Results 71 to 80 of about 14,648 (255)

Total Synthesis of (+)‐Disorazole Z1

Chemistry – A European Journal, EarlyView.
The first total synthesis of disorazole Z1, a highly up to picomolar active cytotoxic natural product, is presented. An acyclic carbon chain containing a chiral quaternary carbon center surrounded by two chiral secondary alcohols was synthesized and combined with a functionalized diene‐stannane to obtain the carbon skeleton of one half of disorazole Z1.
Thomas J. Bauer, Sooroosh Aminian, Oliver Spieß, Dieter Schinzer   +3 more
wiley   +1 more source

High yielding synthesis of oxazole-4-carboxylates from dehydroamino acid derivatives : application as fluorescent markers for peptides [PDF]

, 2010
This work was funded by Foundation for Science and Technology (FCT) and FEDER through CQ-UM, National NMR Network (Bruker 400), research project PTDC/QUI/81238/2006 and PhD grant of G.P.
Castanheira, Elisabete M. S., Ferreira, Paula M. T., Monteiro, Luís S., Pereira, Goreti, Vilaça, Helena   +4 more
core  

A Unique Tryptophan C‐Prenyltransferase from the Kawaguchipeptin Biosynthetic Pathway [PDF]

, 2016
Acknowledgements This work was supported by funding of the Academy of Finland (259505), Helsinki University Research grant (490085) and ESCMID grant (4720572) to D.P.F., University of Pittsburgh Central Research Development Fund to X.L., Technology ...
Arnison, Bent, Donia, Donia, Donia, Houssen, Hulvová, Ishida, Ishida, Koehnke, Leikoski, Leikoski, Leikoski, Li, Magnuson, Martin, McIntosh, Shanks, Sivonen, Tsuji, Wallwey, Williams   +21 more
core   +2 more sources

Synthesis and Optical Properties of N-Arylnaphtho- and Anthra[2,3-d]oxazol-2-amines

Molecules
Oxazole, a versatile and significant heteroarene, serves as a bridge between synthetic organic chemistry and applications in the medicinal, pharmaceutical, and industrial fields.
Yuki Murata, Masato Kawakubo, Ayumi Maruyama, Mio Matsumura, Shuji Yasuike   +4 more
doaj   +1 more source

Naturally Occurring Oxazole-Containing Peptides [PDF]

Marine Drugs, 2020
Oxazole-containing peptides are mostly of marine origin and they form an intriguing family with a broad range of biological activities. Here we classify these peptides on the basis of their chemical structure and discuss a number of representatives of each class that reflect the extraordinary potential of this family as a source of new drugs.
Jessica T. Mhlongo, Fernando Albericio, Fernando Albericio, Edikarlos Brasil, Beatriz G. de la Torre   +4 more
openaire   +3 more sources

Disruption of salt bridge interactions in the inter‐domain cleft of the tubulin‐like protein FtsZ of Escherichia coli makes cells sensitive to the cell division inhibitor PC190723

Cytoskeleton, EarlyView.
Abstract FtsZ forms a ring‐like assembly at the site of division in bacteria. It is the first protein involved in the formation of the divisome complex to split the cell into two halves, indicating its importance in bacterial cell division. FtsZ is an attractive target for developing new anti‐microbial drugs to overcome the challenges of antibiotic ...
Sakshi Mahesh Poddar, Joyeeta Chakraborty, Pananghat Gayathri, Ramanujam Srinivasan   +3 more
wiley   +1 more source

The Cyclisation of l-Aryl-2-Benzamidoalkan-l-Ols to 4,5-DihydroOxazoles or Isoquinolines [PDF]

, 1990
The cyclisation of several N-benzoyl derivatives of 2-amino-l-phenylpropan-l-ol w~e carried out employing the Pictet-Cams modification ofthe BischlerNapieralski reaction. The formation of4, 5-dihydro-oxazoles orisoquinolines depends on the substituents
Md. Sharif, Atan, O. Fitton, Alan
core  

CAB: Towards the RNA-world in the interstellar medium -- detection of urea, and search of 2-amino-oxazole and simple sugars [PDF]

arXiv, 2020
In the past decade, Astrochemistry has witnessed an impressive increase in the number of detections of complex organic molecules. Some of these species are of prebiotic interest such as glycolaldehyde, the simplest sugar, or amino acetonitrile, a possible precursor of glycine. Recently, we have reported the detection of two new nitrogen-bearing complex
arxiv  

Boron in My Mind: A Comprehensive Review of the Evolution of the Diverse Syntheses of 4‐Borono‐l‐Phenylalanine, the Leading Agent for Boron Neutron Capture Therapy

ChemMedChem, EarlyView.
Boron Neutron Capture Therapy is a promising technique for treating “untreatable” brain cancers by having 10B nuclei absorb neutrons and then decay to 7Li destroying the cells they are in. The dominant clinical agent is 4‐borono‐l‐phenylalanine, and this review comprehensively analyzes all of its reported patent and literature syntheses to help ...
Sarfraz Ahmad, Ming Pan, John J. Hayward, Massimo Sementilli, Lisa A. Porter, John F. Trant   +5 more
wiley   +1 more source

Synthesis, Antimycobacterial Activity and Computational Insight of novel 1,4‐Benzoxazin‐2‐one Derivatives as Promising Candidates Against Multidrug‐Resistant M. tuberculosis

ChemMedChem, Accepted Article.
To search for new antitubercular agents, we have designed, synthesized, and evaluated a series of 1,4‐benzoxazinone‐based compounds. These molecules showed potent antimycobacterial activity, with MIC between 2 and 8 μg/mL. This interesting profile included activity against several drug‐resistant strains and minimal cytotoxicity against mammalian Vero ...
Daniele Zampieri, Maria Grazia Mamolo, Emanuele Carosati, Diletta Pasin, Alessandro De Logu, Gianluigi Cabiddu, Marko Jukic   +6 more
wiley   +1 more source