Results 61 to 70 of about 15,815 (221)
Genetics of the P2X7 receptor and human disease [PDF]
Purinergic Signalling, 2009 The P2RX7 gene is highly polymorphic, and many single nucleotide polymorphisms (SNPs) underlie the wide variation observed in P2X7 receptor responses. We review the discovery of those non-synonymous SNPs that affect receptor function and compare their frequencies in different ethnic populations. Analysis of pairwise linkage disequilibrium (LD) predicts
Stephen J, Fuller +4 more
openaire +2 more sources
P2X7 Receptor–Mediated Inflammation in Cardiovascular Disease
Frontiers in Pharmacology, 2021 Purinergic P2X7 receptor, a nonselective cation channel, is highly expressed in immune cells as well as cardiac smooth muscle cells and endothelial cells.
Junteng Zhou +9 more
doaj +1 more source
Electrochemical Three‐Component Synthesis of Heteroaryl Sulfonates
European Journal of Organic Chemistry, EarlyView.An electrochemical, metal‐free three‐component strategy for direct C(sp2)─H sulfonation of electron‐rich heteroarenes using SO2 and alcohols is described. Utilizing inexpensive graphite electrodes and practical SO2 stock solutions under mild conditions, this method provides straightforward access to heteroaryl sulfonates from simple building blocks ...
Po‐Chung Chien +2 more
wiley +1 more source
P2X7 Receptors: Channels, Pores and More
CNS & Neurological Disorders - Drug Targets, 2012 Purine nucleotides are well established as extracellular signaling molecules. P2X7 receptors (P2X7Rs) are members of the family of ionotropic ATP-gated receptors. Their activity can be found in a limited number of cell types, but is readily detectable in cells of hemopoietic lineage including macrophages, microglia, and certain lymphocytes, and ...
Volont('e), C. +3 more
openaire +3 more sources
International Journal of Cancer, EarlyView.ABSTRACT Clinical trials combining radiotherapy (RT) with immune checkpoint blockade (ICB) have shown improved outcomes in only a fraction of patients, and optimal strategies for integrating these modalities remain under intense investigation. With a few exceptions, phase III combination trials have yielded disappointing results.
Xuanwei Zhang +10 more
wiley +1 more source
PLoS Pathogens, 2019 Leishmaniasis is a neglected tropical disease affecting millions of individuals worldwide. P2X7 receptor has been linked to the elimination of Leishmania amazonensis.
Mariana M Chaves +9 more
doaj +1 more source
Expression and Purification of a Mammalian P2X7 Receptor from Sf9 Insect Cells
Bio-Protocol, 2017 The P2X7 receptor is an extracellular ATP-gated ion channel found only in eukaryotes (Bartlett et al., 2014). Due to its unique properties among P2X receptors, such as formation of a large conductance pore, the P2X7 receptor has been implicated in ...
Akira Karasawa, Toshimitsu Kawate
doaj +1 more source
The potential for biased signalling in the P2Y receptor family of GPCRs
British Journal of Pharmacology, EarlyView.The purinergic receptor family is primarily activated by nucleotides, and contains members of both the G protein coupled‐receptor (GPCR) superfamily (P1 and P2Y) and ligand‐gated ion channels (P2X). The P2Y receptors are widely expressed in the human body, and given the ubiquitous nature of nucleotides, purinergic signalling is involved with a plethora
Claudia M. Sisk +2 more
wiley +1 more source
, 2013 Cells were pre-incubated or not with a specific inhibitor of P2X7 (BBG) at 20 µM for 20 minutes before incubation with HMW-HA or MMW-HA or LMW-HA at 0.2% for 24-hours. P2X7 activation was evaluated by YO-PRO-1 dye uptake.
Jean-Michel Warnet (298323) +3 more
core +1 more source
ImmunobiologyBackground: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 polarization among tumor ...
Qin Si +5 more
doaj +1 more source