Results 81 to 90 of about 15,815 (221)
Channel Dysfunction as the Basis for Comorbidities in Multiple Sclerosis and Depression
Archiv der Pharmazie, Volume 359, Issue 6, June 2026.Ion channel remodelling induced by neuroinflammation in multiple sclerosis alters neuronal excitability and immune signalling, creating shared molecular pathways that link multiple sclerosis pathology to depression and reveal novel pharmacological targets.
Nicole Rychlik +4 more
wiley +1 more source
Macrophage P2X7 Receptor Function Is Reduced during Schistosomiasis: Putative Role of TGF-β1
Mediators of Inflammation, 2014 Schistosomiasis is a chronic inflammatory disease whose macrophages are involved in immunopathology modulation. Although P2X7 receptor signaling plays an important role in inflammatory responses mediated by macrophages, no reports have examined the role ...
Suellen D’arc Santos Oliveira +5 more
doaj +1 more source
Journal of Cell Communication and Signaling, Volume 20, Issue 2, June 2026.Abstract Atrial fibrillation (AF), the most common clinical arrhythmia, is driven by inflammatory activation and oxidative stress, though precise molecular links remain unclear. This study identifies the P2X7 receptor as a key upstream regulator orchestrating proarrhythmic atrial remodeling through reactive oxygen species (ROS)‐mediated mitogen ...
Lingnan Zhang, Yeran Zhu, Xinshun Gu
wiley +1 more source
THE P2X7 RECEPTOR OF HUMAN LEUKOCYTES [PDF]
, 2003 Lymphocytes from normal subjects and patients with B-chronic lymphocytic leukemia (B-CLL) show functional responses to extracellular ATP characteristic of the P2X7 receptor. These responses include opening of a cation selective channel/pore which allows
Gu, Baijun
core
Molecular Pain, 2022 Background The transition from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype presents a novel therapeutic strategy for chronic pain.
Ping Wu +5 more
doaj +1 more source
Progress of Immunotherapies in Parkinson's Disease
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng +10 more
wiley +1 more source
The role of p2x7 receptor in infectious inflammatory diseases and the influence of ectonucleotidases
Biomedical Journal, 2014 The purinergic receptor P2X ligand-gated ion channel 7 (P2X7) is ubiquitously expressed in almost all tissues and organs of the body with the highest distribution in the immune cells of monocyte-macrophage origin.
Ana Carolina Morandini +2 more
doaj +1 more source
The Silent Link: Exploring the Impact of Periodontal Diseases on Head and Neck Carcinogenesis
Clinical and Experimental Dental Research, Volume 12, Issue 3, June 2026.ABSTRACT Objectives Oral dysbiosis can accelerate the progression of head and neck squamous cell carcinoma (HNSCC) by fostering a pro‐inflammatory, immunosuppressive, and metabolically altered environment. This narrative review examines the relationships between periodontitis‐associated bacteria and HNSCC, focusing on their impact on oncogenic pathways,
Yashmin Afshar, Nima Rezaei
wiley +1 more source
The P2X7 receptor: A main player in inflammation
Biochemical Pharmacology, 2018 Damage associated molecular patterns (DAMPs) are intracellular molecules released from infected or injured cells to activate inflammatory and reparatory responses. One of the most ancient and conserved DAMPs is extracellular ATP that exerts its phlogistic activity mainly through activation of the P2X7 receptor (P2X7R).
Adinolfi, Elena +5 more
openaire +3 more sources
The P2X7 Carboxyl Tail Is a Regulatory Module of P2X7 Receptor Channel Activity [PDF]
Journal of Biological Chemistry, 2008 P2X(7) receptors are ATP-gated cation channels composed of three identical subunits, each having intracellular amino and carboxyl termini and two transmembrane segments connected by a large ectodomain. Within the P2X family, P2X(7) subunits are unique in possessing an extended carboxyl tail.
Daniel, Becker +6 more
openaire +2 more sources