Results 1 to 10 of about 24,134 (239)

Function of Nr4a Orphan Nuclear Receptors in Proliferation, Apoptosis and Fuel Utilization Across Tissues [PDF]

Cells, 2019
The Nr4a family of nuclear hormone receptors is composed of three members—Nr4a1/Nur77, Nr4a2/Nurr1 and Nr4a3/Nor1. While currently defined as ligandless, these transcription factors have been shown to regulate varied processes across a host of ...
Jacob A. Herring, Weston S. Elison, Jeffery S. Tessem   +2 more
doaj   +4 more sources

Targeting Orphan Nuclear Receptors NR4As for Energy Homeostasis and Diabetes [PDF]

Frontiers in Pharmacology, 2020
Orphan nuclear receptors are important members of the nuclear receptor family and may regulate cell proliferation, metabolism, differentiation, and apoptosis.
Chenyang Zhang, Chenyang Zhang, Chenyang Zhang, Chenyang Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Bin Zhang, Xuelian Zhang, Xuelian Zhang, Xuelian Zhang, Xuelian Zhang, Guibo Sun, Guibo Sun, Guibo Sun, Guibo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun, Xiaobo Sun   +19 more
doaj   +2 more sources

Insights into orphan nuclear receptors as prognostic markers and novel therapeutic targets for breast cancer [PDF]

Frontiers in Endocrinology, 2015
The roles of orphan nuclear receptors in breast cancer development and progression are not well understood. In this review, we correlate orphan nuclear receptor expression in breast cancer tumour subtypes with patient outcomes and provide an overview of ...
Reidun eAesoy, Reidun eAesoy, Colin D Clyne, Colin D Clyne, Ashwini eChand, Ashwini eChand, Ashwini eChand   +6 more
doaj   +2 more sources

Analysing the gene expression profiles of the orphan nuclear receptors NR4A1, NR4A2 and NR4A3 in premalignant lesions of the cervix and cervicitis [PDF]

European Journal of Obstetrics & Gynecology and Reproductive Biology: X
Objective: The main objective of the present study was to evaluate the expression of nuclear orphan receptors in the development of Uterine Cervical Cancer (UCC).
Rosa P. Cruz-Nieves, Gladys E. Ramírez-Rosales, Javier González-Ramírez, Fausto Sánchez-Muñoz, Armando Ruiz-Hernández   +4 more
doaj   +2 more sources

Orphan Nuclear Receptors TR2 and TR4 in Erythropoiesis: From Mechanisms to Therapies [PDF]

Biomolecules
Testicular orphan receptors TR2 and TR4 serve as central regulators of erythropoiesis, orchestrating the entire continuum of erythroid progenitor cell proliferation, differentiation, and maturation.
Yunlong Liu, Helian Yang, Mengtian Ren, Qing Yu, Qingyang Xu, Xiuping Fu   +5 more
doaj   +2 more sources

An autoregulatory loop controlling orphan nuclear receptor DAX-1 gene expression by orphan nuclear receptor ERRγ [PDF]

Nucleic Acids Research, 2005
The estrogen receptor-related receptor gamma (ERRgamma/ERR3/NR3B3) is a member of the nuclear receptor superfamily that activates transcription in the absence of ligand. However, the detailed mechanism of gene regulation by ERRgamma is not fully understood.
Park, Yun-Yong, Ahn, Seung-Won, Kim, Hye-Jin, Kim, Jin-Man, Lee, In-Kyu, Kang, Heonjoong, Choi, Hueng-Sik   +6 more
openaire   +6 more sources

Critical Evaluation of the Role of Transcription Factor RAR-Orphan Receptor-γt in the Development of Chronic Inflammatory Dermatological Diseases: A Promising Therapeutic Target [PDF]

Biomolecules
Nuclear receptors (NRs) are transcription factors regulated by ligands that direct metabolism, development, and immunity. The NR superfamily constitutes a principal category of pharmacological targets for human ailments.
Anik Pramanik, Pallabi Mondal, Sankar Bhattacharyya   +2 more
doaj   +2 more sources

The metabolic dysfunction-associated steatohepatitis (MASH) drug resmetirom exhibits broad nuclear receptor activity with minimal functional impact [PDF]

Scientific Reports
In 2024, the FDA granted approval for resmetirom, a selective but moderately potent agonist of the thyroid hormone receptor (THR) β, marking the first drug for the treatment of metabolic dysfunction-associated steatohepatitis (MASH) in the US.
Annette Kärcher, Laura Isigkeit, Nils Christiaan Bandomir, Manfred Schubert-Zsilavecz, Pascal Heitel   +4 more
doaj   +2 more sources

The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects [PDF]

Annals of Medicine
Background The global rise in aging populations has substantially increased the clinical and socioeconomic burden of osteoporosis (OP), a disorder characterized by impaired bone formation and excessive resorption.
Liangsheng Wei, Qiaoning Yue, Dayong Yang, Shaogang Miao, Mingyao Lu, Zidan Zhang, Xiaoyan Liang, Xiguang Zhang, Yi Zhang   +8 more
doaj   +2 more sources

Orphan nuclear receptors in drug discovery. [PDF]

Drug Discov Today, 2007
Orphan nuclear receptors provide a unique resource for uncovering novel regulatory systems that impact human health and also provide drug targets for a variety of human diseases. Ligands of nuclear receptors have been used in several important therapeutic areas, such as breast cancers, skin disorders and diabetes.
Shi Y.
europepmc   +4 more sources