Results 31 to 40 of about 41,732 (296)

Design and Activity of Novel Oxadiazole Based Compounds That Target Poly(ADP-ribose) Polymerase

Molecules, 2022
Novel PARP inhibitors with selective mode-of-action have been approved for clinical use. Herein, oxadiazole based ligands that are predicted to target PARP-1 have been synthesized and screened for the loss of cell viability in mammary carcinoma cells ...
Divakar Vishwanath, Swamy S. Girimanchanaika, Dukanya Dukanya, Shobith Rangappa, Ji-Rui Yang, Vijay Pandey, Peter E. Lobie, Basappa Basappa   +7 more
doaj   +1 more source

Novel 1,2,4-Oxadiazole Derivatives in Drug Discovery

Pharmaceuticals, 2020
Five-membered 1,2,4-oxadiazole heterocyclic ring has received considerable attention because of its unique bioisosteric properties and an unusually wide spectrum of biological activities.
Karol Biernacki, Mateusz Daśko, Olga Ciupak, K. Kubiński, J. Rachon, Sebastian Demkowicz   +5 more
semanticscholar   +1 more source

Green Chemistry Synthesis of Five-Membered Heterocylic Derivatives (1, 3, 4-oxadizoles) by Using Grinding Technique [PDF]

Kirkuk Journal of Science, 2018
In this research we prepared about 28 derivatives of five-membered heterocyclic compounds (1,3,4-oxadizoles) in two lines , in the first line we used phenylhydrazide and in the second line we used 4-hydroxy phenylhydrazide as starting material for ...
Nihad Taha, Eehab Rasheed
doaj   +1 more source

Bioactive Oxadiazoles 2.0

International Journal of Molecular Sciences, 2022
Oxadiazoles are electron-poor, five-membered aromatic heterocycles that contain one oxygen and two nitrogen atoms [...]
openaire   +2 more sources

N-Phenyl-N-{4-[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl}aniline

Acta Crystallographica Section E, 2008
The title compound, C25H18N4O, is a non-planar bipolar ligand containing triphenylamine and 1,3,4-oxadiazole units. In the molecule, the benzene ring, the 1,3,4-oxadiazole ring, and the pyridine ring are twisted slightly with respect to each other ...
Li-Ping Han, Bin Li, Jie Liu
doaj   +1 more source

Synthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents

Pharmaceuticals, 2021
A library of 1,2,3-triazole-incorporated thymol-1,3,4-oxadiazole derivatives (6–18) hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8, 9, 10, and 11 exhibited significant antiproliferative activity.
Abdulraheem S. A. Almalki, Syed Nazreen, A. Malebari, N. Ali, A. Elhenawy, Abdullah A. A. Alghamdi, Abrar Ahmad, S. Y. Alfaifi, M. Alsharif, Mohammad Mahboob Alam   +9 more
semanticscholar   +1 more source

Synthesis and Anticancer Evaluation of New 1,3,4-Oxadiazole Derivatives

Pharmaceuticals, 2021
In order to develop novel chemotherapeutic agents with potent anticancer activities, a series of new 2,5-diaryl/heteroaryl-1,3,4-oxadiazoles were designed and synthesized.
C. Stecoza, G. Nițulescu, C. Draghici, M. Cǎproiu, O. T. Olaru, M. Bostan, M. Mihăilă   +6 more
semanticscholar   +1 more source

In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics.
P. Deb, N. Al-Shar’i, Katharigatta N. Venugopala, M. Pillay, Pobitra Borah   +4 more
semanticscholar   +1 more source

Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery

Inorganics, 2022
Metal mediated coupling of isocyanides with substituted N-(pyridine-2-yl) ureas was first used to incorporate privileged biological motifs into platinum metal complexes.
Kirill K. Geyl, Svetlana O. Baykova, Pavel A. Andoskin, Vladimir V. Sharoyko, Anastasiya A. Eliseeva, Sergey V. Baykov, Konstantin N. Semenov, Vadim P. Boyarskiy   +7 more
doaj   +1 more source

SYNTHESIS,ANTIBACTERIAL ACTIVITY OF 2-AMINO 5-PHENYL -1,3,4- OXADIAZOLE DERIVATIVES

مجلة بغداد للعلوم, 2008
In the present investigation, five derivatives were synthesized as potential  antimicrobial   agents , The compounds  are : 2-amino 5-phenyl - 1,3,4-  oxadiazole  dithi-ocarbomate, 2-amino 5-( 4-amino- N,N-dimethyl phenyl)-  1,3,4- oxadiazole,    2 ...
Hussain jassem Mohammed
doaj   +1 more source