Results 51 to 60 of about 3,904,877 (199)
Function of the P2X7 receptor in hematopoiesis and leukemogenesis [PDF]
Experimental Hematology, 2021 Adenosine triphosphate (ATP) accumulates at tissue injury and inflammation sites. The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, P2X7 receptors also play important roles in the growth of cancer and the immune regulation.
Xiaoxiao, He +5 more
openaire +2 more sources
P2X7 in Cancer: From Molecular Mechanisms to Therapeutics
Frontiers in Pharmacology, 2020 P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response.
Romain Lara +6 more
doaj +1 more source
Cells, 2022 In pregnant women, the lungs, skin and placenta are exposed daily to endocrine-disrupting chemicals (EDCs). EDCs induce multiple adverse effects, not only on endocrine organs, but also on non-endocrine organs, with the P2X7 cell death receptor being ...
Sophie Fouyet +4 more
doaj +1 more source
Characterization of a functional P2X7-like receptor in cerebellar granule neurons from P2X7 knockout mice [PDF]
, 2005 The presence of ionotropic P2X7 receptor has been studied in mice brain from wild type and P2X7 receptor knockout animals. Western blot and immunocytochemical assays show the presence of a protein containing the P2X7 immunogenic epitopes in the brain of ...
Miras-Portugal, M. Teresa +5 more
core +1 more source
Journal of Osteoporosis, 2012 P2X7 receptor-mediated purinergic signaling is a well-known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and ...
Alberto Baroja-Mazo, Pablo Pelegrín
doaj +1 more source
Purinergic signaling mediates oxidative stress in UVA-exposed THP-1 cells
Toxicology Reports, 2015 Ultraviolet A (UVA) radiation, the major UV component of solar radiation, can penetrate easily to the dermis, where it causes significant damage to cellular components by inducing formation of reactive oxygen species (ROS).
Ayumi Kawano +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Neuropathic pain is a complex disease with high incidence. Adenosine triphosphate (ATP) and its activated P2X7 receptor are involved in the signal transmission of neuropathic pain.
Ru-Nan Yang +11 more
semanticscholar +1 more source
Dissecting activation steps in P2X7 receptors
Biochemical and Biophysical Research Communications, 2021 P2X7 receptors are trimeric ion channels activated by extracellular ATP. Upon activation, they trigger cytolysis and apoptosis but also control cell proliferation. To shed more light on channel gating and the underlying function of the individual subunits, receptors of concatenated subunits were built containing a defined number of functional binding ...
Milica Gusic +2 more
openaire +2 more sources
PLoS Pathogens, 2017 A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria.
Érika Machado de Salles +13 more
doaj +1 more source
Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors [PDF]
British Journal of Pharmacology, 2009 Background and purpose: Acute activation of P2X7 receptors rapidly opens a non‐selective cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, mediated by downstream recruitment of hemichannels to the cell surface.
Diana L, Donnelly-Roberts +3 more
openaire +2 more sources