Results 21 to 30 of about 21,376,824 (184)

P-glycoprotein inhibitors improve effective dose and time of pregabalin to inhibit intermittent cold stress-induced central pain

Journal of Pharmacological Sciences, 2016
Pregabalin (PGB) is a valuable therapeutic drug against chronic pain. Here we attempted to perform the combinatorial drug therapy with P-glycoprotein (P-gp) inhibitors to lower therapeutic dosage of PGB in the intermittent cold stress-induced ...
Takehiro Mukae, Wakako Fujita, Hiroshi Ueda   +2 more
doaj   +1 more source

Clinical Perspective of FDA Approved Drugs With P-Glycoprotein Inhibition Activities for Potential Cancer Therapeutics

Frontiers in Oncology, 2020
P-glycoprotein (also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) plays a crucial role in determining response against medications, including cancer therapeutics.
Jiun-I. Lai, Yu-Jhen Tseng, Ming-Huang Chen, Chi-Ying F. Huang, P. Chang   +4 more
semanticscholar   +1 more source

The Effect of the Canine ABCB1‐1Δ Mutation on Sedation after Intravenous Administration of Acepromazine

Journal of Veterinary Internal Medicine, 2016
Background Dog breeds with the ABCB1‐1Δ mutation have substantially truncated nonfunctional P‐glycoprotein. Dogs homozygous for this mutation (mut/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine.
D. Deshpande, K.E. Hill, K.L. Mealey, J.P. Chambers, M.A. Gieseg   +4 more
doaj   +1 more source

Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway

Pharmaceutical Biology, 2020
Context Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.
Lin Yang, Chengda Zhang, Jiaoting Chen, Sheng Zhang, Guixuan Pan, Yanfei Xin, Lin Lin, Zhenqiang You   +7 more
doaj   +1 more source

Effect of ethylmethylhydroxypyridine succinate on the functional activity of the transporter P-glycoprotein in the blood-brain barrier of rats under normal conditions and under hypoxic hypoxia

Фармакокинетика и Фармакодинамика, 2022
Relevance. Ethylmethylhydroxypyridine succinate (EMHPS) is a reference domestic drug with pronounced antioxidant and antihypoxic activity. P-Glycoprotein (Pgp) is an ATP-dependent transport protein localized in tissue barriers and protecting cells and ...
P. Yu. Mylnikov, A. V. Shchulkin, I. V. Chernykh, E. N. Yakusheva   +3 more
doaj   +1 more source

Impaired Abcb1a function and red meat in a translational colitis mouse model induces inflammation and alters microbiota composition

Frontiers in Medicine, 2023
Inflammatory Bowel Disease (IBD) affects approximately 0.3% of the global population, with incidence rates rising dramatically worldwide. Emerging evidence points to an interplay between exposome factors such as diet and gut microbiota, host genetics ...
Allan Stensballe, Allan Stensballe, Tue Bjerg Bennike, Gitte Ravn-Haren, Alicja Mortensen, Christopher Aboo, Christopher Aboo, Lina Almind Knudsen, Malte C. Rühlemann, Svend Birkelund, Corinne Bang, Andre Franke, Ulla Vogel, Ulla Vogel, Axel Kornerup Hansen, Vibeke Andersen, Vibeke Andersen, Vibeke Andersen   +17 more
doaj   +1 more source

Effects of P-Glycoprotein and Its Inhibitors on Apoptosis in K562 Cells

Molecules, 2014
P-glycoprotein (P-gp) is a major factor in multidrug resistance (MDR) which is a serious obstacle in chemotherapy. P-gp has also been implicated in causing apoptosis of tumor cells, which was shown to be another important mechanism of MDR recently.
Yaqiong Zu, Zhiyong Yang, Songshan Tang, Ying Han, Jun Ma   +4 more
doaj   +1 more source

Predicting P-glycoprotein-mediated drug transport based on support vector machine and three-dimensional crystal structure of P-glycoprotein. [PDF]

PLoS ONE, 2011
Human P-glycoprotein (P-gp) is an ATP-binding cassette multidrug transporter that confers resistance to a wide range of chemotherapeutic agents in cancer cells by active efflux of the drugs from cells.
Zsolt Bikadi, Istvan Hazai, David Malik, Katalin Jemnitz, Zsuzsa Veres, Peter Hari, Zhanglin Ni, Tip W Loo, David M Clarke, Eszter Hazai, Qingcheng Mao   +10 more
doaj   +1 more source

Multidrug resistance factor - glycoprotein P in rheumatoid arthritis

Научно-практическая ревматология, 2003
Objective. To assess expression of P-glycoprotein (Pgp) on peripheral blood (PB) lymphocytes and its changes during therapy in pts with rheumatoid arthritis (RA). Methods. 51 RA pts and 11 healthy donors (control group) were examined.
I P Kolosova
doaj   +1 more source

Glicoproteína-P, resistência a múltiplas drogas (MDR) e relação estrutura-atividade de moduladores P-glycoprotein and multidrug resistance: structure-activity relationships of modulators

Química Nova, 2010
Multidrug resistance, MDR is a major obstacle for cancer chemotherapy. MDR can be reversed by drugs that vary in their chemical structure and main biological activity.
Paula C. Huber, Cintia H. Maruiama, Wanda P. Almeida   +2 more
doaj   +1 more source