Results 121 to 130 of about 15,815 (221)

Inhibition of the P2X7 Receptor Reduces Cystogenesis in PKD

, 2011
The P2X7 receptor participates in purinergic signaling, which may promote the progression of ADPKD. We examined the effects of a P2X7 receptor antagonist and a P2X7 receptor agonist on cyst development in a zebrafish model of polycystic kidney disease in
Mai-Szu Wu, Ya-Chung Tian, Yi-Hui Huang, Jenn-Kan Lu, Chih-Wei Yang, Chang, Ming-yang; Lu, Jenn-kan; Tian, Ya-chung; Chen, Yung-chang; Hung, Cheng-chieh; Huang, Yi-hui; Chen, Yau-hung; Wu, Mai-szu; Yang, Chih-wei; Cheng, Yi-chuan, Ming-Yang Chang, Yung-Chang Chen, Yi-Chuan Cheng, Cheng-Chieh Hung, Cheng, Yi-chuan, Yau-Hung Chen   +11 more
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P2X7 receptor knockout does not alter renal function or prevent angiotensin II-induced kidney injury in F344 rats

Scientific Reports
P2X7 receptors mediate immune and endothelial cell responses to extracellular ATP. Acute pharmacological blockade increases renal blood flow and filtration rate, suggesting that receptor activation promotes tonic vasoconstriction.
Josselin Nespoux, Marie-Louise T. Monaghan, Natalie K. Jones, Kevin Stewart, Laura Denby, Alicja Czopek, John J. Mullins, Robert I. Menzies, Andrew H. Baker, Matthew A. Bailey   +9 more
doaj   +1 more source

Proapoptotic plasma membrane pore: P2X7 receptor

, 2001
ATP is not only the universal currency of energy metabolism but also a ubiquitous extracellular messenger. Among its many effects the ability to trigger cell death has attracted considerable interest.
DI VIRGILIO, Francesco, Anna Morelli, Rosario Rizzuto, BOLOGNESI G., Davide Ferrari, MORELLI, ANNA, RIZZUTO, Rosario, Giorgio Bolognesi, FERRARI, Davide, Francesco Di Virgilio   +9 more
core   +1 more source

P2X7 receptor antagonism preserves retinal ganglion cells in glaucomatous mice

, 2020
To investigate the role of P2X7 receptor to preserve retinal ganglion cells (RGCs) structure and function in a genetic mouse model (DBA/2J mouse) of age-related glaucomatous neurodegeneration. Chronic treatment with P2X7 receptor antagonist eye drops was
Lazzara F., Porciatti V., Amato R., Drago F., Romano G. L., Bucolo C., Chou T. -H.   +6 more
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A Mechanism-Based Approach to P2X7 Receptor Action

, 2019
The ligand-gated ion channel P2X7 receptor attracts special attention due to its widespread presence as well as its unusual responses. Besides relatively well-understood mechanisms such as intracellular Ca2+ increase and K+ depletion, the P2X7 receptor ...
Ugur, Mehmet, Ugur, Ozlem
core   +1 more source

The canine P2X7 receptor

, 2012
The P2X7 receptor is a trimeric ligand-gated ion channel, present in many mammalian species including the canine. P2X7 activation by its natural ligand, extracellular adenosine 5´-triphosphate (ATP), leads to the opening of a large non-selective pore ...
Iman Jalilian (543338)
core  

Role of P2X7 receptor in host response to melanoma

, 2014
The P2X7 receptor, for extracellular ATP, is involved in several signaling pathways, including cell death and inflammation. Recently, it has been demonstrated that P2X7 receptor has a pivotal role both in cancer proliferation and anti-tumoral immune ...
ADINOLFI, Elena, FRANCESCHINI, Alessia, DI VIRGILIO, Francesco, ABELLI, Luigi, CAPECE, Marina, A. Rotondo   +5 more
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P2X7 receptor [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

P2X7 receptor [PDF]

Science-Business eXchange, 2010
openaire   +1 more source

The P2X7 purinergic receptor in dogs

, 2013
The P2X7 receptor is an adenosine 5’-triphosphate (ATP)-gated ion channel expressed on the cell-surface of many cell types, including cells of haematopoietic origin and epithelial cells.
Mari Spildrejorde (543339)
core