Results 111 to 120 of about 38,030 (279)

Dasatinib and quercetin prevent alveolar bone loss in aged mice

Journal of Periodontology, EarlyView.
Abstract Background Recent findings have associated alveolar bone loss (ABL) with the presence of senescent cells. Aging and the accumulation of senescent cells are associated with a pro‐inflammatory environment which may exacerbate tissue damage.
Luisa S. Battistelli, Renata M. Moraes, Yuri C. Santos, Jaqueline L. Ribeiro, Maíra T. Garcia, Renata F. Prado, Florent Elefteriou, Ana Lia Anbinder   +7 more
wiley   +1 more source

Role of Osteocytes in Myeloma Bone Disease: Anti-sclerostin Antibody as New Therapeutic Strategy

Frontiers in Immunology, 2018
Osteocytes are terminally differentiated cells of the osteoblast lineage. They are involved in the regulation of bone remodeling by increasing osteoclast formation or decreasing bone formation by the secretion of the osteoblast inhibitor sclerostin ...
Denise Toscani, Marina Bolzoni, Marzia Ferretti, Carla Palumbo, Nicola Giuliani   +4 more
doaj   +1 more source

Aging and periodontitis increase brain dissemination of oral bacteria

Journal of Periodontology, EarlyView.
Abstract Background The microbiome is a dynamic system that changes throughout life. Studies have revealed the relationship between periodontal disease and the oral microbiota; however, the impact of periodontal disease on the expression of senescence markers and on the inflammaging of the oral and systemic microbiome remains unclear.
Ozge Unlu, Tsute Chen, Nil Yakar, Zeliha Guney, Bruce Paster, Isabel Carreras, Alpaslan Dedeoglu, Alpdogan Kantarci   +7 more
wiley   +1 more source

Osteocytes and Bone Diseases [PDF]

, 2015
For many centuries, the osteoblast is considered to be responsible for bone formation. It is also believed that an imbalance of osteoblasts (weak) and osteoclasts (strong) is the main cause for bone diseases such as osteomalacia and osteoporosis and ...
Ren, Yinshi
core  

Orthodontic force stimulates eNOS and iNOS in rat osteocytes. [PDF]

, 2009
Contains fulltext : 81629.pdf (Publisher’s version ) (Open Access)Mechanosensitive osteocytes are essential for bone remodeling. Nitric oxide, an important regulator of bone remodeling, is produced by osteocytes through the activity of ...
Xie, R., Rheden, R.E.M. van, Von den Hoff, J.W., Bronckers, A.L., van Rheden, R.E., Tan, S.D., Bronckers, A.L.J.J., Hoff, J.W. Von den, Klein Nulend, J., Klein-Nulend, J., Kuijpers-Jagtman, A.M., Maltha, J.C.   +11 more
core   +1 more source

Autologous minimally manipulated adipose‐derived stromal vascular fraction in knee osteoarthritis: Lasting symptom relief and imaging evidence from a 12‐month prospective study

Knee Surgery, Sports Traumatology, Arthroscopy, EarlyView.
Abstract Purpose To evaluate the safety and efficacy of intra‐articular autologous transplantation of adipose‐derived connective tissue micrografts rich in stromal vascular fraction (CTM‐SVF), obtained using an enzyme‐free system (Hy‐Tissue® SVF) for knee osteoarthritis (OA). Methods Thirty patients (mean age of 53.3 ± 6.4 years) with Kellgren–Lawrence
Laura Mangiavini, Nicolò Rossi, Riccardo Giorgino, Francesco Borelli, Alessandra Colombini, Paola De Luca, Simona Landoni, Luca Maria Sconfienza, Carmelo Messina, Irene Beriotto, Giuseppe M. Peretti, Laura de Girolamo   +11 more
wiley   +1 more source

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Quasi-3D Cytoskeletal Dynamics of Osteocytes under Fluid Flow [PDF]

, 2010
Osteocytes respond to dynamic fluid shear loading by activating various biochemical pathways, mediating a dynamic process of bone formation and resorption.
Qiu J, Qiu, Jun, Bo Huo, Dong, Cheng, 霍波, Guo XE, Lu, X. Lucas, Huo B, X. Lucas Lu, Hillman EMC, Lu XL, Elizabeth M.C. Hillman, Jun Qiu, X. Edward Guo, Guo, X. Edward, Andrew D. Baik, Baik AD, Hillman, Elizabeth M.C., Huo, Bo, Cheng Dong, Baik, Andrew D., Dong C   +21 more
core   +1 more source

Fluorescent mapping of osteocyte-driven bone formation at pre-osteocyte and mature osteocyte lacunae

Acta Biomaterialia
Bone modeling and remodeling by osteoblasts and osteoclasts has been considered the primary mechanism of bone metabolism; however, osteocyte bone cells resorb their surrounding perilacunar bone matrix. It is unknown whether perilacunar remodeling contributes to bone formation in the absence of disease, disorder, or other external stimuli.
Sarah Ford, Kerstin Tiedemann, Rachel Shapiro, Svetlana V. Komarova, Katharina Jähn-Rickert, Elizabeth A. Zimmermann   +5 more
openaire   +2 more sources

AI‐Revealed Transition From Density‐ to Connectivity‐Controlled Mechanics in Hierarchical Porous Materials

Small, EarlyView.
Using synchrotron‐based multiscale imaging, generative modeling algorithms, and computational mechanics models, our study reveals a scale‐dependent transition in bone mechanics. The results of the power‐scaling law illustrate a transition from density‐controlled stiffness at the trabecular scale to connectivity‐controlled, porosity‐sensitive mechanics ...
Milad Masrouri, Federica Buccino, Laura Maria Vergani, Zhao Qin   +3 more
wiley   +1 more source