Continuous multistep synthesis of 2-(azidomethyl)oxazoles
Beilstein Journal of Organic Chemistry, 2018 An efficient three-step protocol was developed to produce 2-(azidomethyl)oxazoles from vinyl azides in a continuous-flow process. The general synthetic strategy involves a thermolysis of vinyl azides to generate azirines, which react with bromoacetyl ...
Thaís A. Rossa +4 more
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Synthesis of Oxazoles Containing CF3-Substituted Alcohol Unit via Tandem Cycloisomerization/Hydroxyalkylation from N-Propargylamides with Trifluoropyruvates [PDF]
MoleculesOxazoles are important five-membered heterocycles that contain both nitrogen and oxygen atoms. Due to their wide range of biological activities, many oxazoles demonstrate potential for extensive application in various fields, including medicinal ...
Juan-Juan Gao +6 more
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Synthesis and Optical Properties of N-Arylnaphtho- and Anthra[2,3-d]oxazol-2-amines [PDF]
MoleculesOxazole, a versatile and significant heteroarene, serves as a bridge between synthetic organic chemistry and applications in the medicinal, pharmaceutical, and industrial fields.
Yuki Murata +4 more
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Silver mediated one-step synthesis of oxazoles from α-haloketones [PDF]
Journal of Saudi Chemical Society, 2011 An efficient silver mediated one-step synthesis/construction of oxazoles using α-haloketones and primary amides is herein described. The methodology is efficient and simple to perform, giving the desired oxazoles in good to excellent yields.
Christian Spiteri +3 more
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GO/MNPs–TEA–CuI in water: a green and efficient catalytic system for multicomponent preparation of highly substituted imidazoles and oxazoles [PDF]
Frontiers in ChemistryA sustainable and highly efficient catalytic protocol has been developed employing graphene oxide-supported magnetic nanoparticles functionalized with triethanolamine and copper(I) iodide (GO/MNPs–TEA–CuI) for the synthesis of functionalized imidazole ...
Mohamed Abu Shuheil +7 more
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Isomerization of 5-(2H-Azirin-2-yl)oxazoles: An Atom-Economic Approach to 4H-Pyrrolo[2,3-d]oxazoles
Molecules, 2021 An atom economical method for the preparation of variously substituted 4H-pyrrolo[2,3-d]oxazoles was developed on the basis of thermal isomerization of 5-(2H-azirin-2-yl)oxazoles.
Timur O. Zanakhov +4 more
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Divergent photochemical ring-replacement of isoxazoles [PDF]
Nature CommunicationsIsoxazoles, oxazoles, and other five-membered heteroaromatics are prevalent motifs in core structure of pharmaceuticals and agrochemicals. In early-stage drug discovery, it is common practice to prepare libraries of analogues featuring different ...
Yan Xu +5 more
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Development of a method for the synthesis of 2,4,5-trisubstituted oxazoles composed of carboxylic acid, amino acid, and boronic acid [PDF]
Beilstein Journal of Organic Chemistry, 2017 A novel method for the synthesis of trisubstituted oxazoles via a one-pot oxazole synthesis/Suzuki–Miyaura coupling sequence has been developed.
Kohei Yamada +2 more
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Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
Beilstein Journal of Organic Chemistry, 2012 Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of ...
Florian Grundmann +7 more
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Benzo[d]oxazoles from Anilides by N-Deprotonation–O-SNAr Cyclization [PDF]
MoleculesA synthesis of benzo[d]oxazoles by an N-deprotonation–O-SNAr cyclization sequence from anilide precursors is reported. Anilides derived from 2-fluorobenzaldehydes, activated toward SNAr ring closure by C5 electron-withdrawing groups, were prepared and ...
Nash E. Nevels +2 more
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