Results 41 to 50 of about 5,187 (206)
Molecules, 2020 Mesoionics are neutral compounds that cannot be represented by a fully covalent or purely ionic structure. Among the possible mesomeric structures of these compounds are the diradical electronic configurations.
Antonio João da Silva Filho +2 more
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Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
European Journal of Medicinal Chemistry Reports, 2021 Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabetic ...
Marilia Barreca +7 more
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Química Nova, 1999 A review of heterocyclic compounds in roasted coffee is presented. The contents, precursors and sensorial properties of furans, pyrroles, oxazoles, thiazoles, thiophenes, pyrazines and pyridines are discussed.
Carlos Alberto Bastos De Maria +2 more
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Applied Sciences, 2022 In this paper, we report on the antimicrobial activity assessment of 49 compounds previously synthesized as derivatives of alanine or phenylalanine that incorporate a 4-(4-X-phenylsulfonyl)phenyl fragment (X = H, Cl, or Br), namely 21 acyclic compounds ...
Theodora-Venera Apostol +8 more
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Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Angewandte Chemie International Edition, EarlyView.Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +1 more source
Azole γ‐Peptides Helix Switching via Heterocycle Substitutions
Angewandte Chemie, Volume 138, Issue 36, 1 September 2026.Heterocycle substitution in azole‐based γ‐amino acids enables control over the helical shape of heterocyclic γ‐peptides. S↔N permutation in thiazole residues switches a canonical 9‐helix into a flexible helix exhibiting discontinuous hydrogen bonding.
Samantha Chaise +10 more
wiley +2 more sources
MoleculesThe procedure for the generation of azirinyl-substituted nitrile oxides by the reaction of 2-(diazoacetyl)-2H-azirines with tert-butyl nitrite while preserving the azirine ring has been developed.
Alexander S. Dudik +4 more
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Beilstein Journal of Organic Chemistry, 2014 Novel cis/trans-4- and cis/trans-5-(2-vinylstyryl)oxazoles have been synthesized by Wittig reactions from the diphosphonium salt of α,α’-o-xylene dibromide, formaldehyde and 4- and 5-oxazolecarbaldehydes, respectively. In contrast, trans-5-(2-vinylstyryl)
Ivana Šagud +3 more
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Inter- and intramolecular Diels-Alder/retro-Diels-Alder reactions of 4-silylated oxazoles [PDF]
ARKIVOC, 2002 4-Silylated oxazoles have been shown to undergo inter- and intramolecular Diels-Alder/retro-Diels-Alder reactions with electron-poor alkynes to generate polysubstituted furans.
Pascal C. Ducept, Stephen P. Marsden
doaj +2 more sources
Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion
Chemistry – A European Journal, EarlyView.An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang +10 more
wiley +1 more source