Results 71 to 80 of about 18,651 (251)

Halogenated and Nonhalogenated Metabolites from the Marine-Alga-Endophytic Fungus Trichoderma asperellum cf44-2

Marine Drugs, 2018
One new bisabolane sesquiterpene, bisabolan-1,10,11-triol (1), one new norbisabolane sesquiterpene, 12-nor-11-acetoxybisabolen-3,6,7-triol (2), two new naturally occurring monoterpenes, (7S)- and (7R)-1-hydroxy-3-p-menthen-9-oic acids (3 and 4), one new ...
Yin-Ping Song, Feng-Ping Miao, Sheng-Tao Fang, Xiu-Li Yin, Nai-Yun Ji   +4 more
doaj   +1 more source

Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. [PDF]

, 2016
6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (PA-824).
Blaser, Adrian, Denny, William A, Franzblau, Scott G, Gupta, Suman, Launay, Delphine, Ma, Zhenkun, Maes, Louis, Martin, Denis, O'Connor, Patrick D, Thompson, Andrew M, Wan, Baojie, Wang, Yuehong, Yardley, Vanessa   +12 more
core   +3 more sources

1,2,6-thiadiazinones as novel narrow spectrum calcium/calmodulin-dependent protein kinase kinase 2 (CaMKK2) inhibitors [PDF]

, 1983
We demonstrate for the first time that 4H-1,2,6-thiadiazin-4-one (TDZ) can function as a chemotype for the design of ATP-competitive kinase inhibitors. Using insights from a co-crystal structure of a 3,5-bis(arylamino)-4H-1,2,6-thiadiazin-4-one bound to ...
Asquith, Christopher R.M., Godoi, Paulo H., Counago, Rafael M., Laitinen, Tuomo, Scott, John W., Langendorf, Christopher G., Oakhill, Jonathan S., Drewry, David H., Zuercher, William J., Koutentis, Panayiotis A., Willson, Timothy M., Kalogirou, Andreas S.   +11 more
core   +3 more sources

Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles [PDF]

, 2017
New coumarin fused oxazoles were investigated as photosensitive units for carboxylic acid groups using butyric acid as a model compound. 6-Oxo-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl derivatives possessing various (hetero)aromatic substituents at ...
Ana M.S. Soares, Brieke, Dore, Fernandes, Fernandes, Fernandes, Fonseca, Furuta, Ghosh, Givens, Graham Hungerford, Hungerford, Kim, Klán, Lakowicz, Lavis, Lee, Loudwig, M. Sameiro T. Gonçalves, Miller, Morris, Muller, Nguyen, Nudelman, Nudelman, Piloto, Piloto, Piloto, Santini, Shell, Soares, Soares, Soares, Soares, Soares, Susana P.G. Costa, Vidali   +36 more
core   +1 more source

Microhydration Structures of Protonated Oxazole [PDF]

The Journal of Physical Chemistry A, 2019
The initial microhydration structures of the protonated pharmaceutical building block oxazole (Ox), H+Ox-Wn≤4, are determined by infrared photodissociation (IRPD) spectroscopy combined with quantum chemical dispersion-corrected density functional theory calculations (B3LYP-D3/aug-cc-pVTZ).
Kuntal Chatterjee, Otto Dopfer
openaire   +2 more sources

Analysis of the flavonoid component of bioactive New Zealand mānuka (Leptospermum scoparium) honey and the isolation, characterisation and synthesis of an unusual pyrrole [PDF]

, 2013
The flavonoid components of New Zealand mānuka (Leptospermum scoparium) honey have been quantified in a series of 31 honeys of varying non-peroxide antibacterial activity to clarify discrepancies between previous studies reported in the literature. Total
Alber, Dagmar G., Chan, Ching Wan, Deadman, Benjamin Jade, Harry, Elizabeth, Manley-Harris, Merilyn, Wilkins, Alistair L.   +5 more
core   +2 more sources

Development of New Benzo[b]Thiophene‐2‐Carboxamide Derivatives as Advanced Glycation End‐Products Receptor (RAGE) Antagonists

ChemMedChem, Volume 21, Issue 1, January 2026.
A streamlined Ullmann‐Goldberg strategy enabled the synthesis of benzo[b]thiophene‐2‐carboxamides, promising ligands of the pro‐inflammatory RAGE receptor involved in inflammaging and age‐related diseases. LC‐MS, NMR, X‐ray and DFT studies elucidated the copper‐catalyzed mechanism. The lead compound, 3t’, shows inhibitory activity on the sRAGE/AGE2‐BSA
Lisa Bonin, Matthieu Hedouin, Christophe Furman, Ophélie Not, Steve Lancel, Mona Bensalah, Gael Coadou, Eric Boulanger, Sergiu Shova, Hassan Oulyadi, Alina Ghinet   +10 more
wiley   +1 more source

Photochemical approach to functionalized benzobicyclo[3.2.1]octene structures via fused oxazoline derivatives from 4- and 5-(o-vinylstyryl)oxazoles

Beilstein Journal of Organic Chemistry, 2014
Novel cis/trans-4- and cis/trans-5-(2-vinylstyryl)oxazoles have been synthesized by Wittig reactions from the diphosphonium salt of α,α’-o-xylene dibromide, formaldehyde and 4- and 5-oxazolecarbaldehydes, respectively. In contrast, trans-5-(2-vinylstyryl)
Ivana Šagud, Simona Božić, Željko Marinić, Marija Šindler-Kulyk   +3 more
doaj   +1 more source

A pilot study of the novel J-PET plastic scintillator with 2-(4-styrylphenyl)benzoxazole as a wavelength shifter [PDF]

, 2015
For the first time a molecule of 2-(4-styrylphenyl)benzoxazole containing benzoxazole and stilbene groups is applied as a scintillator dopant acting as a wavelength shifter. In this article a light yield of the plastic scintillator, prepared from styrene
Bednarski, T., Białas, P., Czerwiński, E., Danel, A., Gajos, A., Gruntowski, A., Kamińska, D., Kapłon, Ł., Kochanowski, A., Korcyl, G., Kowal, J., Kowalski, P., Kozik, T., Krzemień, W., Kubicz, E., Molenda, M., Moskal, P., Niedźwiecki, Sz., Pałka, M., Raczyński, L., Rudy, Z., Rundel, O., Salabura, P., Sharma, N. G., Silarski, M., Smyrski, J., Strzelecki, A., Słomski, A., Uchacz, T., Wieczorek, A., Wiślicki, W., Zieliński, M., Zoń, N.   +32 more
core   +2 more sources

Transfer Hydrogenation: Advances in Manganese and Nickel Metal Catalysis

Journal of Chemistry, Volume 2026, Issue 1, 2026.
Transfer hydrogenation (TH) of ketones, catalyzed by transition–metal complexes, produces alcohols, which are important building blocks in the pharmaceutical and fine chemical industries. For a long time, catalysts based on noble metals such as ruthenium, rhodium, and iridium have dominated the TH of ketones.
James Kamau, George S. Nyamato, Joanne Ogunah, Munmun Bardhan   +3 more
wiley   +1 more source