Palladium-Catalyzed Intramolecular C-H Difluoroalkylation: Synthesis of Substituted 3,3-Difluoro-2-oxindoles [PDF]
, 2014 The synthesis of 3,3-difluoro-2-oxindoles through a robust and efficient palladium-catalyzed C-H difluoroalkylation is described. This process generates a broad range of difluorooxindoles from readily prepared starting materials.
Buchwald, Stephen Leffler +1 more
core +1 more source
High Throughput Screening of a GlaxoSmithKline Protein Kinase Inhibitor Set Identifies an Inhibitor of Human Cytomegalovirus Replication that Prevents CREB and Histone H3 Post-Translational Modification. [PDF]
, 2017 To identify new compounds with anti-human cytomegalovirus (HCMV) activity and new anti-HCMV targets, we developed a high throughput strategy to screen a GlaxoSmithKline (GSK) Published Kinase Inhibitor Set (PKIS).
Ho, CMK +5 more
core +3 more sources
Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination
Angewandte Chemie, Volume 138, Issue 5, 28 January 2026.Despite the remarkable versatility of enzymes for catalyzing complex organic transformations under mild aqueous conditions, no biocatalytic system has been reported for intermolecular C–H fluorination. A radical photoenzymatic approach is introduced that leverages a designed de novo protein scaffold with an unnatural amino acid to achieve precise ...
Yu Zhou +7 more
wiley +2 more sources
Investigating the Antifungal Effects of Spirocyclopropane Oxindoles Derivatives Against Aspergillus Species [PDF]
Research in Molecular Medicine, 2023 Background: Given the increasing resistance of Aspergillus spp. to azoles, finding effective new compounds, such as the spirocyclopropane oxindoles (4a-4b-4c) derivatives, seems necessary.
Amirreza Ardebilifard +8 more
doaj
Stereodivergent propargylic alkylation of enals via cooperative NHC and copper catalysis
Nature Communications, 2022 The ability to construct multiple stereocenters in a modular fashion is an important goal of synthetic organic chemistry. Here the authors present a method to construct oxindoles in four stereoisomers with high enantioselectivity and diastereoselectivity
Yu-Hua Wen +4 more
doaj +1 more source
Catalytic Enantioselective Stereoablative Alkylation of 3-Halooxindoles: Facile Access to Oxindoles with C3 All-Carbon Quaternary Stereocenters [PDF]
, 2009 From 2 to 1! Racemic tertiary halooxindoles proceed to enantioenriched oxindoles bearing all-carbon quaternary stereocenters as a result of a catalytic enantioselective stereoablative process (see scheme). The application of this procedure allows for the
Han, Xiaoqing +4 more
core +1 more source
Azobenzene‐Oxindole Photochromic Dyads
Angewandte ChemieAbstractManipulation of molecular geometry using photoresponsive units is a powerful tool in supramolecular chemistry, smart materials, and photopharmacology. Current synthetic chemistry offers many responsive molecules that perform such a task.
Ovalle, Marco +2 more
openaire +3 more sources
Catalytic enantioselective synthesis of quaternary carbon stereocentres. [PDF]
, 2014 Quaternary carbon stereocentres-carbon atoms to which four distinct carbon substituents are attached-are common features of molecules found in nature. However, before recent advances in chemical catalysis, there were few methods of constructing single ...
Overman, Larry E, Quasdorf, Kyle W
core
Concise Total Synthesis of (+)-Asperazine, (+)-Pestalazine A, and (+)-iso-Pestalazine A. Structure Revision of (+)-Pestalazine A [PDF]
, 2015 The concise, enantioselective total syntheses of (+)-asperazine (1), (+)-iso-pestalazine A (2), and (+)-pestalazine A (3) have been achieved by the development of a late-stage C3–C8′ Friedel–Crafts union of polycyclic diketopiperazines.
Fenton, Owen Shea +2 more
core +2 more sources
Acid‐ and Nucleophile‐Gated Photoisomerization of Phosphaindirubin
Angewandte Chemie International Edition, EarlyView.Triply gated isomerization: In polar solvents, a phosphorus‐containing indirubin photoswitch undergoes visible‐light‐driven Z→E isomerization only when protonated, and reverts thermally via nucleophile‐catalyzed back‐isomerization. This three‐way control by light, acid, and nucleophile enables reversible photoisomerization.
Jacob Jan van der Wal +8 more
wiley +1 more source