Results 51 to 60 of about 5,322 (210)
MoleculesThe procedure for the generation of azirinyl-substituted nitrile oxides by the reaction of 2-(diazoacetyl)-2H-azirines with tert-butyl nitrite while preserving the azirine ring has been developed.
Alexander S. Dudik +4 more
doaj +1 more source
Nucleophilic Aromatic Substitution in the Gas Phase
Journal of Physical Organic Chemistry, Volume 39, Issue 11, November 2026.In this review, we highlight experimental studies of gas‐phase SNAr. Studying reactions in the gas phase provides invaluable information on intrinsic reactivity by eliminating the complications of solvent effects. Because SNAr is a fundamental reaction in chemical research and organic synthesis, understanding its underlying reactivity and mechanisms is
Daniel N. Hirsch +2 more
wiley +1 more source
Beilstein Journal of Organic Chemistry, 2014 Novel cis/trans-4- and cis/trans-5-(2-vinylstyryl)oxazoles have been synthesized by Wittig reactions from the diphosphonium salt of α,α’-o-xylene dibromide, formaldehyde and 4- and 5-oxazolecarbaldehydes, respectively. In contrast, trans-5-(2-vinylstyryl)
Ivana Šagud +3 more
doaj +1 more source
A KATing Edge Perspective on KAT6A Inhibitors as Anticancer Agents
ChemMedChem, Volume 21, Issue 20, 28 October 2026.This perspective efficiently summarizes the development of lysine acetyltransferase (KAT) inhibitors as anticancer agents, and the most clinically advanced KAT6A inhibitor, prifetrastat, entered Phase III clinical trials in 2025. KAT6A structural biology and structure activity relationships for acylsulfonylhydrazides, [1,2,4]thiadiazines, and ...
Rochelle Woodland +7 more
wiley +1 more source
Isocyano Enones: Addition–Cyclization Cascade to Oxazoles
, 2016 Copper iodide catalyzes the conjugate addition of organometallic and heteroatom nucleophiles to isocyano enones to afford oxazoles. A range of enolates, metalated nitriles, amines, and thiols undergo catalyzed conjugate addition to cyclic and acyclic ...
Fraser F. Fleming (1520524) +2 more
core +1 more source
Angewandte Chemie, Volume 138, Issue 40, 28 September 2026.Peptide‐to‐Small Molecule Paradigm: Peptidomimetics have evolved from simple mimicry toward drug‐like scaffolds supported by increasing clinical successes. This Perspective highlights the geometric design principles—linear repetition, convergent fusion, and cyclization—defining the next‐generation peptidomimetic architectures capable of targeting ...
Jesang Lee +5 more
wiley +2 more sources
Rapid Access to Photoswitchable RNA Binders: Fluorination Enhances Protein Rescue by Exon Inclusion
Chemistry – A European Journal, Volume 32, Issue 39, 22 October 2026.An adaptable approach, many light‐switchable RNA binders. We report a versatile strategy for rapidly synthesizing photoswitchable RNA binders. The ligands can target SMN2 pre‐mRNA, restoring the levels of the corresponding protein by exon‐inclusion rescue.
Lei Zhang +10 more
wiley +1 more source
Nickel-Catalyzed Synthesis of Oxazoles via C−S Activation
, 2016 The synthesis of 2-substituted oxazoles is achieved via nickel-catalyzed cross-coupling reaction of 2-methylthio-oxazole and various organozinc reagents.
Kyoungsoo Lee (2385946) +2 more
core +1 more source
, 2013 The reaction of N-sulfonyl propargylamides in the presence of a base catalyst selectively affords 5-sulfonylmethyl oxazoles via 1,4-sulfonyl migration. Allenes have been established as the key intermediates.
Wan, Boshun +5 more
core +1 more source
General Methodology for the Preparation of 2,5-Disubstituted-1,3-oxazoles
, 2016 Deprotonation of 2-(phenylsulfonyl)-1,3-oxazole (1) readily provides a useful C-5 carbanion that is reactive with a variety of electrophiles. Aldehydes and ketones are useful substrates, and the formation of 5-iodo- and 5-tri-n-butylstannyl oxazoles ...
Liangfeng Fu (1863826) +1 more
core +1 more source