Results 31 to 40 of about 65,828 (262)

Overexpression of hsa-miR-125b during osteoblastic differentiation does not influence levels of Runx2, osteopontin, and ALPL gene expression

Brazilian Journal of Medical and Biological Research, 2013
Multipotent mesenchymal stromal cells (MSCs) were first isolated from bone marrow and then from various adult tissues including placenta, cord blood, deciduous teeth, and amniotic fluid.
M.T. Pinto, L.D.F. Nicolete, E.S. Rodrigues, P.V.B. Palma, M.D. Orellana, S. Kashima, D.T. Covas   +6 more
doaj   +1 more source

Mesenchymal Stem Cell Spheroids Retain Osteogenic Phenotype Through α2β1 Signaling. [PDF]

, 2016
Unlabelled: The induction of mesenchymal stem cells (MSCs) toward the osteoblastic lineage using osteogenic supplements prior to implantation is one approach under examination to enhance their bone-forming potential.
Harvestine, Jenna N, Hoch, Allison I, Leach, J Kent, Murphy, Kaitlin C, Zhou, Dejie   +4 more
core   +1 more source

FOXO1 modulates osteoblast differentiation

Bone, 2011
Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to stimulation by bone morphogenetic proteins. Studies presented here examined the functional role of FOXO1 in a well defined culture system in which pre-osteoblastic cells undergo terminal differentiation in vitro. Mineralizing cultures of MC3T3-E1 cells were examined with or
Siqueira, Michelle F, Flowers, Stephen, Bhattacharya, Rupa, Faibish, Dan, Behl, Yugal, Kotton, Darrell N, Gerstenfeld, Lou, Moran, Elizabeth, Graves, Dana T   +8 more
openaire   +4 more sources

Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells

Stem Cell Research & Therapy, 2021
Background Transplantation of human bone marrow stromal cells (hBMSCs) is a promising therapy for bone regeneration due to their ability to differentiate into bone forming osteoblastic cells.
Justyna Magdalena Kowal, Sören Möller, Dalia Ali, Florence Figeac, Torben Barington, Hagen Schmal, Moustapha Kassem   +6 more
doaj   +1 more source

Hydraulic calcium silicate-based root canal sealers mitigate proinflammatory cytokine synthesis and promote osteogenesis in vitro

Journal of Dental Sciences, 2023
Background/purpose: The mineralized tissue-inductive ability and anti-inflammatory properties of hydraulic calcium silicate-based (HCSB) sealers have not been fully elucidated.
Aseel Alchawoosh, Kentaro Hashimoto, Nobuyuki Kawashima, Sonoko Noda, Kosuke Nozaki, Takashi Okiji   +5 more
doaj   +1 more source

Gastric carcinoma with osteoblastic differentiation

International Journal of Surgery Case Reports, 2012
Carcinosarcoma is a rare malignant biphasic tumor which has sarcomatous and carcinomatous components. Stomach localization is very rare. We discuss the diagnosis, follow-up and treatment of patients diagnosed with gastric carcinosarcoma in company with the literature review.A 73-year-old white male patient applied to hospital with dyspeptic complaints ...
Selcukbiricik, Fatih, Tural, Deniz, Senel, Elif Tuba, Dervisoglu, Sergülen, Serdengecti, Süheyla   +4 more
openaire   +2 more sources

TAp63γ and ΔNp63β promote osteoblastic differentiation of human mesenchymal stem cells: regulation by vitamin D3 Metabolites. [PDF]

PLoS ONE, 2015
The transcription factor p63 is required for skeletal formation, and is important for the regulation of 1α,25(OH)2D3 receptor (VDR) in human mesenchymal stem cells (hMSC).
Kevin M Curtis, Kristina K Aenlle, Rachel N Frisch, Guy A Howard   +3 more
doaj   +1 more source

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

IGFBP-2 Directly Stimulates Osteoblast Differentiation [PDF]

Journal of Bone and Mineral Research, 2014
ABSTRACT   Insulin-like growth factor binding protein 2 (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation.
Gang, Xi, Christine, Wai, Victoria, DeMambro, Clifford J, Rosen, David R, Clemmons   +4 more
openaire   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source