Results 51 to 60 of about 4,839 (215)
Química Nova, 1999 A review of heterocyclic compounds in roasted coffee is presented. The contents, precursors and sensorial properties of furans, pyrroles, oxazoles, thiazoles, thiophenes, pyrazines and pyridines are discussed.
Carlos Alberto Bastos De Maria +2 more
doaj +1 more source
Applied Sciences, 2022 In this paper, we report on the antimicrobial activity assessment of 49 compounds previously synthesized as derivatives of alanine or phenylalanine that incorporate a 4-(4-X-phenylsulfonyl)phenyl fragment (X = H, Cl, or Br), namely 21 acyclic compounds ...
Theodora-Venera Apostol +8 more
doaj +1 more source
Recurrence of the oxazole motif in tubulin colchicine site inhibitors with anti-tumor activity
European Journal of Medicinal Chemistry Reports, 2021 Because of its wide spectrum of targets and biological activities, the oxazole ring is a valuable heterocyclic scaffold in the design of new therapeutic agents with anticancer, antiviral, antibacterial, anti-inflammatory, neuroprotective, antidiabetic ...
Marilia Barreca +7 more
doaj +1 more source
Discovery of CRBN‐based molecular glue degraders targeting WIZ transcription factor
Bulletin of the Korean Chemical Society, EarlyView.This work reports the discovery of 9l, a novel cereblon‐based molecular glue degrader which targets the WIZ transcription factor. Compound 9l facilitates WIZ‐CRBN ternary complex formation to degrade WIZ, subsequently inducing γ‐globin expression in HUDEP‐2 cells and highlighting its potential as a sickle cell disease therapy.
Tae‐Jun Kim +8 more
wiley +1 more source
Chemistry – A European Journal, EarlyView.A straightforward one‐step protocol enables the synthesis of bio‐based and biologically active isochromans through the Oxa‐Pictet cyclization involving diverse aldehydes, including vanillin in combination with lignin‐derivable homovanillyl alcohol, a prominent aromatic platform chemical obtainable via diol‐assisted fractionation of lignocellulose ...
Anjali Kottayi +6 more
wiley +1 more source
MoleculesThe procedure for the generation of azirinyl-substituted nitrile oxides by the reaction of 2-(diazoacetyl)-2H-azirines with tert-butyl nitrite while preserving the azirine ring has been developed.
Alexander S. Dudik +4 more
doaj +1 more source
Chemistry – A European Journal, EarlyView.A series of thirteen (N‐heterocyclic carbene) NHC‐stabilized borenium cations is synthesized from NHC→BH3 complexes via hydroboration and condensation with diols. The novel compounds are fully characterized. Eight crystal structures are presented. Kinetic and NMR data show how the structural features translate to catalytic activity in hydrosilylation ...
Michał Jakubczyk +4 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2014 Novel cis/trans-4- and cis/trans-5-(2-vinylstyryl)oxazoles have been synthesized by Wittig reactions from the diphosphonium salt of α,α’-o-xylene dibromide, formaldehyde and 4- and 5-oxazolecarbaldehydes, respectively. In contrast, trans-5-(2-vinylstyryl)
Ivana Šagud +3 more
doaj +1 more source
European Journal of Organic Chemistry, EarlyView.Straightforward access to oxazole‐containing piperidines through a multicomponent reaction from α‐isocyanoacetates is described. By expanding the reactivity of these a‐isocyanoacetates from aldehydes to ketones, this process efficiently delivers oxazolyl‐piperidines bearing a quaternary stereocenter as valuable scaffolds relevant to drug discovery. The
Roshan Chandrakant Kajare +3 more
wiley +1 more source
Rhodium carbenoid route to oxazoles [PDF]
, 1994 This thesis describes investigations by the author into the preparation of the oxazole heterocyclic system, by the use of rhodium carbenoid methodology.
Kevin J. Doyle (2426908)
core +1 more source