Results 1 to 10 of about 13,309 (78)

Investigation of Novel Benzoxazole-Oxadiazole Derivatives as Effective Anti-Alzheimer’s Agents: In Vitro and In Silico Approaches

Pharmaceuticals, 2023
Alzheimer’s disease (AD) is a progressive neurological illness that is distinguished clinically by cognitive and memory decline and adversely affects the people of old age. The treatments for this disease gained much attention and have prompted increased
S. Anwar, W. Rehman, R. Hussain, Shoaib Khan, M. Alanazi, Nawaf A. Alsaif, Yousaf Khan, S. Iqbal, Adeela Naz, Muhammad Ali Hashmi   +9 more
semanticscholar   +1 more source

An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors

Pharmaceuticals, 2023
The world’s health system is plagued by cancer and a worldwide effort is underway to find new drugs to treat cancer. There has been a significant improvement in understanding the pathogenesis of cancer, but it remains one of the leading causes of death ...
Davinder Kumar, Navidha Aggarwal, A. Deep, H. Kumar, Hitesh Chopra, R. K. Marwaha, S. Cavalu   +6 more
semanticscholar   +1 more source

Biological activity of oxadiazole and thiadiazole derivatives

Applied Microbiology and Biotechnology, 2022
The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-known heterocycles, being a common and essential feature of a variety of natural products and medicinal agents.
Upare Abhay Atmaram, S. Roopan
semanticscholar   +1 more source

Research progress on the synthesis and pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole derivatives: a mini review

Journal of Enzyme Inhibition and Medicinal Chemistry, 2022
Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their ...
Jing-Jing Wang, Wen-zhou Sun, Wei-Dong Jia, M. Bian, Lijun Yu   +4 more
semanticscholar   +1 more source

Ultrasonic-Assisted Synthesis of Benzofuran Appended Oxadiazole Molecules as Tyrosinase Inhibitors: Mechanistic Approach through Enzyme Inhibition, Molecular Docking, Chemoinformatics, ADMET and Drug-Likeness Studies

International Journal of Molecular Sciences, 2022
Furan-oxadiazole structural hybrids belong to the most promising and biologically active classes of oxygen and nitrogen containing five member heterocycles which have expanded therapeutic scope and potential in the fields of pharmacology, medicinal ...
Ali Irfan, A. F. Zahoor, S. Kamal, Mubashir Hassan, A. Kloczkowski   +4 more
semanticscholar   +1 more source

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives

International Journal of Molecular Sciences, 2021
The worldwide development of antimicrobial resistance forces scientists to search for new compounds to which microbes would be sensitive. Many new structures contain the 1,3,4-oxadiazole ring, which have shown various antimicrobial activity, e.g ...
T. Glomb, P. Świątek
semanticscholar   +1 more source

π–π Noncovalent Interaction Involving 1,2,4- and 1,3,4-Oxadiazole Systems: The Combined Experimental, Theoretical, and Database Study

Molecules, 2021
A series of N-pyridyl ureas bearing 1,2,4- (1a, 2a, and 3a) and 1,3,4-oxadiazole moiety (1b, 2b, 3b) was prepared and characterized by HRMS, 1H and 13C NMR spectroscopy, as well as X-ray diffraction.
S. Baykov, A. Mikherdov, A. Novikov, Kirill Geyl, M. Tarasenko, M. A. Gureev, V. Boyarskiy   +6 more
semanticscholar   +1 more source

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives

Pharmaceuticals, 2021
In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized.
C. Stecoza, G. Nițulescu, C. Draghici, M. Cǎproiu, O. T. Olaru, M. Bostan, M. Mihaila   +6 more
semanticscholar   +1 more source

Synthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents

Pharmaceuticals, 2021
A library of 1,2,3-triazole-incorporated thymol-1,3,4-oxadiazole derivatives (6–18) hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8, 9, 10, and 11 exhibited significant antiproliferative activity.
Abdulraheem S. A. Almalki, Syed Nazreen, A. Malebari, N. Ali, A. Elhenawy, Abdullah A. A. Alghamdi, Abrar Ahmad, S. Y. Alfaifi, M. Alsharif, Mohammad Mahboob Alam   +9 more
semanticscholar   +1 more source

Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery

Pharmaceuticals, 2020
Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities.
Karol Biernacki, Mateusz Daśko, Olga Ciupak, K. Kubiński, J. Rachon, Sebastian Demkowicz   +5 more
semanticscholar   +1 more source