Results 31 to 40 of about 12,681 (186)
Journal of Osteoporosis, 2012 P2X7 receptor-mediated purinergic signaling is a well-known mechanism involved in bone remodeling. The P2X7 receptor has been implicated in the pathophysiology of various bone and cartilage diseases, including rheumatoid arthritis (RA), a widespread and ...
Alberto Baroja-Mazo, Pablo Pelegrín
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Journal of Neuroinflammation, 2021 Background The identification of endogenous signals that lead to microglial activation is a key step in understanding neuroinflammatory cascades. As ATP release accompanies mechanical strain to neural tissue, and as the P2X7 receptor for ATP is expressed
Keith E. Campagno +9 more
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Dissecting activation steps in P2X7 receptors
Biochemical and Biophysical Research Communications, 2021 P2X7 receptors are trimeric ion channels activated by extracellular ATP. Upon activation, they trigger cytolysis and apoptosis but also control cell proliferation. To shed more light on channel gating and the underlying function of the individual subunits, receptors of concatenated subunits were built containing a defined number of functional binding ...
Milica Gusic +2 more
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Mammalian P2X7 receptor pharmacology: comparison of recombinant mouse, rat and human P2X7 receptors [PDF]
British Journal of Pharmacology, 2009 Background and purpose: Acute activation of P2X7 receptors rapidly opens a non‐selective cation channel. Sustained P2X7 receptor activation leads to the formation of cytolytic pores, mediated by downstream recruitment of hemichannels to the cell surface.
Diana L, Donnelly-Roberts +3 more
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PLoS Pathogens, 2017 A complete understanding of the mechanisms underlying the acquisition of protective immunity is crucial to improve vaccine strategies to eradicate malaria.
Érika Machado de Salles +13 more
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The C-terminus of human nucleotide receptor P2X7 is critical for receptor oligomerization and N-linked glycosylation. [PDF]
PLoS ONE, 2013 The P2X7 receptor binds extracellular ATP to mediate numerous inflammatory responses and is considered a potential biomarker and therapeutic target for diverse inflammatory and neurological diseases.
Lisa E Wickert +6 more
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Frontiers in Cellular Neuroscience, 2021 Purinergic receptors play important roles in central nervous system (CNS), where the bulk of these receptors are implicated in neuroinflammatory responses and regulation of cellular function of neurons, microglial and astrocytes.
Paul R. Territo +2 more
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P2X7 receptor activation leads to NLRP3-independent IL-1β release by human macrophages
Cell Communication and Signaling, 2023 Background The purinergic receptor P2X7 plays a crucial role in infection, inflammation, and cell death. It is thought that P2X7 receptor stimulation triggers processing and release of the pro-inflammatory cytokine interleukin (IL)-1β by activation of ...
Judith Bockstiegel +2 more
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Frontiers in Pharmacology, 2023 Introduction: Sepsis is defined as a multifactorial debilitating condition with high risks of death. The intense inflammatory response causes deleterious effects on the brain, a condition called sepsis-associated encephalopathy.
Vinícius Santos Alves +17 more
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British Journal of Clinical Pharmacology, EarlyView.Chronic pain represents a complex debilitating condition that extends beyond the protective function of physiological pain, often persisting as an independent disease entity. Chronic primary and secondary pain syndromes reflect a multifaceted continuum involving nociceptive, neuropathic and nociplastic mechanisms.
Stefania Nobili +6 more
wiley +1 more source