Results 21 to 30 of about 13,309 (78)

Domain Walls and Anchoring Transitions Mimicking Nematic Biaxiality in the Oxadiazole Bent-Core Liquid Crystal C7 [PDF]

, 2015
We investigate the origin of secondary disclinations that were recently described as a new evidence of a biaxial nematic phase in an oxadiazole bent-core thermotropic liquid crystal C7. With an assortment of optical techniques such as polarizing optical microscopy, LC PolScope, and fluorescence confocal polarizing microscopy, we demonstrate that the ...
arxiv   +1 more source

Phototherapy via Modulation of β‐Amyloid in Combating Alzheimer's Disease

Aggregate, EarlyView.
This review introduces the light‐regulated Aβ aggregation, highlighting four applications: photodynamic therapy (PDT), photothermal therapy (PTT), photopharmacology, and photobiomodulation (PBM) systems. It also summarizes the current issues and proposes the prospects of photo‐induced modulation of Aβ aggregation and clearance as a therapeutic strategy
Yunhua Zhang, Chengyuan Qian, Yuncong Chen, Weijiang He, Zijian Guo   +4 more
wiley   +1 more source

Groundbreaking Anticancer Activity of Highly Diversified Oxadiazole Scaffolds

International Journal of Molecular Sciences, 2020
Nowadays, an increasing number of heterocyclic-based drugs found application in medicinal chemistry and, in particular, as anticancer agents. In this context, oxadiazoles—five-membered aromatic rings—emerged for their interesting biological properties ...
A. Benassi, F. Doria, Valentina Pirota
semanticscholar   +1 more source

Spatiotemporal Super‐Resolution Imaging of Lipid Metabolism Dynamics in Physiological/Pathological Conditions

Angewandte Chemie International Edition, Accepted Article.
Dysregulated lipid metabolism plays a critical role in the pathogenesis of numerous diseases. However, due to the lack of effective solutions, the dynamic monitoring and deep understanding of lipid metabolism in the progression of diseases has remained challenging.
Shixian Cao, Qihang Ding, Caixia Sun, Borbala Codogno, Zhiqiang Liu, Xiaoqiang Yu, Jong Seung Kim, Kang-Nan Wang   +7 more
wiley   +1 more source

Functional Polymers for Silicon Anodes from Liquid to Solid Electrolyte Batteries

Batteries &Supercaps, EarlyView.
Silicon, despite its high capacity as a promising anode material for lithium‐ion batteries, encounters challenges of volume expansion and unstable solid electrolyte interphase. Polymers serve as binders, modifiers, and electrolytes to address these issues, with this review outlining their roles and suggesting future research directions. Due to its high
Xiuxia Zuo, Felix H. Richter
wiley   +1 more source

Advances in Mechanochemical Methods for One‐Pot Multistep Organic Synthesis

Chemistry – A European Journal, Accepted Article.
Mechanochemical synthesis has emerged as a powerful and more sustainable alternative to conventional solution‐based methods, offering advantages such as no or only minimal solvent use, reduced reaction times, and simplified operational conditions.
Michael Schnürch, Nina Biedermann
wiley   +1 more source

β‐Lactam Ylidenes: An Overlooked Class of N‐Heterocyclic Carbenes

Chemistry – A European Journal, EarlyView.
A highly modular synthetic approach toward four‐membered β‐lactam carbenes (BLCs) is presented. BLCs feature moderate σ‐donor and strong π‐acceptor character, leading to a pronounced ambiphilic reactivity which includes the formation of olefinic dimers as well as unprecedented N2‐bridged dimers, oxirane formation with acetone, and fragmentation to ...
Leonard Karl, Daniel Deißenbeck, Jan Meisner, Christian Ganter   +3 more
wiley   +1 more source

Synthesis, Antimycobacterial Activity and Computational Insight of novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates Against Multidrug‐Resistant M. tuberculosis

ChemMedChem, Accepted Article.
To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri, Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukic   +6 more
wiley   +1 more source

Deferasirox Derivatives as Inhibitors of Kallikrein‐Related Peptidases Associated to Neurodegenerative Diseases

ChemMedChem, EarlyView.
Dysregulated proteolysis mediated by kallikrein‐related peptidases (KLKs) and iron overload are involved in the progression of neurodegenerative diseases. Deferasirox, an clinically‐approved iron chelator, and its newly synthesized derivatives have been identified as inhibitors of major central nervous system KLKs with low cytotoxicity and effective ...
Rilès Boumali, Elodie David, Nancy Chaaya, Morane Lucas, Sabrina Aït Amiri, Valérie Lefort, Anthony Nina‐Diogo, Michèle Salmain, Isabelle Petropoulos, Vincent Corcé, Chahrazade El Amri, Candice Botuha   +11 more
wiley   +1 more source

Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents.

Journal of Agricultural and Food Chemistry, 2018
This study aimed to synthesize some new sulfone derivatives containing a 1,3,4-oxadiazole moiety and investigate their in vitro antibacterial activities against Xanthomonas oryzae pv. oryzae ( Xoo) and Xanthomonas axonopodis pv.
Pei Li, D. Hu, D. Xie, Jixiang Chen, Linhong Jin, B. Song   +5 more
semanticscholar   +1 more source