Results 141 to 150 of about 12,681 (186)

P2X7 receptor in macrophage polarization and its implications in neuroblastoma tumor behavior. [PDF]

Purinergic Signal
Bento CA, Arnaud-Sampaio VF, Glaser T, Adinolfi E, Coutinho-Silva R, Ulrich H, Lameu C.   +6 more
europepmc   +1 more source

Antagonism of the ATP-gated P2X7 receptor inhibits the proliferation of hepatocellular carcinoma cells. [PDF]

Purinergic Signal
Tantai X, Yang X, Liu X, Yang X.
europepmc   +1 more source

The role of the P2X7 receptor in inactivated SARS-CoV-2-induced lung injury. [PDF]

Purinergic Signal
Carvalho-Barbosa NC, Cristina-Rodrigues F, Temerozo JR, Souza TML, Gouvêa AL, Canetti CA, Kurtenbach E, Bou-Habib DC, Benjamim CF, Takiya CM, Savio LEB, Coutinho-Silva R.   +11 more
europepmc   +1 more source

The P2X7 Receptor-Interleukin-1 Liaison [PDF]

Frontiers in Pharmacology, 2017
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g., auto-inflammatory syndromes, as well as common pathologies, such as type II diabetes, gout and atherosclerosis.
Simonetta Falzoni, Francesco Di Virgilio, Anna Lisa Giuliani   +2 more
exaly   +4 more sources

P2X7 Receptor Signaling in Stress and Depression [PDF]

International Journal of Molecular Sciences, 2019
Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is required.
Gregers Wegener, Henning Ulrich, Talita Glaser   +2 more
exaly   +4 more sources

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Tissue distribution of the P2X7 receptor

Neuropharmacology, 1997
The P2X7 receptor is a bifunctional molecule. The binding of ATP induces within milliseconds the opening of a channel selective for small cations, and within seconds a larger pore opens which allows permeation by molecules as large as propidium dyes (629 Da).
COLLO, Luigia Rinalda, NEIDHART S, KAWASHIMA E, KOSCO VILBOIS M, NORTH RA, BUELL G.   +5 more
openaire   +4 more sources

P2X7 receptors in the nervous system

Progress in Neurobiology, 2006
P2X(7) receptors are ligand-gated ion channels, expressed as homo-oligomeric assemblies of individual subunits. They are widely distributed at immunocompetent cells of the central and peripheral nervous system and are believed to be primarily involved in host-defense reaction. However, a growing amount of evidence indicates that their signaling role in
Beáta, Sperlágh, E Sylvester, Vizi, Kerstin, Wirkner, Peter, Illes   +3 more
openaire   +2 more sources

P2X7 receptors in the central nervous system

Biochemical Pharmacology, 2021
For the past three decades, our laboratory has conducted pioneering research to elucidate the complexity of purinergic signaling in the CNS, alone and in collaboration with other groups, inspired by the ground-breaking efforts of Geoffrey Burnstock. This review summarizes our contribution to understand the nucleotide receptor signaling in the CNS with ...
María Teresa Miras-Portugal, Felipe Ortega, Rosa Gómez-Villafuertes, Javier Gualix, Raquel Pérez-Sen, Esmerilda G. Delicado   +5 more
openaire   +2 more sources

Novel P2X7 receptor antagonists

Bioorganic & Medicinal Chemistry Letters, 2003
The synthesis and pharmacological evaluation of a new series of potent P2X(7) receptor antagonists is disclosed. The compounds inhibit BzATP-mediated pore formation in THP-1 cells. The distribution of the P2X(7) receptor in inflammatory cells, most notably the macrophage, mast cell and lymphocyte, suggests that P2X(7) antagonists have a significant ...
L, Alcaraz, A, Baxter, J, Bent, K, Bowers, M, Braddock, D, Cladingboel, D, Donald, M, Fagura, M, Furber, C, Laurent, M, Lawson, M, Mortimore, M, McCormick, N, Roberts, M, Robertson   +14 more
openaire   +2 more sources