Results 51 to 60 of about 15,815 (221)
Advanced Science, EarlyView.ABSTRACT Lung adenocarcinoma (LUAD) remains a leading cause of cancer mortality with limited therapeutic options. Disulfidptosis, a novel cell death modality driven by disulfide stress, represents a promising target, yet its regulation in LUAD is poorly defined. Here, we identify Pannexin 2 (PANX2) as a tumor suppressor in LUAD.
Yi Chen +7 more
wiley +1 more source
P2X7 receptor signaling during adult hippocampal neurogenesis
, 2019 Neurogenesis is a persistent and essential feature of the adult mammalian hippocampus. Granular neurons generated from resident pools of stem or progenitor cells provide a mechanism for the formation and consolidation of new memories.
Lovelace, Michael +16 more
core +1 more source
P2X7 Receptor Function in Bone-Related Cancer [PDF]
, 2012 Modulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host ...
ADINOLFI, Elena +5 more
core +1 more source
P2X7 Receptor Signaling in Stress and Depression [PDF]
International Journal of Molecular Sciences, 2019 Stress exposure is considered to be the main environmental cause associated with the development of depression. Due to the limitations of currently available antidepressants, a search for new pharmacological targets for treatment of depression is required.
Deidiane Elisa Ribeiro +5 more
openaire +3 more sources
P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
Cell Communication and Signaling, 2023 Background The purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 receptor stimulation triggers processing and release of the pro-inflammatory cytokine interleukin (IL)-1β by activation of ...
Judith Bockstiegel +2 more
doaj +1 more source
Animal Models and Experimental Medicine, EarlyView.Scalp electroacupuncture (SA) through activation of the trigeminal pathway exerts anti‐inflammatory, antidepressant, and anxiolytic effects in an animal model of post‐traumatic stress disorder induced by single prolonged stress. This suggests that SA is involved in neuroinflammation and changes in brain‐derived neurotrophic factor protein through the ...
Bombi Lee +3 more
wiley +1 more source
Animal Models for the Investigation of P2X7 Receptors
International Journal of Molecular Sciences, 2023 The P2X7 receptor is a trimeric ligand-gated cation channel activated by extracellular adenosine 5′-triphosphate. The study of animals has greatly advanced the investigation of P2X7 and helped to establish the numerous physiological and pathophysiological roles of this receptor in human health and disease.
Ronald Sluyter +5 more
openaire +3 more sources
The Journal of Headache and Pain, 2021 Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via glutamatergic pathway and also promotes neuroinflammation. • P2X7 receptor/SFKs signaling can be targeted for migraine prophylaxis and therapy.
Lingdi Nie +3 more
doaj +1 more source
Current Issues in Molecular Biology, 2021 Background: Breast cancer is the most common malignancy in women worldwide. P2X7 is a transmembrane receptor expressed in breast cancer and activated by the ATP tumor microenvironment, driving cell proliferation, angiogenesis, and metastasis via ...
Muhammed M. Salahuddin +3 more
doaj +1 more source
Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis
Arthritis &Rheumatology, EarlyView.Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm +2 more
wiley +1 more source