Results 31 to 40 of about 40,843 (302)

N-Phenyl-N-{4-[5-(4-pyridyl)-1,3,4-oxadiazol-2-yl]phenyl}aniline

Acta Crystallographica Section E, 2008
The title compound, C25H18N4O, is a non-planar bipolar ligand containing triphenylamine and 1,3,4-oxadiazole units. In the molecule, the benzene ring, the 1,3,4-oxadiazole ring, and the pyridine ring are twisted slightly with respect to each other ...
Li-Ping Han, Bin Li, Jie Liu
doaj   +1 more source

Synthesis and Biological Evaluation of 1,2,3-Triazole Tethered Thymol-1,3,4-Oxadiazole Derivatives as Anticancer and Antimicrobial Agents

Pharmaceuticals, 2021
A library of 1,2,3-triazole-incorporated thymol-1,3,4-oxadiazole derivatives (6–18) hasbeen synthesized and tested for anticancer and antimicrobial activities. Compounds 7, 8, 9, 10, and 11 exhibited significant antiproliferative activity.
Abdulraheem S. A. Almalki, Syed Nazreen, A. Malebari, N. Ali, A. Elhenawy, Abdullah A. A. Alghamdi, Abrar Ahmad, S. Y. Alfaifi, M. Alsharif, Mohammad Mahboob Alam   +9 more
semanticscholar   +1 more source

Bioactive Oxadiazoles 2.0

International Journal of Molecular Sciences, 2022
Oxadiazoles are electron-poor, five-membered aromatic heterocycles that contain one oxygen and two nitrogen atoms [...]
openaire   +2 more sources

4-[4-(4-Amino-1,2,5-oxadiazol-3-yl)-1,2,5-oxadiazol-3-yl]-1,2,5-oxadiazol-3-amine [PDF]

Acta Crystallographica Section E Structure Reports Online, 2012
The complete molecule of the compound, C(6)H(4)N(8)O(3), is generated by a crystallographic twofold rotation axis that runs through the central ring. The flanking ring is twisted by 20.2 (1)° with respect to the central ring. One of the amino H atoms forms an intra-molecular N-H⋯N hydrogen bond; adjacent mol-ecules are linked by N-H⋯N hydrogen bonds ...
Seik Weng Ng, Seik Weng Ng, Bo-Zhou Wang, Si-Yuan Jia, Xuezhong Fan, Ping Li   +5 more
openaire   +4 more sources

In vitro anti-TB properties, in silico target validation, molecular docking and dynamics studies of substituted 1,2,4-oxadiazole analogues against Mycobacterium tuberculosis

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
The alarming increase in multi- and extensively drug-resistant (MDR and XDR) strains of Mycobacterium tuberculosis (MTB) has triggered the scientific community to search for novel, effective, and safer therapeutics.
P. Deb, N. Al-Shar’i, Katharigatta N. Venugopala, M. Pillay, Pobitra Borah   +4 more
semanticscholar   +1 more source

Palladium(II) and Platinum(II) Deprotonated Diaminocarbene Complexes Based on N-(2-Pyridyl)ureas with Oxadiazole Periphery

Inorganics, 2022
Metal mediated coupling of isocyanides with substituted N-(pyridine-2-yl) ureas was first used to incorporate privileged biological motifs into platinum metal complexes.
Kirill K. Geyl, Svetlana O. Baykova, Pavel A. Andoskin, Vladimir V. Sharoyko, Anastasiya A. Eliseeva, Sergey V. Baykov, Konstantin N. Semenov, Vadim P. Boyarskiy   +7 more
doaj   +1 more source

Thermal behavior of polytriazole films: a thermal analysis study [PDF]

, 1989
The thermal behavior of poly(1,3-phenyl-1,4-phenyl)-4-phenyl-1,2,4-triazole has been investigated using different scanning calorimetry (DSC) and thermogravimetry (TG).
Gebben, B., Mulder, M.H.V., Smolders, C.A.   +2 more
core   +2 more sources

SYNTHESIS,ANTIBACTERIAL ACTIVITY OF 2-AMINO 5-PHENYL -1,3,4- OXADIAZOLE DERIVATIVES

مجلة بغداد للعلوم, 2008
In the present investigation, five derivatives were synthesized as potential  antimicrobial   agents , The compounds  are : 2-amino 5-phenyl - 1,3,4-  oxadiazole  dithi-ocarbomate, 2-amino 5-( 4-amino- N,N-dimethyl phenyl)-  1,3,4- oxadiazole,    2 ...
Hussain jassem Mohammed
doaj   +1 more source

1,3,4-Oxadiazole N-Mannich Bases: Synthesis, Antimicrobial, and Anti-Proliferative Activities

Molecules, 2021
The reaction of 5-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole-2(3H)-thione 3 with formaldehyde solution and primary aromatic amines or 1-substituted piperazines, in ethanol at room temperature yielded the corresponding N-Mannich bases 3-arylaminomethyl-5-(3,4-
L. Al-Wahaibi, A. A. Mohamed, Samar S. Tawfik, H. M. Hassan, A. El-Emam   +4 more
semanticscholar   +1 more source

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +1 more source