Results 61 to 70 of about 40,843 (302)

Synthesis, In Silico, and Biological Evaluation of Non‐Hydroxamate Benzoic Acid–Based Derivatives as Potential Histone Deacetylase Inhibitors (HDACi)

Chemistry &Biodiversity, EarlyView.
Compound A3bn exhibited strong binding affinities for HDAC2, HDAC6, and HDAC8. A3bn’s anticancer IC50 values were similar to those of SAHA. Cell death resulted from the extrinsic apoptotic pathway. Compound A3bn, a hydrophilic linker, which promotes zinc coordination, may be the cause of its increased activity across HDAC isoforms. ABSTRACT Unregulated
Nedaa A. Abd Al Rahim, Ammar A. Razzak Mahmood, Lubna H. Tahtamouni, Randa M. Bawadi, Ayah Y. Almasri, Marya A. Hamad, Nour A. Hussein, Salem R. Yasin, Abdulrahman M. Saleh   +8 more
wiley   +1 more source

Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

Molecules, 2014
The carbohydrazide 1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole 7, [1,3,4]oxadiazolo[2,3-a]isoindole 10b and pyrazole units 18. On the other hand, the thiosemicarbazone 20 was used as
Mohamed M. El Sadek, Nagwa S. Abd El-Dayem, Seham Y. Hassan, Mohamed A. Mostafa, Galila A. Yacout   +4 more
doaj   +1 more source

(1-(4-(5-Phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-Bisfunctionalized 3- and 4-PEG: Synthesis and Photophysical Studies

Molecules, 2023
Two new azaheterocycle-based bolas, such as (1-(4-(5-phenyl-1,3,4-oxadiazol-2-yl)phenyl)-1H-1,2,3-triazol-4-yl)-methylenyls α,ω-bisfunctionalized PEGs, were prepared via Cu-catalyzed click reaction between 2-(4-azidophenyl)-5-(aryl)-oxadiazole-1,3,4 and ...
Mohammed S. Mohammed, Igor S. Kovalev, Natalya V. Slovesnova, Leila K. Sadieva, Vadim A. Platonov, Grigory A. Kim, Rammohan Aluru, Alexander S. Novikov, Olga S. Taniya, Valery N. Charushin   +9 more
doaj   +1 more source

Study on the synthesis of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles and their acid–base interactions [PDF]

, 2014
: A series of novel 5-substituted 2-[2-(pyridyl)ethenyl]-1,3,4-oxadiazoles were efficiently synthesized by cyclocondensation of the appropriate 3-(pyridyl)acrylohydrazides with triethyl orthoesters in the presence of glacial acetic acid.
Agnieszka Kudelko, Karolina Jasiak, Krzysztof Ejsmont   +2 more
core   +1 more source

Recovery of Liquid Organic Radioactive Waste Absorbed Into Soil by Extraction

CleanMat, EarlyView.
Radioactive organic liquid waste adsorbed in soil containing pure beta‐emitting radionuclides such as H‐3 must be radiologically characterized for subsequent management. For this purpose, a method for the recovery of radioactive scintillation liquids adsorbed in soil has been developed that simulates this type of waste.
Fabiola Monroy‐Guzman, Yurihelem Jacobo Cruz, Thelma Selene Jiménez Bravo, Ignacio Alfredo Rivero Espejel, Jorge Anguiano Arévalo, María Dolores Tenorio Castillejos   +5 more
wiley   +1 more source

Synthetic marvels in tuberculosis research: An in-depth review of 1,3,4-oxadiazole derivatives as antitubercular agents

European Journal of Medicinal Chemistry Reports
Given the growth in drug-resistant and inactive cases of tuberculosis, it is imperative to develop novel, potent chemicals to treat this deadly illness.
Isha Kapila, Ankita Bharwal, Poonam Sharma, Neeraj Choudhary, Vikrant Abbot   +4 more
doaj   +1 more source

N-[2-(1H-Indol-3-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethyl]-4-methylbenzenesulfonamide

Molbank, 2018
N-[1-Hydrazinyl-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylbenzenesulfonamide (1) on cyclization with carbon disulfide in ethanolic potassium hydroxide affords N-[2-(1H-indol-3-yl)-1-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)ethyl]-4 ...
Nikil Purushotham, Boja Poojary
doaj   +1 more source

Preparation of heterocyclic block copolymer from perfluoroalkylene oxide alpha, omega-diamidoximes [PDF]

, 1979
Diamidoxime monomers are intermolecularly and thermally condensed to form a heat and chemical resistant polymer containing 1,2,4-oxadiazole linkages with identical bivalent organic radicals or any combination of bivalent organic radicals selected from ...
Iannone, M., Ross, L. O., Rosser, R. W.
core   +1 more source

Molecular Docking and Target‐Specific Binding Profiles of Benzosuberane‐Based Compounds

ChemMedChem, EarlyView.
Benzosuberane represents a promising scaffold in medicinal chemistry. Several benzosuberane‐based derivatives are described in this review as anticancer agents, including antivascular agents, DNA‐intercalators, receptor modulators and kinase inhibitors.
Michail A. Saragatsis, Gemma K. Kinsella, James F. Curtin, Tao Zhang   +3 more
wiley   +1 more source

Synthesis and in vitro antibacterial activity of new oxoethylthio-1,3,4-oxadiazole derivatives

Journal of Saudi Chemical Society, 2014
In the present investigation, a series of 2(4-pyridyl)-5[(aryl/heteroarylamino)-1-oxoethyl]thio-1,3,4-oxadiazole were synthesized using isonicotinohydrazide and substituted aryl/heteroaryl amines using pyridine as solvent.
Jignesh P. Raval, Tarunkumar N. Akhaja, Dhaval M. Jaspara, Kruti N. Myangar, Nilesh H. Patel   +4 more
doaj   +1 more source