Results 81 to 90 of about 65,828 (262)

Bone Morphogenetic Protein/SMAD Signaling Orients Cell Fate Decision by Impairing KSRP-Dependent MicroRNA Maturation

Cell Reports, 2012
MicroRNAs (miRNAs) are essential regulators of development, physiology, and evolution, and their biogenesis is strictly controlled at multiple levels.
Michela Pasero, Matteo Giovarelli, Gabriele Bucci, Roberto Gherzi, Paola Briata   +4 more
doaj   +1 more source

Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. [PDF]

, 2012
Aging reduces the number of mesenchymal stem cells (MSCs) that can differentiate into osteoblasts in the bone marrow, which leads to impairment of osteogenesis.
Guan, Min, Jia, Junjing, Lam, Kit S, Lane, Nancy E, Liu, Ruiwu, Meng, Liping, Nolta, Jan, Panganiban, Brian, Ritchie, Robert O, Shahnazari, Mohammad, Yao, Wei, Zhou, Ping   +11 more
core   +1 more source

Bone: Osteoblastoma [PDF]

, 2010
Review on Bone: Osteoblastoma, with data on clinics, and the genes ...
de, Andrea CE, Hogendoorn, PCW
core   +1 more source

EBF2 Regulates Osteoblast-Dependent Differentiation of Osteoclasts [PDF]

Developmental Cell, 2005
Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a
KIESLINGER M, FOLBERTH S, DOBREVA G, DORN T, CROCI L, ERBEN R, CONSALEZ , GIAN GIACOMO, GROSSCHEDL R.   +7 more
openaire   +5 more sources

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

Current Topics in Pharmacological Research on Bone Metabolism: Promyelotic Leukemia Zinc Finger (PLZF) and Tumor Necrosis Factor-α-Stimulated Gene 6 (TSG-6) Identified by Gene Expression Analysis Play Roles in the Pathogenesis of Ossification of the Posterior Longitudinal Ligament

Journal of Pharmacological Sciences, 2006
.: To understand the molecular pathogenesis of ossification of the posterior longitudinal ligament of the spine (OPLL), an ectopic bone formation disease, we performed cDNA microarray analysis on cultured ligament cells from OPLL patients to understand ...
Ituro Inoue, Ryuji Ikeda, So Tsukahara
doaj   +1 more source

Role of transforming growth factor-β and extracellular regulated protein kinases in lipopolysaccharide-induced osteoblastic differentiation of porcine aortic valve interstitial cells

Di-san junyi daxue xuebao, 2020
Objective To investigate the role of transforming growth factor-β (TGF-β1) and extracellular regulated protein kinases (ERK) in lipopolysaccharide (LPS)-induced osteoblastic differentiation of porcine aortic valve interstitial cells (PVICs).
FENG Hao, SHI Qiong, JIANG Yingjiu
doaj   +1 more source

Activating the Osteoblastic USP26 Pathway Alleviates Multi‐Organ Fibrosis by Decreasing Insulin Resistance

Advanced Science, EarlyView.
The loss of Ubiquitin Specific Peptidase 26 (USP26) in osteoblasts results in decreased bone formation, as well as multi‐organ fibrosis associated with insulin resistance (IR). Mechanistically, the absence of USP26 reduces glycolysis and lactate accumulation, leading to decreased histone H3 lysine 18 lactylation (H3K18LA) in the promoter region of KH ...
Jiyuan Tang, Wenkai Ye, Liang He, Zhou Dan, Leilei Chang, Zijie You, Yuanyue Jiang, Guoqing Tang, Lianfu Deng, Changwei Li   +9 more
wiley   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

The biological properties of OGI surfaces positively act on osteogenic and angiogenic commitment of mesenchymal stem cells [PDF]

, 2017
Osteogenesis process displays a fundamental role during dental implant osteointegration. In the present work, we studied the influence of Osteon Growth Induction (OGI) surface properties on the angiogenic and osteogenic behaviors of ...
Bressan, Eriberto, Ferroni, Letizia, Gardin, Chiara, Ghensi, Paolo, Mandelli, Federico, Soldini, Claudio, Soldini, Maria Costanza, Zavan, Barbara   +7 more
core   +2 more sources