Results 11 to 20 of about 40,843 (302)
The Role of Five-Membered Aromatic Rings Containing N and O in Modulating Bile Acid Receptors: An Overview. [PDF]
ChemMedChemSeveral derivatives incorporating five‐membered aromatic rings are described in this review as bile acid receptor modulators, particularly targeting the farnesoid X receptor and the G protein‐coupled bile acid receptor 1. This review provides a comprehensive analysis of patents and literature that is useful to support researchers in the design of new ...
Finamore C +5 more
europepmc +2 more sources
RSC Advances, 2023 In this study, twenty eight novel oxadiazole derivatives (5–32) of the marketed available non-steroidal anti-inflammatory drug (NSAID), (S)-flurbiprofen (1), were synthesized via I2 mediated cyclo-addition reaction in better yields.
Sajjad Ahmad +9 more
semanticscholar +1 more source
Pharmaceuticals, 2023 Human tyrosinase (hTYR) is a key and rate-limiting enzyme along with human tyrosinase-related protein-1 (hTYRP1), which are among the most prominent targets of inhibiting hyper pigmentation and melanoma skin cancer.
Ali Irfan +7 more
semanticscholar +1 more source
Pharmaceuticals, 2023 The world’s health system is plagued by cancer and a worldwide effort is underway to find new drugs to treat cancer. There has been a significant improvement in understanding the pathogenesis of cancer, but it remains one of the leading causes of death ...
Davinder Kumar +6 more
semanticscholar +1 more source
Biological activity of oxadiazole and thiadiazole derivatives
Applied Microbiology and Biotechnology, 2022 The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-known heterocycles, being a common and essential feature of a variety of natural products and medicinal agents.
Upare Abhay Atmaram, S. Roopan
semanticscholar +1 more source
Journal of Applied Pharmaceutical Research, 2022 A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial ...
Shivanand Kolageri +2 more
doaj +1 more source
The oxadiazole antibacterials [PDF]
Current Opinion in Microbiology, 2016 The oxadiazoles are a class of antibacterials discovered by in silico docking and scoring of compounds against the X-ray structure of a penicillin-binding protein. These antibacterials exhibit activity against Gram-positive bacteria, including against methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE).
Shahriar Mobashery +2 more
openaire +3 more sources
A Review of Modern Methods of Synthesis 1, 3, 4-Oxadiazole as a Bioactive Compounds
Wasit Journal for Pure Sciences, 2023 : Oxadiazole ring is a heterocyclic molecule with an oxygen and two nitrogen atoms spread throughout its five-membered structure. There are four different isomers that have been discovered, Because of their wide applications in a range of sectors ...
hajar adeeb
doaj +1 more source
Journal of Enzyme Inhibition and Medicinal Chemistry, 2022 Sulphonamide and 1,3,4-oxadiazole moieties are present as integral structural parts of many drugs and pharmaceuticals. Taking into account the significance of these moieties, we herein present the synthesis, single-crystal X-ray analysis, DFT studies ...
B. Khan +7 more
semanticscholar +1 more source
Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives
International Journal of Molecular Sciences, 2021 The worldwide development of antimicrobial resistance forces scientists to search for new compounds to which microbes would be sensitive. Many new structures contain the 1,3,4-oxadiazole ring, which have shown various antimicrobial activity, e.g ...
T. Glomb, P. Świątek
semanticscholar +1 more source