Decreased sensitivity to aspirin is associated with altered polyamine metabolism in human prostate cancer cells [PDF]
, 2015 Acknowledgments We thank NHS Grampian for financial support of this work.Peer reviewedPublisher ...
Cameron, Gary A. +2 more
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New amphiphilic amino acid derivatives for efficient DNA transfection in vitro [PDF]
, 2017 Nucleic acids-based therapies have recently developed as next-generationagents for treating and preventing viral infection, cancer, and genetic disorders,but their use is still limited due to its relatively poor delivery into targetedcells.
Antuña, Sebastián +7 more
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Synthesis of a Borrelia burgdorferi-Derived Muropeptide Standard Fragment Library
MoleculesThe interplay between the human innate immune system and bacterial cell wall components is pivotal in understanding diseases such as Crohn’s disease and Lyme arthritis.
Rachel Putnik +7 more
doaj +1 more source
Synthetic Vasopressin and Oxytocin Analogs and Their Potential Use in Hemorrhagic, Traumatic and Septic Shock: A Personal Perspective [PDF]
, 2017 As one of us has stated many years ago, “shock is a significant and sustained loss of effective circulating blood volume. It will eventuate in hypoperfusion of critical peripheral tissues, thus leading to a deficit in transcapillary exchange function in ...
Altura BM +3 more
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Modeling non-hereditary mechanisms of Alzheimer disease during apoptosis in yeast
Microbial Cell, 2015 Impaired protein degradation and mitochondrial dysfunction are believed to contribute to neurodegenerative disorders, including Alzheimer disease (AD). In patients suffering from non-hereditary AD, UBB+1, the frameshift variant of ubiquitin B,
Ralf J. Braun +15 more
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AnimalsThe blood vessels of the placenta are crucial for fetal growth. Here, lower vessel density and ornithine (Orn) content were observed in placentae for low-birth-weight fetuses versus normal-birth-weight fetuses at day 75 of gestation. Furthermore, the Orn
Yun Yang +5 more
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Inhibitors of \u3cem\u3eN\u3csup\u3eα\u3c/sup\u3e\u3c/em\u3e-acetyl-l-ornithine Deacetylase: Synthesis, Characterization and Analysis of their Inhibitory Potency [PDF]
, 2010 A series of N α-acyl (alkyl)- and N α-alkoxycarbonyl-derivatives of l- and d-ornithine were prepared, characterized, and analyzed for their potency toward the bacterial enzyme N α-acetyl-l-ornithine deacetylase (ArgE).
Budesinsky, M. +8 more
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From A. rhizogenes RolD to Plant P5CS: Exploiting Proline to Control Plant Development [PDF]
, 2018 The capability of the soil bacterium Agrobacterium rhizogenes to reprogram plant development and induce adventitious hairy roots relies on the expression of a few root-inducing genes (rol A, B, C and D), which can be transferred from large virulence ...
Costantino, Paolo +2 more
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GPRC6A as a novel kokumi receptor responsible for enhanced taste preferences by ornithine
eLifeThe concept of ‘kokumi’, which refers to an enhanced and more delicious flavor of food, has recently generated considerable interest in food science. However, kokumi has not been well studied in gustatory physiology, and the underlying neuroscientific ...
Takashi Yamamoto +6 more
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Behind anticancer molecules: lactoferricin dimeric peptides with fast, selective, persistent and broad-spectrum cytotoxic effect [PDF]
Exploration of Drug ScienceAim: To identify peptides derived from bovine lactoferricin (LfcinB) as potential therapeutics for colon cancer treatment. We systematically modified dimeric peptides to enhance their selectivity against colon cancer cells and reduce toxicity.
Karen Johanna Cárdenas-Martínez +9 more
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