Photoactivatable prodrugs of butyric acid based on new coumarin fused oxazole heterocycles [PDF]
, 2017 New coumarin fused oxazoles were investigated as photosensitive units for carboxylic acid groups using butyric acid as a model compound. 6-Oxo-6H-benzopyrano[6,7-d]oxazol-8-yl)methyl derivatives possessing various (hetero)aromatic substituents at ...
Ana M.S. Soares +36 more
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Repositioning Antitubercular 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazoles for Neglected Tropical Diseases: Structure-Activity Studies on a Preclinical Candidate for Visceral Leishmaniasis. [PDF]
, 2016 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]oxazole derivatives were initially studied for tuberculosis within a backup program for the clinical trial agent pretomanid (PA-824).
Blaser, Adrian +12 more
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Molecules, 2022 An efficient, versatile, and one-pot method for the preparation of novel fluorinated thiazolo- and oxazolo[3,2-a]pyrimidin-7-ones is described from 2-aminothiazoles or 2-amino-oxazoles and fluorinated alkynoates.
Wafa Blancou +4 more
doaj +1 more source
Efficient synthesis of biazoles by aerobic oxidative homocoupling of azoles catalyzed by a copper(I)/2-pyridonate catalytic system. [PDF]
, 2011 A highly efficient and convenient CuCl/2-pyridonate catalytic system for oxidative homocoupling of azoles affording a biazole product has been developed.
Fujita, Ken-ichi +2 more
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1,4- Addition of diazomethane to a heterodiene: a direct preparation of the oxazolic ring
Anais da Academia Brasileira de Ciências, 2007 The reaction of naphthoquinone-oximes (3) and (4) with diazomethane yields directly, in one step, the oxazoles (5) and (6), respectively.A reação das naphthoquinona-oximas (3) e (4) com diazometano fornece diretamente, em uma etapa, os oxazóis (5) e (6),
Flávio da S. Emery +9 more
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Optimization of anti-proliferative activity using a screening approach with a series of bis-heterocyclic G-quadruplex ligands [PDF]
, 2013 Using a phenotypic screening and SAR optimization approach, a phenyl-bis-oxazole derivative has been identified with anti-proliferative activity, optimized with the use of a panel of cancer cell lines.
CIANCIMINO, Cristina +4 more
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Identification and isolation of insecticidal oxazoles from Pseudomonas spp.
Beilstein Journal of Organic Chemistry, 2012 Two new and five known oxazoles were identified from two different Pseudomonas strains in addition to the known pyrones pseudopyronine A and B. Labeling experiments confirmed their structures and gave initial evidence for a novel biosynthesis pathway of ...
Florian Grundmann +7 more
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2-(3-Bromophenyl)imidazo[2,1-b]oxazole
Molbank, 2023 The microwave-assisted reaction of 2-nitroimidazole with 3-bromophenacyl bromide in the presence of potassium carbonate as a base and dimethylformamide as a solvent afforded 2-(3-bromophenyl)imidazo[2,1-b]oxazole.
Ángel Cores +2 more
doaj +1 more source
Synthesis and antitumor activity of mechercharmycin A analogues [PDF]
, 2014 Several analogs of the cytotoxic thiopeptide IB-01211 or Mechercharmycin A (1) have been synthetized. The cytotoxicity of 1 and the synthetized analogs was evaluated against a panel of three human tumor cell lines.
Albericio Palomera, Fernando +5 more
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Beilstein Journal of Organic Chemistry, 2015 The reaction of α-azidochalcones with carboxylic acids has been investigated resulting in the formation of α-amido-1,3-diketones under microwave irradiation via in situ formation of 2H-azirine intermediates.
Kandasamy Rajaguru +4 more
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