Results 1 to 10 of about 32,424 (300)

Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade

Molecules, 2022
The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design ...
Rana M. El-Masry, Hanan H. Kadry, Azza T. Taher, Sahar M. Abou-Seri   +3 more
doaj   +2 more sources

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

International Journal of Molecular Sciences, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +2 more sources

Bioactive Oxadiazoles 3.0. [PDF]

Int J Mol Sci
Heterocycles are fundamental moieties for the construction of new compounds with perspective applications ranging from drugs to materials [...]
Palumbo Piccionello A.
europepmc   +4 more sources

3-(3-Azabicyclo[2, 2, 1]heptan-2-yl)-1,2,4-oxadiazoles as Novel Potent DPP-4 Inhibitors to Treat T2DM [PDF]

Pharmaceuticals
Background: Type 2 diabetes mellitus (T2DM) is a prevalent metabolic disease with global implications, necessitating effective management strategies.
Tatiana V. Zinevich, Ivan O. Maslov, Olga G. Kirichenko, Sergey V. Shorshnev, Maxim A. Gureev, Fedor M. Dolgushin, Yuri B. Porozov, Vladimir M. Trukhan   +7 more
doaj   +2 more sources

Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction

Beilstein Journal of Organic Chemistry, 2017
A versatile continuous-flow synthesis of highly functionalized 1,2,4-oxadiazoles starting from carboxylic acids is reported. This process was applied to the multistep synthesis of imidazo[1,2-a]pyridin-2-yl-1,2,4-oxadiazoles, using a three reactor ...
Ananda Herath, Nicholas D. P. Cosford
doaj   +2 more sources

One-Step Construction of 1,3,4-Oxadiazoles with Anticancer Activity from Tertiary Amines via a Sequential Copper(I)-Catalyzed Oxidative Ugi/aza-Wittig Reaction [PDF]

Molecules
An unparalleled copper(I)-catalyzed synthesis of 1,3,4-oxadiazoles from tertiary amines in one step has been described. The one-pot reactions involving (N-isocyanimine)triphenylphosphorane, tertiary amines, and carboxylic acids resulted in the formation ...
Mei Sun, Nong-Qi Mao, Sheng-Long Wang, Xin-Ming Han, Gang Yao, Ping Xue, Chong-Yang Zeng, Yu-Ting Liu, Kai Chen, Xiao-Qing Gao, Jun Xiong   +10 more
doaj   +2 more sources

In Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of M. tuberculosis Polyketide Synthase 13

Pharmaceuticals, 2023
Benzofuran and 1,3,4-oxadiazole are privileged and versatile heterocyclic pharmacophores which display a broad spectrum of biological and pharmacological therapeutic potential against a wide variety of diseases.
Ali Irfan, Shah Faisal, A. F. Zahoor, Razia Noreen, S. Al-Hussain, Burak Tuzun, Rakshanda Javaid, A. Elhenawy, M. Zaki, Sajjad Ahmad, M. Abdellattif   +10 more
semanticscholar   +1 more source

Synthesis, antimicrobial evaluation and in silico studies of the (E)-3-(aryl)-5-styryl-1,2,4-oxadiazoles

Bioscience Journal, 2022
In recent years, investigations in the field of oxadiazoles have been intensified due to their numerous therapeutic uses. Oxadiazoles are a class of compounds that exhibit several biological applications, citing antimicrobial, anti-inflammatory, anti ...
Josefa Aqueline da Cunha Lima, Erick Caique Santos Costa, Giselle Barbosa Bezerra, Jadson de Farias Silva, Rodrigo Ribeiro Alves Caiana, Joao Rufino de Freitas Filho, Juliano Carlo Rufino Freitas   +6 more
doaj   +1 more source

Room Temperature Synthesis of Bioactive 1,2,4-Oxadiazoles

International Journal of Molecular Sciences, 2023
1,2,4-Oxadiazole is an essential motif in drug discovery represented in many experimental, investigational, and marketed drugs. This review covers synthetic methods that allow the conversion of different types of organic compounds into 1,2,4-oxadiazole ...
S. Baykov, A. Shetnev, A. Semenov, S. O. Baykova, V. Boyarskiy   +4 more
semanticscholar   +1 more source

Synthesis of 2,5-Dialkyl-1,3,4-oxadiazoles Bearing Carboxymethylamino Groups

Molecules, 2022
A series of new symmetrical 2,5-dialkyl-1,3,4-oxadiazoles containing substituted alkyl groups at the terminal positions with substituents, such as bromine, isopropyloxycarbonylmethylamino, and carboxymethylamino, were successfully synthesized.
Marcin Łuczyński, Kornelia Kubiesa, Agnieszka Kudelko   +2 more
doaj   +1 more source