Results 131 to 140 of about 65,828 (262)

Mangiferin positively regulates osteoblast differentiation and suppresses osteoclast differentiation

Molecular Medicine Reports, 2017
Mangiferin is a polyphenolic compound present in Salacia reticulata. It has been reported to reduce bone destruction and inhibit osteoclastic differentiation. This study aimed to determine whether mangiferin directly affects osteoblast and osteoclast proliferation and differentiation, and gene expression in MC3T3‑E1 osteoblastic cells and osteoclast ...
Sekiguchi, Yuusuke, Mano, Hiroshi, Nakatani, Sachie, Shimizu, Jun, Kataoka, Aya, Ogura, Kana, Kimira, Yoshifumi, Ebata, Midori, Wada, Masahiro   +8 more
openaire   +3 more sources

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Journal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis, Kelly Galisteu‐Luiz, Gabriela Leite Pedroso, Gustavo Lopes Puls, Leticia Cassaro, Bruno Boaventura Vieira, Fábio Lourenço Romano, Erika Calvano Küchler, Christian Kirschneck, Daniela Silva Barroso de Oliveira, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto   +11 more
wiley   +1 more source

Vascular Reconstruction in Extremity Soft Tissue Sarcomas: A Systematic Review and Single‐Arm Meta‐Analysis

Journal of Surgical Oncology, EarlyView.
ABSTRACT Introduction The management of extremity soft tissue sarcomas (STS) involving major vessels presents unique challenges, historically leading to amputation. Advances in vascular reconstruction have enabled limb‐sparing surgery (LSS), but outcomes and perioperative risks remain uncertain.
Lucas Monteiro Delgado, Bernardo Fontel Pompeu, Vinícius dos Santos Macedo, Gabriel Henrique Acedo Martins, Eric Pasqualotto, Matheus Reginato Araujo, Julia Hoici Brunini, Victor Andrade Nunes, Cláudia Theis, Samuel Aguiar Junior   +9 more
wiley   +1 more source

Convergence of TGFβ and BMP signaling in regulating human bone marrow stromal cell differentiation

Scientific Reports, 2019
Targeting regulatory signaling pathways that control human bone marrow stromal (skeletal or mesenchymal) stem cell (hBMSC) differentiation and lineage fate determination is gaining momentum in the regenerative medicine field.
Mona Elsafadi, Tasneem Shinwari, Sami Al-Malki, Muthurangan Manikandan, Amer Mahmood, Abdullah Aldahmash, Musaad Alfayez, Moustapha Kassem, Nehad M. Alajez   +8 more
doaj   +1 more source

Serum markers of bone fragility in type-2 diabetes mellitus [PDF]

, 2019
Patients with type-2 diabetes mellitus (T2DM) have normal or increased bone mineral density (BMD) but despite that, they are characterized by an increased hip and vertebral fracture risk that involves the alteration of bone quality and not the reduction ...
Dănciulescu Miulescu, Rucsandra, Guja, Loreta, Ochiana, Lavinia Claudia, Ungurianu, Anca, Șeremet, Oana Cristina, Ștefănescu, Emil   +5 more
core   +1 more source

Valproic Acid Inhibits Ferroptosis and Improves Bone Integration in OVX Rats Through the AMPK/SIRT1 Pathway

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT The prevalence of postmenopausal osteoporosis (PMOP) has been steadily increasing. Ferroptosis has been recognized as a critical factor influencing the bone‐forming ability of bone marrow mesenchymal stem cells (BMSCs). Valproic acid (VPA), an HDAC inhibitor, has been suggested to play a role in regulating osteoporosis development; however ...
Qing‐Song Gu, Yi‐Fan Gu, Jian‐Qiao Li, Yi‐Heng Li, Yu‐Hu Chen, Lin‐Hui Wang, Zi‐Ru Wang, Yi‐Cong Wang, Min Yang   +8 more
wiley   +1 more source

Immunological Evaluation of PLLA/GO Scaffolds in Goat Mandibular Bone Regeneration

Macromolecular Bioscience, EarlyView.
PLLA/GO scaffolds interact with bone tissue by modulating the immune response and promoting regeneration in goat mandibles. Histological and immunohistochemical analyses reveal progressive tissue organization, mineral deposition, osteoblastic activity, and angiogenesis over time.
Thamires Santos‐Silva, Fernando Gonçalves da Silva Petrônio, Inácio Silva Viana, Raí André Querino Candelaria, Ana Caroline dos Santos, Paulo Alescio Canola, Luís Gustavo Gosuen G. Dias, Rodrigo da Silva Nunes Barreto, Michel Matar, Marcelo Melo Soares, Maria Angelica Miglino   +10 more
wiley   +1 more source

Synthesis of Bioactive Glass Doped With Bismuth, Zinc, and Copper for Bone Regeneration: Structural and Hemodynamic Analysis Employing ANSYS Static Structural and Fluent Modeling

Nano Select, EarlyView.
Schematic representation of Bi–Zn–Cu doped bioactive glass synthesis, scaffold modelling, and computational analyses for bone tissue engineering and targeted radiotherapy applications in bone malignancies. ABSTRACT Bioactive glasses (BG) are heavily explored biomaterials especially for their bone and tissue regenerative property and biocompatibility ...
Anindita Adri, Nayeem Bin Zahid, Nazmul Hossain, Md Sahadath Hossain, Samina Ahmed, Abul Arafat, Sabrin A. Samad   +6 more
wiley   +1 more source

Platelet-released supernatant induces osteoblastic differentiation of human mesenchymal stem cells: potential role of BMP-2 [PDF]

European Cells & Materials, 2010
Platelet-rich preparations have recently gained popularity in maxillofacial and dental surgery, but their beneficial effect is still under debate. Furthermore, very little is known about the effect of platelet preparations at the cellular level, and the ...
M Alini, P Heini, T Stol, TR Meury, L Kupcsik, S Verrier   +5 more
doaj  

Hidden Insights: Comprehensive Radiological Analysis of Four Skeletal Populations From 13th–19th Century Southern Finland Reveals Neoplastic and Other Lesions Invisible on Bone Surfaces

International Journal of Osteoarchaeology, EarlyView.
ABSTRACT This study aims to identify lesions confined to the internal structures of bones. A radiographic analysis was performed on 219 archaeological, historical period skeletons from southern Finland. Although the study examines nearly all preserved skeletal elements using plain radiographs, it does not incorporate computed tomography.
Kati Salo, Anna Föhr, Rimantas Jankauskas   +2 more
wiley   +1 more source