Results 31 to 40 of about 3,904,877 (199)
Gallic Acid Alleviates Visceral Pain and Depression via Inhibition of P2X7 Receptor
International Journal of Molecular Sciences, 2022 Chronic visceral pain can occur in many disorders, the most common of which is irritable bowel syndrome (IBS). Moreover, depression is a frequent comorbidity of chronic visceral pain.
Lequan Wen +12 more
semanticscholar +1 more source
Effect of P2X7 receptor knockout on AQP-5 expression of type I alveolar epithelial cells. [PDF]
PLoS ONE, 2014 P2X7 receptors, ATP-gated cation channels, are specifically expressed in alveolar epithelial cells. The pathophysiological function of this lung cell type, except a recently reported putative involvement in surfactant secretion, is unknown.
Georg Ebeling +5 more
doaj +1 more source
Brain, behavior, and immunity, 2022 Autism spectrum disorder (ASD) is a complex neurodevelopmental condition caused by interactions of environmental and genetic factors. Recently we showed that activation of the purinergic P2X7 receptors is necessary and sufficient to convert maternal ...
Dorottya Szabó +6 more
semanticscholar +1 more source
Irradiation causes senescence, ATP release, and P2X7 receptor isoform switch in glioblastoma
Cell Death and Disease, 2022 Glioblastoma (GBM) is the most lethal brain tumor in adults. Radiation, together with temozolomide is the standard treatment, but nevertheless, relapse occurs in nearly all cases.
M. Zanoni +13 more
semanticscholar +1 more source
Arteriosclerosis, Thrombosis, and Vascular Biology, 2021 Chronic low-grade inflammation contributes to the development of several diseases, including cardiovascular disease. Adequate strategies to target inflammation in cardiovascular disease are in their infancy and remain an avenue of great interest. The purinergic receptor P2X7 is a ubiquitously expressed receptor that predominately mediates inflammation ...
Brandon G. Shokoples +2 more
openaire +2 more sources
Role of P2X7 Receptors in Immune Responses During Neurodegeneration
Frontiers in Cellular Neuroscience, 2021 P2X7 receptors are ion-gated channels activated by ATP. Under pathological conditions, the extensive release of ATP induces sustained P2X7 receptor activation, culminating in induction of proinflammatory pathways with inflammasome assembly and cytokine ...
Ágatha Oliveira-Giacomelli +7 more
doaj +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Unwin, RJ +18 more
core +1 more source
Modulation of Cell Energy Metabolism by the P2X7 Receptor
, 2022 For many years the P2X7 receptor (P2X7R) was considered the prototypic cytolytic receptor due to its ability to cause dramatic changes in plasma membrane permeability, eventually leading to cell death.
Di Virgilio, Francesco +5 more
core +1 more source
Administration of P2X7 Receptor Blockers in Oncological Experimental Models
, 2022 The tumor microenvironment is rich in components that strongly influence cancer cell survival. One of the pivotal molecules present at the tumor bed is ATP, which has an essential role in promoting cancer proliferation and metastasis and immune responses
Adinolfi E., Pegoraro A., De Marchi E.
core +1 more source
Cell Death and Disease, 2021 Tumor growth and metastatic spreading are heavily affected by the P2X7 receptor as well as microvesicles and exosomes release into the tumor microenvironment. P2X7 receptor stimulation is known to trigger vesicular release from immune and central nervous
Anna Pegoraro +11 more
doaj +1 more source