Results 51 to 60 of about 44,473 (251)

Development of Bone Targeting Drugs. [PDF]

, 2017
The skeletal system, comprising bones, ligaments, cartilage and their connective tissues, is critical for the structure and support of the body. Diseases that affect the skeletal system can be difficult to treat, mainly because of the avascular cartilage
Alméciga-Díaz, Carlos J., Mackenzie, William G., Mason, Robert W., Orii, Tadao, Sawamoto, Kazuki, Stapleton, Molly, Tomatsu, Shunji   +6 more
core   +2 more sources

Deciphering the Acetabular Labrum's Cellular Atlas: MDK Inhibition as a Novel Therapeutic Method for Developmental Dysplasia of the Hip

Advanced Science, EarlyView.
This study explores developmental dysplasia of the hip (DDH) by analyzing acetabular labrum abnormalities using single‐cell and spatial transcriptomics. Aberrant fibrocartilage stem cell proliferation is linked to DDH progression. Targeting the MK signaling pathway with a specific inhibitor effectively alleviates early DDH abnormalities, offering ...
Runze Yang, Huiling Liu, Minghao Ge, Dingyuan Zhang, Tianhao Xu, Lei Zhang, Yanlin Zhu, Shun Li, Jian Li, Xin Ma, Weili Fu   +10 more
wiley   +1 more source

Prophylaxis and antibiotic therapy in management protocols of patients treated with oral and intravenous bisphosphonates [PDF]

, 2017
Osteonecrosis of the jaw (MRONJ) linked to bisphosphonate treatment has specific characteristics that render its therapeutic management challenging for clinicians.
Bermúdez Bejarano, Elena Beatriz, Castillo de Oyagüe, Raquel, Gutiérrez Corrales, Aida, Gutiérrez Pérez, José Luis, Romero Ruiz, Manuel María, Serrera Figallo, María Angeles, Torres Lagares, Daniel   +6 more
core   +1 more source

Open and Closed Reduction for Developmental Dysplasia of the Hip in New York State: Incidence of Hip Reduction and Rates of Subsequent Surgery. [PDF]

, 2020
BackgroundThere are limited data on the incidence and outcomes of open and closed hip reduction in patients with developmental dysplasia of the hip (DDH).
Chang, Dodwell, Gholve, Gruel, Murray, Nelson, Novais, Pollet, Schoenecker, Shorter, Swarup, Upasani, Vitale, Weinstein, Zionts   +14 more
core   +1 more source

Development, Evaluation, and Characterization of a Novel Mucoadhesive Film Containing Pterodon pubescens Benth Ethanolic Extract for Dental Use

Journal of Applied Polymer Science, EarlyView.
Pterodon pubescens Mucoadhesive Film for dental use. ABSTRACT Periodontal diseases involve infectious and inflammatory processes that affect oral tissues. Extracts from Pterodon pubescens Benth (sucupira) have demonstrated antinociceptive, anti‐inflammatory, anti‐edematogenic, and antiplatelet effects, highlighting their therapeutic potential for ...
Mariana Cecchetto Figueiredo, Fabiana Volpe Zanutto, Akmal Sabri, Tuany Zambroti Cândido, Leila Servat Medina, Ilza Maria de Oliveira Sousa, Rosanna Tarkany Basting, Lucia Elaine de Oliveira Braga, Ellen Cristina Souza de Oliveira, Simone Nataly Busato de Feiria, Bruno da Fonseca‐Santos, Marlus Chorilli, Ramiro Mendonça Murata, Mary Ann Foglio   +13 more
wiley   +1 more source

Long-term radiographic and clinical-functional outcomes of isolated, displaced, closed talar neck and body fractures treated by ORIF: the timing of surgical management [PDF]

, 2019
Background: The main purpose of this retrospective case series study was to evaluate long-term radiographic and clinical outcomes of a consecutive series of patients diagnosed with isolated, displaced, closed talar neck or body fractures treated by open ...
Belluzzi, Elisa, Biz, Carlo, De Cicco, Michele, Fantoni, Ilaria, Frizziero, Antonio, Golin, Nicolo', Maschio, Nicola, Ruggieri, Pietro   +7 more
core   +1 more source

Expert Perspective: How, When, and Why to Potentially Stop Antiresorptive Drugs in Osteoporosis

Arthritis &Rheumatology, EarlyView.
Osteoporosis is a chronic disease, and antiresorptive treatments are often continued for many years. Despite their established efficacy in reducing fracture risk, the most commonly used antiresorptive treatments, bisphosphonates and denosumab, have short‐ and long‐term risks that, coupled with their benefits and other unique characteristics, influence ...
Giovanni Adami, Kenneth G. Saag
wiley   +1 more source

Utility of quantitative standardized uptake value from pre-operative bone SPECT/CT for predicting post-surgical MRONJ healing response

EJNMMI Research
Background Medication-related osteonecrosis of the jaw (MRONJ) is a challenging condition often associated with long-term use of anti-resorptive medications.
Jung-Hyun Park, Da-Mi Yoon, Hai-Jeon Yoon, Jin-Woo Kim   +3 more
doaj   +1 more source

Phase-contrast imaging with synchrotron hard X-ray reveals the effect of icariin on bone tissue morphology and microstructure in rabbits with early glucocorticoid-induced osteonecrosis of the femoral head

Frontiers in Cell and Developmental Biology, 2023
Background: Phase-contrast imaging (PCI) with synchrotron hard X-ray was used to observe the changes in bone tissue morphology and microstructure in rabbit models of early glucocorticoid-induced osteonecrosis of the femoral head (ONFH), and to evaluate ...
Xu Yang, Xu Yang, Lijun Shi, Aifeng Li, Fuqiang Gao, Wei Sun, Wei Sun, Zirong Li   +7 more
doaj   +1 more source

Which Osteotomy for Osteonecrosis of the Femoral Head and Which Patient for the Osteotomy? [PDF]

, 2019
Transtrochanteric curved varus osteotomy (TCVO) and transtrochanteric rotational osteotomy (TRO) are joint-preserving procedures for osteonecrosis of the femoral head.
Ha, Yong-Chan, Koo, Kyung-Hoi, Lee, Beomseok, Lee, Young-Kyun, Parvizi, Javad   +4 more
core   +1 more source