Results 21 to 30 of about 5,187 (206)
Access to highly substituted oxazoles by the reaction of α-azidochalcone with potassium thiocyanate
Beilstein Journal of Organic Chemistry, 2020 The reactivity of α-azidochalcones has been explored for the preparation of highly substituted oxazoles via a 2H-azirine intermediate. The azidochalcones, when treated with potassium thiocyanate in the presence of potassium persulfate, lead to 2,4,5 ...
Mysore Bhyrappa Harisha +4 more
doaj +1 more source
Enantiomeric Separation of New Chiral Azole Compounds
Molecules, 2021 Twelve new azole compounds were synthesized through an ene reaction involving methylidene heterocycles and phenylmaleimide, producing four oxazoles, five thiazoles, and one pyridine derivative, and ethyl glyoxylate for an oxazole and a thiazole compound.
Marziyeh E. Kenari +9 more
doaj +1 more source
Beilstein Journal of Organic Chemistry, 2017 A novel method for the synthesis of trisubstituted oxazoles via a one-pot oxazole synthesis/Suzuki–Miyaura coupling sequence has been developed.
Kohei Yamada +2 more
doaj +1 more source
Monosubstituted Oxazoles. 1. Synthesis of 5-Substituted Oxazoles by Directed Alkylation
, 2016 A general method is presented for synthesis of 2-(methylthio)-5-substituted oxazoles 2. Deprotonation of the readily available 2-(methylthio)oxazole (1) with n-BuLi occurs smoothly in the presence of TMEDA and regiospecifically at C5.
Tadeusz F. Molinski (1313355) +1 more
core +2 more sources
Proceedings, 2019 Six 1,3-oxazoles were synthetized in moderate to good yields by Van Leusen reaction in a pressure reactor. The methodology allowed to decrease the reaction times reported in the literature from hours to 20 min.
Verónica G. García-Ramírez +4 more
doaj +1 more source
Angewandte Chemie, EarlyView.A metal‐free photocatalytic platform converts nitrones into 4‐isoxazolines and oxa–aza–bicycloheptanes through divergent [3+2π/σ] cycloadditions. Assembly‐controlled kinetic electron transfer gating dictates substrate activation, enabling selective reactivity beyond thermodynamic expectations.
Nayan Saha +6 more
wiley +2 more sources
Angewandte Chemie, EarlyView.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
Diazocarbonyl and Related Compounds in the Synthesis of Azoles
Molecules, 2021 Diazocarbonyl compounds have found numerous applications in many areas of chemistry. Among the most developed fields of diazo chemistry is the preparation of azoles from diazo compounds.
Anton Budeev +3 more
doaj +1 more source
Angewandte Chemie, EarlyView.Modular access to underexplored C5‐sulfenyl thiazoles via an intermolecular Pummerer rearrangement is reported. The methodology exhibits a broad functional group tolerance enabling the seamless design of trisubstituted thiazole cores bearing a sulfur handle for further elaboration.
Joe L. Smy +5 more
wiley +2 more sources
Gold Catalyzed Multicomponent Reactions beyond A3 Coupling
Molecules, 2018 The preparation of complex architectures has inspired the search for new methods and new processes in organic synthesis. Multicomponent reactions have become an interesting approach to achieve such molecular diversity and complexity.
Renso Visbal +3 more
doaj +1 more source