Results 31 to 40 of about 15,815 (221)

Human P2Y11 Expression Level Affects Human P2X7 Receptor-Mediated Cell Death

Frontiers in Immunology, 2018
Adenosine triphosphate (ATP) is known to induce cell death in T lymphocytes at high extracellular concentrations. CD4+ and CD8+ T lymphocytes have a differential response to ATP, which in mice is due to differences in the P2X7 receptor expression levels.
Karin Dreisig, Louise Sund, Maja Wallentin Dommer, Nikolaj Pagh Kristensen, Kim Boddum, Rannveig Viste, Simon Fredholm, Niels Odum, Marja Jäättelä, Søren Skov, Birgitte R. Kornum, Birgitte R. Kornum   +11 more
doaj   +1 more source

Neurochemical Changes in the Mouse Hippocampus Underlying the Antidepressant Effect of Genetic Deletion of P2X7 Receptors. [PDF]

, 2013
Recent investigations have revealed that the genetic deletion of P2X7 receptors (P2rx7) results in an antidepressant phenotype in mice. However, the link between the deficiency of P2rx7 and changes in behavior has not yet been explored.
Zsilla Gabriella, Csölle Cecília, Csölle, Cecília, Illes Peter, Flóra Gölöncsér, Gabriella Zsilla, Mária Baranyi, Sperlágh, Beáta, Baranyi, Mária, Kittel Ágnes, Peter Illes, Baranyi Mária, Beáta Sperlágh, Vizi E. Szilveszter, E Sylvester Vizi, Zsilla, Gabriella, Papp Edit, Gölöncsér Flóra, Illés, Péter, Gölöncsér, Flóra, E. Sylvester Vizi, Sperlágh Beáta, Illes P, Vizi, E. Szilveszter, Papp, Edit, Edit Papp, Kittel, Ágnes, Agnes Kittel, Cecilia Csölle, Vizi E. Sylvester   +29 more
core   +1 more source

P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Frontiers in Immunology, 2017
Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain ...
Maria Barberà-Cremades, Ana I. Gómez, Alberto Baroja-Mazo, Laura Martínez-Alarcón, Carlos M. Martínez, Carlos de Torre-Minguela, Pablo Pelegrín   +6 more
doaj   +1 more source

Rod and cone pathway signalling is altered in the P2X7 receptor knock out mouse.

PLoS ONE, 2012
The P2X7 receptor (P2X7-R) is expressed in the retina and brain and has been implicated in neurodegenerative diseases. However, whether it is expressed by neurons and plays a role as a neurotransmitter receptor has been the subject of controversy.
Kirstan A Vessey, Erica L Fletcher
doaj   +1 more source

The effect of anions on the human P2X7 receptor [PDF]

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2011
P2X7 receptors (P2X7Rs) are nonselective cation channels that are opened by the binding of extracellular ATP and are involved in the modulation of epithelial secretion, inflammation and nociception. Here, we investigated the effect of extracellular anions on channel gating and permeation of human P2X7Rs (hP2X7Rs) expressed in Xenopus laevis oocytes ...
Kubick, Christoph, Schmalzing, Günther, Markwardt, Fritz   +2 more
openaire   +2 more sources

Function of the P2X7 receptor in hematopoiesis and leukemogenesis [PDF]

Experimental Hematology, 2021
Adenosine triphosphate (ATP) accumulates at tissue injury and inflammation sites. The P2X7 receptor is an ATP-gated ion channel known for its cytotoxic activity. However, P2X7 receptors also play important roles in the growth of cancer and the immune regulation.
Xiaoxiao, He, Yaping, Zhang, Yilu, Xu, Li, Xie, Zhuo, Yu, Junke, Zheng   +5 more
openaire   +2 more sources

The P2X7 Receptor-Interleukin-1 Liaison [PDF]

Frontiers in Pharmacology, 2017
Interleukin-1β (IL-1β) plays a central role in stimulation of innate immune system and inflammation and in several chronic inflammatory diseases. These include rare hereditary conditions, e.g., auto-inflammatory syndromes, as well as common pathologies, such as type II diabetes, gout and atherosclerosis.
GIULIANI, Anna Lisa, SARTI, Alba Clara, FALZONI, Simonetta, DI VIRGILIO, Francesco   +3 more
openaire   +3 more sources

Dissecting activation steps in P2X7 receptors

Biochemical and Biophysical Research Communications, 2021
P2X7 receptors are trimeric ion channels activated by extracellular ATP. Upon activation, they trigger cytolysis and apoptosis but also control cell proliferation. To shed more light on channel gating and the underlying function of the individual subunits, receptors of concatenated subunits were built containing a defined number of functional binding ...
Milica Gusic, Klaus Benndorf, Christian Sattler   +2 more
openaire   +2 more sources

P2X7 in Cancer: From Molecular Mechanisms to Therapeutics

Frontiers in Pharmacology, 2020
P2X7 is a transmembrane receptor expressed in multiple cell types including neurons, dendritic cells, macrophages, monocytes, B and T cells where it can drive a wide range of physiological responses from pain transduction to immune response.
Romain Lara, Elena Adinolfi, Catherine A. Harwood, Mike Philpott, Julian A. Barden, Francesco Di Virgilio, Shaun McNulty   +6 more
doaj   +1 more source

Pregnant Women and Endocrine Disruptors: Role of P2X7 Receptor and Mitochondrial Alterations in Placental Cell Disorders

Cells, 2022
In pregnant women, the lungs, skin and placenta are exposed daily to endocrine-disrupting chemicals (EDCs). EDCs induce multiple adverse effects, not only on endocrine organs, but also on non-endocrine organs, with the P2X7 cell death receptor being ...
Sophie Fouyet, Elodie Olivier, Pascale Leproux, Mélody Dutot, Patrice Rat   +4 more
doaj   +1 more source