Results 111 to 120 of about 15,815 (221)

P2X7 on mouse T cells: one channel, many functions

Frontiers in Immunology, 2015
The P2X7 receptor is an adenosine triphosphate (ATP)-gated cation channel that is expressed by several cells of the immune system. P2X7 is best known for its proinflammatory role in promoting inflammasome formation and release of mature IL-1β by innate ...
Björn eRissiek, Friedrich eHaag, Olivier eBoyer, Olivier eBoyer, Friedrich eKoch-nolte, Sahil eAdriouch, Sahil eAdriouch   +6 more
doaj   +1 more source

Extracellular ATP and P2X7 receptors in neurodegeneration

European Journal of Pharmacology, 2002
Neuronal injury and cell death in the central nervous system (CNS) are underlying features of neurodegenerative disorders. However, our understanding of the fundamental mechanisms involved is still limited. Inflammatory processes mediated by cytokines, and interleukin-1 (IL-1) in particular, play a significant role in neuronal death following ...
Le Feuvre, Rosalind; id_orcid 0000-0002-9817-9904, Brough, David; id_orcid 0000-0002-2250-2381, Rothwell, Nancy   +2 more
openaire   +3 more sources

Dihydromyricetin Alleviates Diabetic Neuropathic Pain and Depression Comorbidity Symptoms by Inhibiting P2X7 Receptor

Frontiers in Psychiatry, 2019
Diabetic neuropathic pain (DNP) and major depressive disorder (MDD) are common complications of diabetes mellitus and mutually affect each other. As a member of the ATP-gated ion channel family, P2X7 receptor is associated with the transduction of pain ...
Shu Guan, Yulin Shen, Yulin Shen, Huixiang Ge, Wei Xiong, Lingkun He, Lijuan Liu, Cancan Yin, Xingyu Wei, Yun Gao, Yun Gao   +10 more
doaj   +1 more source

P2X7 Receptor Mediated Increase In Cell Membrane Permeability

, 2018
Purinergic receptors consist of two main families; P2X and P2Y. P2Y receptors are G protein coupled receptors (GPCR), whereas P2X receptors are non-selective cation channels. P2X7 receptors which is a member of P2X receptors, have been found myriad types
Kemal Sayar, Șerife Cankurtaran-Sayar
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Emerging key roles for P2X receptors in the kidney [PDF]

, 2013
P2X ionotropic non-selective cation channels are expressed throughout the kidney and are activated in a paracrine or autocrine manner following the binding of extracellular ATP and related extracellular nucleotides.
Peppiatt-Wildman, Claire M., Peppiatt-Wildman, C. M., Wildman, S. S., R. E. Birch, C. M. Peppiatt-Wildman, Scott S Wildman, Schwiebert, E. M., Wildman, Scott S.P., E. M. Schwiebert, S. S. Wildman, Birch, R. E.   +10 more
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miR-150 promotes human breast cancer growth and malignant behavior by targeting the pro-apoptotic purinergic P2X7 receptor.

PLoS ONE, 2013
The P2X7 receptor regulates cell growth through mediation of apoptosis. Low level expression of P2X7 has been linked to cancer development because tumor cells harboring a defective P2X7 mechanism can escape P2X7 pro-apoptotic control.
Songyin Huang, Yongsong Chen, Wei Wu, Nengyong Ouyang, Jianing Chen, Hongyu Li, Xiaoqiang Liu, Fengxi Su, Ling Lin, Yandan Yao   +9 more
doaj   +1 more source

Purinergic receptors in skeletal muscles in health and in muscular dystrophy

, 2014
The P2 purinergic (nucleotide) receptor super-family comprises of two families of protein. The P2X, which are channel-forming ionotropic receptors and the P2Y metabotropic receptors activating G protein-mediated signalling pathways.
Young, Christopher, Zablocki, Krzysztof, Rog, Justyna, Young, Christopher N. J., Rog, J., Gorecki, Dariusz, Zablocki, K., Krasowska, Elzbieta, Sinadinos, Anthony, Gorecki, Darek, Krasowska, E.   +10 more
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P2X7 receptors and klotho [PDF]

Purinergic Signalling, 2020
openaire   +2 more sources

P2X7 receptor-dependent development of gut dysfunction [PDF]

, 2011
©2011. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/ This document is the Accepted, version of a Published Work that appeared in final form in Journal of Immunology.
Martínez, Carlos M., Keating, Christopher, Pelegrin, Pablo, Grundy, David   +3 more
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Purinergic P2x7 receptor: Pathophysiological role in alveolar functions

, 2011
Scope and Method of Study:The present study was initiated to elucidate the role of P2X7 receptor in alveolar functions. P2X7 receptor function was studied in AEC I.
Mishra, Amarjit
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