Results 51 to 60 of about 138,476 (311)
A perfusion culture system for assessing bone marrow stromal cell differentiation on PLGA scaffolds for bone repair [PDF]
, 2018 Biomaterials development for bone repair is currently hindered by the lack of physiologically relevant in vitro testing systems. Here we describe the novel use of a bi-directional perfusion bioreactor to support the long term culture of human bone marrow
Alini, Mauro +5 more
core +2 more sources
Frontiers in Endocrinology, 2021 The osteogenic differentiation capacity of senescent bone marrow mesenchymal stem cells (MSCs) is reduced. p53 not only regulates cellular senescence but also functions as a negative regulator in bone formation.
Chao Xia +5 more
doaj +1 more source
Mineralized Peptide Nanofiber Gels for Enhanced Osteogenic Differentiation [PDF]
ChemNanoMat, 2018 AbstractMineral deposition is observed in both bacterial and eukaryotic organisms through a broad range of mechanisms. Both organic and inorganic components play crucial roles in the formation of mineralized tissues, and acidic proteins are particularly important in this context owing to their ability to stimulate nucleation of minerals.
E. Deniz Eren +3 more
openaire +3 more sources
The Differentiation Balance of Bone Marrow Mesenchymal Stem Cells Is Crucial to Hematopoiesis. [PDF]
, 2018 Bone marrow mesenchymal stem cells (BMSCs), the important component and regulator of bone marrow microenvironment, give rise to hematopoietic-supporting stromal cells and form hematopoietic niches for hematopoietic stem cells (HSCs).
Li, Shengwen Calvin +6 more
core +2 more sources
Stem Cell Research & Therapy, 2020 Background Osteogenic differentiation of bone mesenchymal stem cells (BMSCs) is regulated by numerous signaling pathways. Dopamine (DA), a neurotransmitter, has previously been demonstrated to induce new bone formation by stimulating the receptors on ...
Chen-Xi Wang +5 more
doaj +1 more source
Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds. [PDF]
, 2019 The instructive capabilities of extracellular matrix-inspired materials for osteoprogenitor differentiation have sparked interest in understanding modulation of other cell types within the bone regenerative microenvironment.
Bischoff, David +11 more
core
Temperature responsiveness of gilthead sea bream bone; an in vitro and in vivo approach [PDF]
, 2018 This study aimed to characterize the molecules involved in osteogenesis in seabream and establish using in vitro/in vivo approaches the responsiveness of selected key genes to temperature.
Capilla, Encarnacion +8 more
core +3 more sources
Irisin enhances osteogenic differentiation of mouse MC3T3‑E1 cells via upregulating osteogenic genes
Experimental and Therapeutic Medicine, 2021 Osteoporosis affects millions of individuals and remains a clinical challenge in terms of prevention and treatment. The present study aimed to investigate the effect of irisin on osteogenic differentiation by exposing MC3T3-E1 cells to different concentrations of irisin.
Jian, Yang +5 more
openaire +3 more sources
Advanced Functional Materials, EarlyView.There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato +9 more
wiley +1 more source
Scientific ReportsUmbilical cord-derived human mesenchymal stem cells (UC-hMSCs) are multipotent stem cells with great potential for treating bone diseases. Although they can be easily isolated from umbilical cord tissue, their osteogenic differentiation is less efficient
Ladda Meesuk +4 more
doaj +1 more source