Results 101 to 110 of about 80,998 (291)

Atrophic Skeletal Muscle‐Derived Extracellular Vesicles Transfer miR‐125a‐5p to Inhibit Bone Formation in Osteoporosis during Aging

Advanced Science, EarlyView.
A muscle‐bone endocrine pathway in aging is revealed in which extracellular vesicles released from atrophic skeletal muscle (Aged‐SKM‐EVs) inhibit bone formation. These EVs deliver miR‐125a‐5p to osteoblasts, thereby suppressing the SIRT7‐Sp7 signaling axis and osteogenic differentiation.
Xiaoyan Shao, Pan Zhang, Zhidan Fan, Jiaquan Lin, Xiang Chen, Na Liu, Wang Gong, Yi He, Yining Zhou, Tianshu Shi, Yong Shi, Yuze Ma, Wentian Gao, Haosheng Wang, Depeng Fang, Chengzhi Wang, Wenshu Wu, Wenjin Yan, Jianghui Qin, Dongyang Chen, Haiguo Yu, Qing Jiang, Baosheng Guo   +22 more
wiley   +1 more source

Metal-assisted electroless fabrication of nanoporous p-GaN for increasing the light extraction efficiency of light emitting diodes

AIP Advances, 2012
We report metal-assisted electroless fabrication of nanoporous p-GaN to improve the light extraction efficiency of GaN-based light emitting diodes (LEDs).
Ruijun Wang, Duo Liu, Zhiyuan Zuo, Qian Yu, Zhaobin Feng, Xiangang Xu   +5 more
doaj   +1 more source

Infrared behavior in systems with a broken continuous symmetry: classical O(N) model vs interacting bosons

, 2011
In systems with a spontaneously broken continuous symmetry, the perturbative loop expansion is plagued with infrared divergences due to the coupling between transverse and longitudinal fluctuations.
A. A. Abrikosov, A. A. Nepomnyashchy, A. A. Nepomnyashchy, A. A. Nepomnyashchy, A. A. Nepomnyashchy, A. L. Fetter, A. Z. Patashinskii, A. Z. Patashinskii, D. S. Petrov, J. Berges, J. Zinn-Justin, N. Dupuis, N. N. Bogoliubov, N. N. Bogoliubov, P. M. Chaikin, S. K. Ma, S. T. Beliaev, S. T. Beliaev, S. T. Beliaev, S. T. Beliaev, V. N. Popov, V. Popov, V. Popov, Yu. A. Nepomnyashchy, Yu. A. Nepomnyashchy   +24 more
core   +1 more source

High‐Fidelity Synthetic Data Replicates Clinical Prediction Performance in a Million‐Patient Diabetes Cohort

Advanced Science, EarlyView.
This study generates high‐fidelity synthetic longitudinal records for a million‐patient diabetes cohort, successfully replicating clinical predictive performance. However, deeper analysis reveals algorithmic biases and trajectory inconsistencies that escape standard quality metrics. These findings challenge current validation norms, demonstrating why a
Francisco Ortuño, Víctor M. de la Oliva Roque, Javier‐Ignacio Ramirez‐Lopez, David P. Kreil, Joaquín Dopazo, Carlos Loucera   +5 more
wiley   +1 more source

Effects of Switching on the 2-DEG Channel in Commercial E-Mode GaN-on-Si HEMT

Micromachines
In this study, the effects of switching on the two-dimensional electron gas (2-DEG) channel in an E-mode GaN-on-Si HEMT are investigated using a GS-065-004-1-L device that is commercially available for educational practice.
Roberto Baca-Arroyo
doaj   +1 more source

Cryo‐EM Structure Guided Engineering of Botulinum Neurotoxin A With Advanced Receptor Binding Affinity and Therapeutical Benefits

Advanced Science, EarlyView.
The butterfly unfolded wing in an open form structure of botulinum neurotoxin type A (BoNT/A) at physiological‐state was confirmed at 2.85 Å resolution by cryo‐electron microscopy (cryo‐EM). Structure‐guided protein engineering significantly enhanced the receptor‐binding affinity, therapeutic efficacy, and safety of the engineered toxin variants ...
Wenrui Wang, Zhaxi Zerang, Linjin You, Ziye Liu, Rong Nie, Fuwei Qi, Fenfen Gao, Chengmu Zhao, Wantong Ma, Jinghan He, Xiaoru Wang, Shanquan Wu, Bo Liu, Xinyao Liu, Dongsheng Lei, Dejuan Zhi, Dongsheng Wang   +16 more
wiley   +1 more source

Solid Harmonic Wavelet Bispectrum for Image Analysis

Advanced Science, EarlyView.
The Solid Harmonic Wavelet Bispectrum (SHWB), a rotation‐ and translation‐invariant descriptor that captures higher‐order (phase) correlations in signals, is introduced. Combining wavelet scattering, bispectral analysis, and group theory, SHWB achieves interpretable, data‐efficient representations and demonstrates competitive performance across texture,
Alex Brown, Mathilda Avirett‐Mackenzie, Carolin Villforth, Georgios Exarchakis   +3 more
wiley   +1 more source

Photon‐Sphere Modes in Curved Optical Microcavities: A Black‐Hole Analogue Laser

Advanced Science, EarlyView.
An optical analogue of a Schwarzschild black hole is realized using curved microcavities that preserve light‐like geodesics. A new family of laser modes confined around the photon sphere is identified alongside conventional whispering‐gallery modes. Analytical theory, numerical simulations, and experiments reveal curvature‐induced confinement, enabling
Chenni Xu, Aswathy Sundaresan, Nazire‐Begüm Kazkal, Clement Lafargue, Lior Zarfaty, Li‐Gang Wang, Ofek Birnholtz, Dominique Decanini, Melanie Lebental, Patrick Sebbah   +9 more
wiley   +1 more source

Interband Tunneling for Hole Injection in III-Nitride Ultra-violet Emitters

, 2015
Ultra-violet emitters have several applications in the areas of sensing, water purification, and data storage. While the III-Nitride semiconductor system has the band gap region necessary for ultraviolet emission, achieving efficient ultraviolet solid ...
Akyol, Fatih, Allerman, Andrew, Armstrong, Andrew, Hwang, Jinwoo, Johnson, Jared M., Krishnamoorthy, Sriram, Moseley, Michael W., Rajan, Siddharth, Zhang, Yuewei   +8 more
core   +1 more source

A Bottom‐Up Design Framework for Multifunctional Lattice Metamaterials

Advanced Science, EarlyView.
This study introduces a generative AI framework for designing multifunctional lattice metamaterials. The method combines 3D Gaussian voxel generation with deep learning, enabling greater design freedom and structural performance. The optimized lattice metamaterials achieve enhanced energy absorption by 40–200% compared to conventional structures and ...
Zongxin Hu, Quanqing Tao, Junhao Ding, Shuo Qu, Haitao Ye, Jun Wei Chua, Tianxiao Niu, Rui Li, Winston Wai Shing Ma, Haoming Mo, Hui Liu, Wei Zhai, Xinwei Li, Xu Song   +13 more
wiley   +1 more source