Results 1 to 10 of about 40,843 (302)

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their ...
Jing-Jing Wang, Wen Sun, Wei-Dong Jia, Ming Bian, Li-Jun Yu   +4 more
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Investigation of Novel Benzoxazole-Oxadiazole Derivatives as Effective Anti-Alzheimer’s Agents: In Vitro and In Silico Approaches

Pharmaceuticals, 2023
Alzheimer’s disease (AD) is a progressive neurological illness that is distinguished clinically by cognitive and memory decline and adversely affects the people of old age. The treatments for this disease gained much attention and have prompted increased
Saeed Anwar, Wajid Rehman, Rafaqat Hussain, Shoaib Khan, Mohammed M. Alanazi, Nawaf A. Alsaif, Yousaf Khan, Shahid Iqbal, Adeela Naz, Muhammad Ali Hashmi   +9 more
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Therapeutic potential of oxadiazole or furadiazole containing compounds

BMC Chemistry, 2020
As we know that, Oxadiazole or furadi azole ring containing derivatives are an important class of heterocyclic compounds. A heterocyclic five-membered ring that possesses two carbons, one oxygen atom, two nitrogen atoms, and two double bonds is known as ...
Ankit Siwach, Prabhakar Kumar Verma
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π–π Noncovalent Interaction Involving 1,2,4- and 1,3,4-Oxadiazole Systems: The Combined Experimental, Theoretical, and Database Study

Molecules, 2021
A series of N-pyridyl ureas bearing 1,2,4- (1a, 2a, and 3a) and 1,3,4-oxadiazole moiety (1b, 2b, 3b) was prepared and characterized by HRMS, 1H and 13C NMR spectroscopy, as well as X-ray diffraction.
Sergey V. Baykov, Alexander S. Mikherdov, Alexander S. Novikov, Kirill K. Geyl, Marina V. Tarasenko, Maxim A. Gureev, Vadim P. Boyarskiy   +6 more
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In vitro antitumor and immunomodulatory activities of 1,2,4-oxadiazole derivatives [PDF]

Biochemistry and Biophysics Reports
Melanoma is the most aggressive and lethal type of skin cancer, responsible for approximately 60,000 deaths annually. The main strategy for treating melanoma is surgery to completely remove the lesion and its margins.
Héverton Mendes Araújo, Gabriel Acácio de Moura, Yasmim Mendes Rocha, Cristian Vicson Pinheiro Gomes, Valentina Nascimento e Melo de Oliveira, Ronaldo Nascimento de Oliveira, Larissa Deadame de Figueiredo Nicolete, Emanuel Paula Magalhães, Ramon R.P.P.B. de Menezes, Roberto Nicolete   +9 more
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A survey of liquid crystalline oxadiazoles [PDF]

ChemInform, 2008
We propose a survey of those oxadiazole compounds, which are mesogenic. We will see that they can have bend-shaped molecules, a biaxial nematic phase, or other interesting peculiarities in the nematic and smectic phase.
Sparavigna, Amelia
core   +4 more sources

Transition metal complexes with a new tridentate ligand, 5-[6-(5-mercapto- 1,3,4-oxadiazol-2-yl)pyridin-2-yl]-1,3,4-oxadiazole-2-thiol [PDF]

Journal of the Serbian Chemical Society, 2007
A new ligand 5-[6-(5-mercapto-1,3,4-oxadiazol-2-yl)pyridin-2-yl]-1,3,4-oxadiazole- 2-thiol (L) and its Mn(II), Co(II), Ni(II), Cu(II), and Zn(II) complexes were synthesized.
Gudasi Kalagouda, Patil Manjula, Vadavi Ramesh, Shenoy Rashmi, Patil Siddappa   +4 more
doaj   +5 more sources

Green Synthetic Approach: An Efficient Eco-Friendly Tool for Synthesis of Biologically Active Oxadiazole Derivatives

Molecules, 2021
Green synthetic protocol refers to the development of processes for the sustainable production of chemicals and materials. For the synthesis of various biologically active compounds, energy-efficient and environmentally benign processes are applied, such
Bimal Krishna Banik, Biswa Mohan Sahoo, Bera Venkata Varaha Ravi Kumar, Krishna Chandra Panda, Jasma Jena, Manoj Kumar Mahapatra, Preetismita Borah   +6 more
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Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery

Pharmaceuticals, 2020
Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities.
Karol Biernacki, Mateusz Daśko, Olga Ciupak, Konrad Kubiński, Janusz Rachon, Sebastian Demkowicz   +5 more
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Photophysical characterizations of 2-(4-Biphenylyl)-5 phenyl-1,3,4- oxadiazole in restricted geometry [PDF]

, 2008
Langmuir and Langmuir-Blodgett (LB) films of nonamphiphilic 2-(4-Biphenylyl)-5 phenyl-1,3,4- oxadiazole (abbreviated as PBD) mixed with stearic acid (SA) as well as also with the inert polymer matrix poly(methyl methacrylate) (PMMA) have been studied ...
Acharya, Acharya, Adachi, Araca, Brinkhuis, Capan, Capan, D. Bhattacharjee, Deb, Dutta, Dutta, Franco, Hamada, Heimel, Hughles, Hussain, Hussain, Hussain, Jordanov, Kasha, Kasha, Kawamata, Kramarenko, Kuhn, Maliszewskyj, Matsais, McRae, P.K. Paul, Pal, Petty, Prasad, Puschig, Robarts, S.A. Hussain, Shen, Stumpe, Szatmari, Torgova, Ulman, Viswanath, Wihmershaus, Yeom   +41 more
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