Results 11 to 20 of about 41,732 (296)

Activity Profiling of Nitro-Substituted Di(Hetero)Aryl 1,3,4- and 1,2,4-Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential. [PDF]

Arch Pharm (Weinheim)
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Šikorová E, Štěpánková Š, Frýbová E, Konečná K, Korbielová J, Švarcová M, Janďourek O, Pflégr V, Bősze S, Krátký M.   +9 more
europepmc   +2 more sources

Design, synthesis, structural characterization, and antioxidant potential of novel triazole- and oxadiazole-based hydrazide-hydrazone derivatives: spectroscopic, DFT, and molecular docking studies. [PDF]

BMC Chem
Abdo MA, Badawy SA, Fadda AA, Elmorsy MR.   +3 more
europepmc   +2 more sources

Biological activity of oxadiazole and thiadiazole derivatives

Applied Microbiology and Biotechnology, 2022
The 5-membered oxadiazole and thiadiazole scaffolds are the most privileged and well-known heterocycles, being a common and essential feature of a variety of natural products and medicinal agents.
Upare Abhay Atmaram, S. Roopan
semanticscholar   +1 more source

Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design. [PDF]

Angew Chem Int Ed Engl
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK.   +6 more
europepmc   +3 more sources

Structure-Based Virtual Screening of Furan-1,3,4-Oxadiazole Tethered N-phenylacetamide Derivatives as Novel Class of hTYR and hTYRP1 Inhibitors

Pharmaceuticals, 2023
Human tyrosinase (hTYR) is a key and rate-limiting enzyme along with human tyrosinase-related protein-1 (hTYRP1), which are among the most prominent targets of inhibiting hyper pigmentation and melanoma skin cancer.
Ali Irfan, Shah Faisal, Sajjad Ahmad, S. Al-Hussain, Sadia Javed, A. F. Zahoor, Bushra Parveen, M. Zaki   +7 more
semanticscholar   +1 more source

Novel flurbiprofen clubbed oxadiazole derivatives as potential urease inhibitors and their molecular docking study

RSC Advances, 2023
In this study, twenty eight novel oxadiazole derivatives (5–32) of the marketed available non-steroidal anti-inflammatory drug (NSAID), (S)-flurbiprofen (1), were synthesized via I2 mediated cyclo-addition reaction in better yields.
Sajjad Ahmad, Momin Khan, Aftab Alam, Amar Ajmal, A. Wadood, Azim. Khan, A. Alasmari, M. Alharbi, Abdulrahman Alshammari, Abdul Shakoor   +9 more
semanticscholar   +1 more source

An Understanding of Mechanism-Based Approaches for 1,3,4-Oxadiazole Scaffolds as Cytotoxic Agents and Enzyme Inhibitors

Pharmaceuticals, 2023
The world’s health system is plagued by cancer and a worldwide effort is underway to find new drugs to treat cancer. There has been a significant improvement in understanding the pathogenesis of cancer, but it remains one of the leading causes of death ...
Davinder Kumar, Navidha Aggarwal, A. Deep, H. Kumar, Hitesh Chopra, R. K. Marwaha, S. Cavalu   +6 more
semanticscholar   +1 more source

In-silico ADME prediction and molecular docking study of novel benzimidazole-1,3,4-oxadiazole derivatives as CYP51 inhibitors for antimicrobial activity

Journal of Applied Pharmaceutical Research, 2022
A class of innovative benzimidazole-1,3,4-Oxadiazole derivatives is a significant heterocyclic molecule for therapeutic development. In heterocyclic chemistry, the novel 1,3,4-Oxadiazole nucleus has a wide range of uses, including antibacterial ...
Shivanand Kolageri, S Hemanth, Mahesh Parit   +2 more
doaj   +1 more source

Antimicrobial Activity of 1,3,4-Oxadiazole Derivatives

International Journal of Molecular Sciences, 2021
The worldwide development of antimicrobial resistance forces scientists to search for new compounds to which microbes would be sensitive. Many new structures contain the 1,3,4-oxadiazole ring, which have shown various antimicrobial activity, e.g ...
T. Glomb, P. Świątek
semanticscholar   +1 more source

A Review of Modern Methods of Synthesis 1, 3, 4-Oxadiazole as a Bioactive Compounds

Wasit Journal for Pure Sciences, 2023
: Oxadiazole ring is a heterocyclic molecule with an oxygen and two nitrogen atoms spread throughout its five-membered structure. There are four different isomers that have been discovered, Because of their wide applications in a range of sectors ...
hajar adeeb
doaj   +1 more source