Results 1 to 10 of about 30,682 (325)

A survey of liquid crystalline oxadiazoles [PDF]

ChemInform, 2008
We propose a survey of those oxadiazole compounds, which are mesogenic. We will see that they can have bend-shaped molecules, a biaxial nematic phase, or other interesting peculiarities in the nematic and smectic phase.
Sparavigna, Amelia
core   +5 more sources

In Silico Development of Novel Benzofuran-1,3,4-Oxadiazoles as Lead Inhibitors of M. tuberculosis Polyketide Synthase 13. [PDF]

Pharmaceuticals (Basel), 2023
Benzofuran and 1,3,4-oxadiazole are privileged and versatile heterocyclic pharmacophores which display a broad spectrum of biological and pharmacological therapeutic potential against a wide variety of diseases.
Irfan A, Faisal S, Zahoor AF, Noreen R, Al-Hussain SA, Tuzun B, Javaid R, Elhenawy AA, Zaki MEA, Ahmad S, Abdellattif MH.   +10 more
europepmc   +2 more sources

Strategies against nonsense: oxadiazoles as translational readthrough-inducing drugs (TRIDs) [PDF]

International Journal of Molecular Sciences, 2019
This review focuses on the use of oxadiazoles as translational readthrough-inducing drugs (TRIDs) to rescue the functional full-length protein expression in mendelian genetic diseases caused by nonsense mutations.
Campofelice A., Di Leonardo A., Lentini L., Melfi R., Pace A., Pibiri I., Tutone M.   +6 more
core   +2 more sources

Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions

Beilstein Journal of Organic Chemistry, 2021
Acetylene derivatives of 1,2,4-oxadiazoles, i.e., 5-(2-arylethynyl)-3-aryl-1,2,4-oxadiazoles, have been obtained, for the first time reported, from 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles by their bromination at the carbon–carbon double bond followed ...
Andrey I Puzanov, Dmitry S Ryabukhin, Dmitriy N Zakusilo   +2 more
exaly   +2 more sources

Comparative Study of the Synthetic Approaches and Biological Activities of the Bioisosteres of 1,3,4-Oxadiazoles and 1,3,4-Thiadiazoles over the Past Decade

Molecules, 2022
The bioisosteres of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles are well-known pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1,3,4-oxa-/thiadiazole nuclei have been very attractive to researchers for drug design ...
Rana M. El-Masry, Hanan H. Kadry, Azza T. Taher, Sahar M. Abou-Seri   +3 more
doaj   +2 more sources

Bioactive Oxadiazoles 3.0. [PDF]

Int J Mol Sci
Heterocycles are fundamental moieties for the construction of new compounds with perspective applications ranging from drugs to materials [...]
Palumbo Piccionello A.
europepmc   +4 more sources

Metal-free hydroarylation of the side chain carbon–carbon double bond of 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles in triflic acid

Beilstein Journal of Organic Chemistry, 2017
The metal-free reaction of 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles with arenes in neat triflic acid (TfOH, CF3SO3H), both under thermal and microwave conditions, leads to 5-(2,2-diarylethyl)-3-aryl-1,2,4-oxadiazoles.
Aleksander V Vasilyev, Marina Tarasenko, Alexander Yu Ivanov   +2 more
exaly   +2 more sources

Batch Versus Flow Lithiation-Substitution of 1,3,4-Oxadiazoles: Exploitation of Unstable Intermediates Using Flow Chemistry [PDF]

Chemistry, 2019
1,3,4-Oxadiazoles are a common motif in pharmaceutical chemistry, but few convenient methods for their modification exist. A fast, convenient, high yielding and general α-substitution of 1,3,4-oxadiazoles has been developed using a metalation ...
Barker, Graeme, Tobin, John M., Vilela, Filipe, Wong, Jeff Y. F.   +3 more
core   +2 more sources

1,3,4-Oxadiazoles by Ugi-Tetrazole and Huisgen Reaction [PDF]

Organic Letters, 2019
Easy to perform, functional group tolerant, and short syntheses of the privileged scaffold oxadiazole are highly desired. Here, a metal-free protocol for MCR-based synthesis of 2,5-disubstituted 1,3,4-oxadiazoles via a Ugi-tetrazole/Huisgen sequence was ...
Dömling, Alexander, Konstantinidou, Markella, Mgimpatsang, Kumchok C., Shishkina, Svitlana V., Wang, Qian   +4 more
core   +2 more sources

Tandem Intramolecular Diels–Alder/1,3-Dipolar Cycloaddition Cascade of 1,3,4-Oxadiazoles: Initial Scope and Applications

Accounts of Chemical Research, 2016
A summary of the development and initial studies on the scope of a powerful tandem intramolecular [4 + 2]/[3 + 2] cycloaddition cascade of 1,3,4-oxadiazoles is detailed and provides the foundation for its subsequent use in organic synthesis.
Dale L Boger
exaly   +2 more sources