coordinates a series of events that lead to initiation of DNA strand duplication. As a nuclear double stranded DNA plasmid, the papillomavirus (PV) genome resembles a mini-chromosome in infected cells. To initiate its
Marsha DeSmet, Sriramana Kanginakudru, Anne Rietz, Wai-Hong Wu, Richard Roden, Elliot J Androphy   +5 more
doaj   +1 more source

A dual role for the chromatin reader ORCA/LRWD1 in targeting the origin recognition complex to chromatin. [PDF]

EMBO J, 2023
Sahu S, Ekundayo BE, Kumar A, Bleichert F.   +3 more
europepmc   +1 more source

Diversity and evolution of Amazonian birds: implications for conservation and biogeography

Anais da Academia Brasileira de Ciências
: Amazonia has been a focus of interest since the early days of biogeography as an intrinsically complex and extremely diverse region. This region comprises an intricate mosaic that includes diverse types of forest formations, flooded environments and ...
CAMILA C. RIBAS, ALEXANDRE ALEIXO
doaj   +1 more source

Delayed recognition of complex staphylococcal infection in pyrexia of unknown origin

The Indian Anaesthetists' Forum, 2020
Vanita Ahuja, Kavita Ramakrishna Bhagwat, Pawanpreet Kaur, Karanjot Gill   +3 more
doaj   +1 more source

AlphaFold-guided phylogenetic analyses suggest surprising heterogeneity in metazoan replication origin licensing mechanisms

The EMBO Journal
DNA replication initiation is a tightly regulated process that requires the coordinated assembly of replication machineries throughout the genome. During the first step of initiation, origin licensing, the MCM replicative helicase motor is loaded onto ...
Olivia Hunker, Franziska Bleichert
doaj   +1 more source

Temporal control of human DNA replication licensing by CDK4/6-RB signalling and chemical genetics

Nature Communications
Cyclin-dependent kinases (CDKs) coordinate DNA replication and cell division, and play key roles in tissue homeostasis, genome stability and cancer development.
Anastasia Sosenko Piscitello, Ann-Sofie Nilsson, Michael Hawgood, Abid H. Sayyid, Vasilis S. Dionellis, Giovanni Giglio, Bruno Urién, Pratikiran Bajgain, Sotirios G. Ntallis, Jiri Bartek, Thanos D. Halazonetis, Bennie Lemmens   +11 more
doaj   +1 more source