Results 21 to 30 of about 507,211 (287)
P-glycoprotein Inhibition for Optimal Drug Delivery
Drug Target Insights, 2013 P-glycoprotein (P-gp), an efflux membrane transporter, is widely distributed throughout the body and is responsible for limiting cellular uptake and the distribution of xenobiotics and toxic substances. Hundreds of structurally diverse therapeutic agents
Md. Lutful Amin
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Química Nova, 2010 Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity.
Paula C. Huber +2 more
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Pharmaceutics, 2023 Triple-negative breast cancer (TNBC) is a highly aggressive disease with rapid progression and poor prognosis due to multidrug resistance (MDR).
Wenwen Xu +5 more
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P-Glycoprotein in Clinical Cardiology [PDF]
Circulation, 1999 Ever since Juliano and Ling first described P-glycoprotein (P-gp) in 1975,1 it has become an important focus of research. P-gp is a member of the ATP-binding cassette (ABC) superfamily of proteins that is highly conserved in distantly related species (from simple eukaryotes to vertebrates).2 These similarities across species suggest that P-gp plays an ...
I, Rodriguez +2 more
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P-glycoprotein expression in retinoblastoma [PDF]
British Journal of Ophthalmology, 2005 We have read with interest the paper by Krishnakumar et al .1 We have studied 18 children with retinoblastoma using immunohistochemical detection of P-glycoprotein by the mouse monoclonal antibody HYB-241 in frozen section tumour samples. Like Krishnakumar et al , we found limited expression of P-glycoprotein in retinoblastoma cells since only four of ...
I J, Dunkel +5 more
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Molecules, 2016 P-glycoprotein (P-gp) affects the transport of many drugs; including puerarin and vincristine. Our previous study demonstrated that imperatorin increased the intestinal absorption of puerarin and vincristine by inhibiting P-gp-mediated drug efflux ...
Zheng-Gen Liao +7 more
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HPLC methods of fexofenadine quantitative analysis in rabbits’ liver
Фармация и фармакология (Пятигорск), 2020 The investigation of pharmacokinetics of marker substrates of carrier protein P-glycoprotein (Pgp, ABCB1-protein) including fexofenadine, is one of the methods of its functional activity evaluation.The aim of the study was to work out the HPLC methods of
P. Yu. Mylnikov +4 more
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Intracellular trafficking of P-glycoprotein [PDF]
The International Journal of Biochemistry & Cell Biology, 2012 Overexpression of P-glycoprotein (P-gp) is a major cause of multidrug resistance in cancer. P-gp is mainly localized in the plasma membrane and can efflux structurally and chemically unrelated substrates, including anticancer drugs. P-gp is also localized in intracellular compartments, such as endoplasmic reticulum (ER), Golgi, endosomes and lysosomes,
Dong, Fu, Irwin M, Arias
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MoleculesP-Glycoprotein (P-gp, also known as MDR1 or ABCB1) is an ATP-binding cassette (ABC) transporter that actively effluxes a wide range of structurally and functionally diverse molecules, playing a crucial role in drug absorption, distribution, and excretion.
Francesco Mastropasqua +3 more
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