Results 151 to 160 of about 894,587 (193)

MEK5 suppresses osteoblastic differentiation

Biochemical and Biophysical Research Communications, 2015
Extracellular signal-regulated kinase 5 (ERK5) is a member of the mitogen-activated protein kinase (MAPK) family and is activated by its upstream kinase, MAPK kinase 5 (MEK5), which is a member of the MEK family. Although the role of MEK5 has been investigated in several fields, little is known about its role in osteoblastic differentiation.
Shoichi, Kaneshiro, Dai, Otsuki, Kiyoshi, Yoshida, Hideki, Yoshikawa, Chikahisa, Higuchi   +4 more
openaire   +2 more sources

Proteomic profiling of differentiating osteoblasts

Expert Review of Proteomics, 2006
The major event that triggers osteogenesis is the transition of mesenchymal stem cells into bone-forming, differentiating osteoblast cells. Osteoblast differentiation is the primary event of bone formation, exemplified by the synthesis, deposition and mineralization of extracellular matrix. Osteoblast differentiation is controlled tightly by sequential
Josip, Blonder, Zhen, Xiao, Timothy D, Veenstra   +2 more
openaire   +2 more sources

Insulin facilitates osteoblast differentiation

Cell Biology International, 2013
AbstractTissue engineering of bone has been increasingly used in the bone defect repair. To generate osteoblasts is a major approach, and here we have examined ways of improving the efficiency of producing osteoblasts. Adipose stem cells (ADSC) were prepared from rat mesentery tissue, and transfected with Cbfa1 gene vector or/and IGF‐1R gene vector ...
Lin, Wang, Hongwei, Wang, Xia, Xu, Dongshen, Wang, Hongchen, Liu   +4 more
openaire   +2 more sources

Differentiation of Osteoblasts on Pectin-Coated Titanium

Biomacromolecules, 2008
The gold standard for implant metals is titanium, and coatings such as collagen-I, RGD-peptide, chondroitin sulfate, and calcium phosphate have been used to modify its biocompatibility. We investigated how titanium coated with pectins, adaptable bioactive plant polysaccharides with anti-inflammatory effects, supports osteoblast differentiation.
Kokkonen, H., Cassinelli, C., Verhoef, R., Morra, M., Schols, H.A., Tuukkanen, J.   +5 more
openaire   +2 more sources

Osteosarcoma and Osteoblastic Differentiation

Clinical Orthopaedics and Related Research, 2007
In addition to changes in cellular pathways, loss of differentiation is a notable feature of osteosarcoma. We hypothesized that blocks to normal differentiation may be a common feature of osteosarcoma, and may be one of many critical events that occur during oncogenesis in osteosarcoma.
Rex C, Haydon, Hue H, Luu, Tong-Chuan, He   +2 more
openaire   +2 more sources

The role of PPARγ for the osteoblastic differentiation.

Journal of endocrinological investigation, 2010
Peroxisome proliferator-activated receptor γ (PPARγ) is a ligand-activated transcription factor that belongs to the nuclear hormone receptor superfamily and functions as a heterodimer with a retinoid X receptor by binding to PPAR responsive elements. PPARγ plays an important role in adipocyte differentiation and is activated by long-chain fatty acid ...
Viccica, G, Francucci, C. M, MARCOCCI, CLAUDIO   +2 more
openaire   +3 more sources

Regulation of Runx2 by MicroRNAs in osteoblast differentiation

Life Sciences, 2019
Bone is one of the most dynamic organs in the body that continuously undergoes remodeling through bone formation and resorption. A cascade of molecules and pathways results in the osteoblast differentiation that is attributed to osteogenesis, or bone formation. The process of osteogenesis is achieved through participation of the Wnt pathway, FGFs, BMPs/
Akshaya, Narayanan, N, Srinaath, M, Rohini, N, Selvamurugan   +3 more
openaire   +2 more sources

Osteoblastic differentiation.

Ciba Foundation symposium, 1989
The fully differentiated osteoblast may be easily recognized in bone tissue. Its cuboidal shape, its position directly opposed to the bone surface and its capacity to produce calcified bone matrix are characteristic. Three other differentiation stages are also reasonably well defined--the preosteoblast, the osteocyte and the lining cell.
P J, Nijweide, A, van der Plas, A A, Olthof   +2 more
openaire   +1 more source

Osteoblasts: Differentiation and Function

1993
Cells of the osteoblast lineage occupy a central position in bone metabolism. The formation of a structurally sound skeleton, with its strength and integrity conserved by constant remodeling, and the formation as well as activation of the major bone-resorbing cell, the osteoclast, are the result of direct and indirect influences of osteoblasts.
T. J. Martin, D. M. Findlay, J. K. Heath, K. W. Ng   +3 more
openaire   +1 more source

Regulation of Osteoblast Differentiation by Runx2

2009
Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking ...
openaire   +2 more sources