Results 11 to 20 of about 32,424 (300)

Activity Profiling of Nitro-Substituted Di(Hetero)Aryl 1,3,4- and 1,2,4-Oxadiazoles: Antimicrobial, Cholinesterase Inhibition and Antioxidant Potential. [PDF]

Arch Pharm (Weinheim)
Novel nitro‐substituted diaryl 1,3,4‐ and 1,2,4‐oxadiazoles were synthesised via molecular hybridisation of bioactive heterocycles. Selected derivatives exhibited potent antimicrobial activity, including against Mycobacterium tuberculosis and Staphylococcus aureus, and cholinesterase inhibitory activity, with promising selectivity.
Šikorová E, Štěpánková Š, Frýbová E, Konečná K, Korbielová J, Švarcová M, Janďourek O, Pflégr V, Bősze S, Krátký M.   +9 more
europepmc   +2 more sources

Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design. [PDF]

Angew Chem Int Ed Engl
Modern chemistry seeks to turn the simple raw materials into complex molecules that matter in health, agriculture, and technology. Among these, oligoheterocycles stand out for their versatility, yet they are most often built by cross‐coupling reactions that often rely on expensive metal catalysts.
Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK.   +6 more
europepmc   +3 more sources

BTEAC Catalyzed Ultrasonic-Assisted Synthesis of Bromobenzofuran-Oxadiazoles: Unravelling Anti-HepG-2 Cancer Therapeutic Potential through In Vitro and In Silico Studies

International Journal of Molecular Sciences, 2023
In this work, BTEAC (benzyl triethylammonium chloride) was employed as a phase transfer catalyst in an improved synthesis (up to 88% yield) of S-alkylated bromobenzofuran-oxadiazole scaffolds BF1-9. These bromobenzofuran-oxadiazole structural hybrids BF1-
Ali Irfan, A. F. Zahoor, A. Rasul, S. Al-Hussain, Shah Faisal, Sajjad Ahmad, Rida Noor, M. T. Muhammed, M. Zaki   +8 more
semanticscholar   +1 more source

Synthesis and Biological Activity of 1,3,4-Oxadiazoles Used in Medicine and Agriculture

Applied Sciences, 2022
Biologically active compounds play a key role in the fight against diseases affecting both human and animal living organisms, as well as plants. Finding out about new molecules with a potential biological effect, not yet described in the literature, is ...
Marcin Luczynski, A. Kudelko
semanticscholar   +1 more source

Synthesis of 5-arylacetylenyl-1,2,4-oxadiazoles and their transformations under superelectrophilic activation conditions

Beilstein Journal of Organic Chemistry, 2021
Acetylene derivatives of 1,2,4-oxadiazoles, i.e., 5-(2-arylethynyl)-3-aryl-1,2,4-oxadiazoles, have been obtained, for the first time reported, from 5-(2-arylethenyl)-3-aryl-1,2,4-oxadiazoles by their bromination at the carbon–carbon double bond followed ...
Andrey I. Puzanov, Dmitry S. Ryabukhin, Anna S. Zalivatskaya, Dmitriy N. Zakusilo, Darya S. Mikson, Irina A. Boyarskaya, Aleksander V. Vasilyev   +6 more
doaj   +1 more source

Synthesis and Pharmacological Characterization of Metronidazole-Oxadiazole Derivatives [PDF]

Iranian Journal of Medical Sciences, 2023
Background: The use of antibiotics with or without prescription is increasing worldwide. With certain limitations, metronidazole (MTZ) is extensively used as an antibacterial and antiparasitic drug.
Mohsin Mohammed, Nadia Haj
doaj   +1 more source

A review on synthetic account of 1,2,4-oxadiazoles as anti-infective agents

Molecular diversity, 2022
Most of the currently marketed drugs consist of heterocyclic scaffolds containing nitrogen and or oxygen as heteroatoms in their structures. Several research groups have synthesized diversely substituted 1,2,4-oxadiazoles as anti-infective agents having ...
Tejas M. Dhameliya, Shrddhaba J. Chudasma, Tanvi M. Patel, B. Dave   +3 more
semanticscholar   +1 more source

Biologically oriented synthesis of medicines (BIODS) based on heterylpoxid 2,5-disubstituted 1,3,4-oxadiazoles (Part 2)

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2021
Heterocyclic compounds make a very important branch of organic chemistry, and it has always been an interesting area of study in medical chemistry. They are present in a variety of drugs, vitamins and biologically active compounds. Over two decades, 1,
Yu. V. Karpenko, S. M. Kulish, N. А. Al Halaf   +2 more
doaj   +1 more source

Heterocyclic Compounds as Dipeptidyl Peptidase-IV Inhibitors with Special Emphasis on Oxadiazoles as Potent Anti-Diabetic Agents

Molecules, 2022
Dipeptidyl peptidase-IV (DPP-IV) inhibitors, often known as gliptins, have been used to treat type 2 diabetes mellitus (T2DM). They may be combined with other medications as an additional treatment or used alone as a monotherapy.
Badrud Duza Mohammad, Mirza Shahed Baig, N. Bhandari, F. Siddiqui, S. L. Khan, Zubair Ahmad, Farhat S. Khan, Priti Tagde, P. Jeandet   +8 more
semanticscholar   +1 more source

Synthesis and characterization of new phthalimides and succinimides substituted with 1,3,4-oxadiazole ring [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2012
A series of new phthalimides and succinimides connected to 1,3,4-oxadiazole moiety were synthesized via multistep synthesis. The first step involved synthesis of six 5- substituted 2- amino-1,3,4-oxadiazoles by oxidative cyclization of substituted ...
Ahlam Marouf Al-Azzawi, Hiba Kadhum Yaseen   +1 more
doaj   +1 more source