Results 81 to 90 of about 5,687 (109)

Novel oxazolidinone–quinolone hybrid antimicrobials

Bioorganic & Medicinal Chemistry Letters, 2003
Antimicrobial compounds incorporating oxazolidinone and quinolone pharmacophore substructures have been synthesized and evaluated. Representative analogues 2, 5, and 6 display an improved potency versus linezolid against gram-positive and fastidious gram-negative pathogens.
Mikhail F, Gordeev, Corinne, Hackbarth, Michael R, Barbachyn, Lee S, Banitt, James R, Gage, Gary W, Luehr, Marcela, Gomez, Joaquim, Trias, Sara E, Morin, Gary E, Zurenko, Christian N, Parker, Jonathan M, Evans, Richard J, White, Dinesh V, Patel   +13 more
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Linezolid: an oxazolidinone antimicrobial agent

Clinical Therapeutics, 2001
Linezolid is the first oxazolidinone anti-infective agent marketed in the United States. It is indicated for the treatment of nosocomial pneumonia, complicated skin and skin-structure infections caused by methicillin-sensitive or methicillin-resistant Staphylococcus aureus and other susceptible organisms, and vancomycin-resistant Enterococcus faecium ...
H B, Fung, H L, Kirschenbaum, B O, Ojofeitimi   +2 more
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Oxazolidinone: search for highly potent antibacterial

Bioorganic & Medicinal Chemistry Letters, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
Braj Bhushan, Lohray, Vidya Bhushan, Lohray, Brijesh Kumar, Srivastava, Sunil, Gupta, Manish, Solanki, Prashant, Kapadnis, Vijay, Takale, Purvi, Pandya   +7 more
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3-Aryl-2-oxazolidinones through the Palladium-Catalyzed N-Arylation of 2-Oxazolidinones

Organic Letters, 2001
[reaction: see text] 3-Aryl-2-oxazolidinones are obtained in good yields through the palladium-catalyzed N-arylation of 2-oxazolidinones with aryl bromides. The nature of aryl bromides, phosphine ligands, bases, and solvents strongly affects the reaction outcome.
CACCHI, Sandro, FABRIZI, Giancarlo, GOGGIAMANI, ANTONELLA, ZAPPIA G.   +3 more
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Oxazolidinone Antibacterial Agents

Current Pharmaceutical Design, 1996
The oxazolidinones are a new class of synthetic antibacterial agents. These compounds demonstrate potent in vitro and in vivo activity against important human pathogens, including multiple antibiotic-resistant strains of gram positive organisms including the staphylococci, streptococci, and enterococci.
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Oxazolidinone Amide Antibiotics

2016
n ...
Zaharia, CA, Cellamare, Saverio, Altomare, Cosimo Damiano   +2 more
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Linezolid: An oxazolidinone antimicrobial agent

American Journal of Health-System Pharmacy, 2002
The pharmacology, antimicrobial activity, pharmacokinetics, clinical efficacy, and adverse effects of linezolid are reviewed. Linezolid, the only oxazolidinone antimicrobial approved for use in the United States, has significant activity against gram-positive bacteria, including penicillin-, cephalosporin-, and vancomycin-resistant species.
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Oxazolidinones

2006
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Oxazolidinone Antibacterial Agents

2011
The “golden age” of antibacterial agent discovery commenced with the identification of the sulfa drugs in the mid 1930s and concluded with the emergence of the quinolones in the early 1960s (Fig. 8.1). It is interesting to note that the vast majority of these early antibiotics were derived from natural products.
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[Oxazolidinones and glycopeptides].

Enfermedades infecciosas y microbiologia clinica, 2003
We review the chemical structure, pharmacokinetics, antimicrobial spectrum, mechanisms of action and resistance, clinical use and adverse effects of oxazolidinones (linezolid) and glycopeptides. Oxazolidinones inhibit protein synthesis and glycopeptides cell wall synthesis.
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